84. Bartha B, Huber C, Schröder P (2014) Uptake and metabolism of diclofenac in Typha
latifolia – how plants cope with human pharmaceutical pollution. Plant Sci 227:12–20.
https://doi.org/10.1016/j.plantsci.2014.06.001
85. Chen F, Huber C, Schröder P (2017) Fate of the sunscreen compound oxybenzone in Cyperus
alternifolius based hydroponic culture: uptake, biotransformation and phytotoxicity.
Chemosphere 182:638–646. https://doi.org/10.1016/j.chemosphere.2017.05.072
86. Huber C, Bartha B, Schröder P (2012) Metabolism of diclofenac in plants – hydroxylation is
followed by glucose conjugation. J Hazard Mater 243:250–256. https://doi.org/10.1016/j.
jhazmat.2012.10.023
87. Lamoureux GL, Rusness DG (1995) Quinclorac absorption, translocation, metabolism, and
toxicity in leafy spurge (Euphorbia esula). Pestic Biochem Physiol 53:210–226. https://doi.
org/10.1006/pest.1995.1069
88. Schröder P, Matucha M, Forczek ST, Uhlířová H, Fuksová K, Albrechtová J (2003) Uptake,
translocation and fate of trichloroacetic acid in a Norway spruce/soil system. Chemosphere
52:437–442. https://doi.org/10.1016/S0045-6535(03)00208-X
89. Macherius A, Seiwert B, Schröder P, Huber C, Lorenz W, Reemtsma T (2014) Identification
of plant metabolites of environmental contaminants by UPLC-QToF-MS: the in vitro metabolism of triclosan in horseradish. J Agric Food Chem 62:1001–1009. https://doi.org/10.1021/
jf404784q
90. Coleman M (2007) Spatial and temporal patterns of root distribution in developing stands of
four woody crop species grown with drip irrigation and fertilization. Plant and Soil
299:195–213. https://doi.org/10.1007/s11104-007-9375-5
91. Ishikawa T, Wright CD, Ishizuka H (1994) GS-X pump is functionally overexpressed in
cis-diamminedichloroplatinum (II)-resistant human leukemia HL-60 cells and down-regulated
by cell differentiation. J Biol Environ Sci 269:29085–29093
92. Lamoureux GL, Rusness DG, Schröder P, Rennenberg H (1991) Diphenyl ether herbicide
metabolism in a spruce cell suspension culture: the identification of two novel metabolites
derived from a glutathione conjugate. Pestic Biochem Physiol 39:291–301. https://doi.org/10.
1016/0048-3575(91)90124-5
93. Schröder P, Navarro-Aviñó J, Azaizeh H, Goldhirsh AG, DiGregorio S, Komives T,
Langergraber G, Lenz A, Maestri E, Memon AR, Ranalli A, Sebastiani L, Smrcek S,
Vanek T, Vuilleumier S, Wissing F (2007) Using phytoremediation technologies to upgrade
waste water treatment in Europe. Environ Sci Pollut Res 14:490–497
94. Brazier-Hicks M, Evans KM, Cunningham OD, Hodgson DRW, Steel PG, Edwards R (2008)
Catabolism of glutathione conjugates in Arabidopsis thaliana: role in metabolic reactivation of
the herbicide safener fenclorim. J Biol Chem 283:21102–21112. https://doi.org/10.1074/jbc.
M801998200
95. Wolf AE, Dietz KJ, Schröder P (1996) A carboxypeptidase degrades glutathione conjugates in
the vacuoles of higher plants. FEBS Lett 384:31–34
96. Martinoia E, Meyer S, De Angeli A, Nagy R (2012) Vacuolar transporters in their physiological context. Annu Rev Plant Biol 63:183–213. https://doi.org/10.1146/annurev-arplant042811-105608
97. Chen F, Schnick S, Schröder P (2018) Concentration effects of the UV filter oxybenzone in
Cyperus alternifolius: assessment of tolerance by stress-related response. Environ Sci Pollut
Res 25:16080–16090. https://doi.org/10.1007/s11356-018-1839-z
98. Rea PA (2007) Plant ATP-binding cassette transporters. Annu Rev Plant Biol 58:347–375.
https://doi.org/10.1146/annurev.arplant.57.032905.105406
99. Sandermann H, Schmitt R, Eckey H, Bauknecht T (1991) Plant biochemistry of xenobiotics:
isolation and properties of soybean O- and N-glucosyl and O- and N-malonyltransferases for
chlorinated phenols and anilines. Arch Biochem Biophys 287:341–350. https://doi.org/10.
1016/0003-9861(91)90488-5
100. Taguchi G, Ubukata T, Nozue H, Kobayashi Y, Takahi M, Yamamoto H, Hayashida N (2010)
Malonylation is a key reaction in the metabolism of xenobiotic phenolic glucosides in
Uptake and Translocation of Pharmaceuticals in Plants:. . .
137
latifolia – how plants cope with human pharmaceutical pollution. Plant Sci 227:12–20.
https://doi.org/10.1016/j.plantsci.2014.06.001
85. Chen F, Huber C, Schröder P (2017) Fate of the sunscreen compound oxybenzone in Cyperus
alternifolius based hydroponic culture: uptake, biotransformation and phytotoxicity.
Chemosphere 182:638–646. https://doi.org/10.1016/j.chemosphere.2017.05.072
86. Huber C, Bartha B, Schröder P (2012) Metabolism of diclofenac in plants – hydroxylation is
followed by glucose conjugation. J Hazard Mater 243:250–256. https://doi.org/10.1016/j.
jhazmat.2012.10.023
87. Lamoureux GL, Rusness DG (1995) Quinclorac absorption, translocation, metabolism, and
toxicity in leafy spurge (Euphorbia esula). Pestic Biochem Physiol 53:210–226. https://doi.
org/10.1006/pest.1995.1069
88. Schröder P, Matucha M, Forczek ST, Uhlířová H, Fuksová K, Albrechtová J (2003) Uptake,
translocation and fate of trichloroacetic acid in a Norway spruce/soil system. Chemosphere
52:437–442. https://doi.org/10.1016/S0045-6535(03)00208-X
89. Macherius A, Seiwert B, Schröder P, Huber C, Lorenz W, Reemtsma T (2014) Identification
of plant metabolites of environmental contaminants by UPLC-QToF-MS: the in vitro metabolism of triclosan in horseradish. J Agric Food Chem 62:1001–1009. https://doi.org/10.1021/
jf404784q
90. Coleman M (2007) Spatial and temporal patterns of root distribution in developing stands of
four woody crop species grown with drip irrigation and fertilization. Plant and Soil
299:195–213. https://doi.org/10.1007/s11104-007-9375-5
91. Ishikawa T, Wright CD, Ishizuka H (1994) GS-X pump is functionally overexpressed in
cis-diamminedichloroplatinum (II)-resistant human leukemia HL-60 cells and down-regulated
by cell differentiation. J Biol Environ Sci 269:29085–29093
92. Lamoureux GL, Rusness DG, Schröder P, Rennenberg H (1991) Diphenyl ether herbicide
metabolism in a spruce cell suspension culture: the identification of two novel metabolites
derived from a glutathione conjugate. Pestic Biochem Physiol 39:291–301. https://doi.org/10.
1016/0048-3575(91)90124-5
93. Schröder P, Navarro-Aviñó J, Azaizeh H, Goldhirsh AG, DiGregorio S, Komives T,
Langergraber G, Lenz A, Maestri E, Memon AR, Ranalli A, Sebastiani L, Smrcek S,
Vanek T, Vuilleumier S, Wissing F (2007) Using phytoremediation technologies to upgrade
waste water treatment in Europe. Environ Sci Pollut Res 14:490–497
94. Brazier-Hicks M, Evans KM, Cunningham OD, Hodgson DRW, Steel PG, Edwards R (2008)
Catabolism of glutathione conjugates in Arabidopsis thaliana: role in metabolic reactivation of
the herbicide safener fenclorim. J Biol Chem 283:21102–21112. https://doi.org/10.1074/jbc.
M801998200
95. Wolf AE, Dietz KJ, Schröder P (1996) A carboxypeptidase degrades glutathione conjugates in
the vacuoles of higher plants. FEBS Lett 384:31–34
96. Martinoia E, Meyer S, De Angeli A, Nagy R (2012) Vacuolar transporters in their physiological context. Annu Rev Plant Biol 63:183–213. https://doi.org/10.1146/annurev-arplant042811-105608
97. Chen F, Schnick S, Schröder P (2018) Concentration effects of the UV filter oxybenzone in
Cyperus alternifolius: assessment of tolerance by stress-related response. Environ Sci Pollut
Res 25:16080–16090. https://doi.org/10.1007/s11356-018-1839-z
98. Rea PA (2007) Plant ATP-binding cassette transporters. Annu Rev Plant Biol 58:347–375.
https://doi.org/10.1146/annurev.arplant.57.032905.105406
99. Sandermann H, Schmitt R, Eckey H, Bauknecht T (1991) Plant biochemistry of xenobiotics:
isolation and properties of soybean O- and N-glucosyl and O- and N-malonyltransferases for
chlorinated phenols and anilines. Arch Biochem Biophys 287:341–350. https://doi.org/10.
1016/0003-9861(91)90488-5
100. Taguchi G, Ubukata T, Nozue H, Kobayashi Y, Takahi M, Yamamoto H, Hayashida N (2010)
Malonylation is a key reaction in the metabolism of xenobiotic phenolic glucosides in
Uptake and Translocation of Pharmaceuticals in Plants:. . .
137