134
L. Schorr et al.
78. Philippot, L.: Denitrifying genes in bacterial and Archaeal genomes. Biochim. Biophys. Acta
(BBA) 1577, 355–376 (2002). https://doi.org/10.1016/S0167-4781(02)00420-7
79. Pochana, K.: Study of factors affecting simultaneous nitrification and denitrification (SND).
Water Sci. Technol. 39, 61–68 (1999). https://doi.org/10.1016/S0273-1223(99)00123-7
80. Pomeranz, A., Korzets, Z., Vanunu, D., Krystal, H., Wolach, B.: Elevated salt and nitrate
levels in drinking water cause an increase of blood pressure in schoolchildren. Kidney Blood
Press. Res. 23, 400–403 (2000). https://doi.org/10.1159/000025989
81. Prosser, J.I.: Nitrogen in soils. In: Nitrification Encyclopedia of Soils in the Environment,
pp. 31–39 (2005). https://doi.org/10.1016/B0-12-348530-4/00512-9
82. Qureshi, N., Annous, B.A., Ezeji, T.C., Karcher, P., Maddox, I.S.: Biofilm reactors for industrial bioconversion processes: employing potential of enhanced reaction rates. Microb. Cell
Fact. 4, 24 (2005). https://doi.org/10.1186/1475-2859-4-24
83. Rádiková, Z., Tajtakova, M., KoCan, A., Trnovec, T., Sebokova, E., Klimes, I., Langer, P.:
Possible effects of environmental nitrates and toxic organochlorines on human thyroid in
highly polluted areas in Slovakia. Thyroid 18, 353–362 (2008). https://doi.org/10.1089/thy.
2007.0182
84. Rogers, C., Oldroyd, G.E.D.: Synthetic biology approaches to engineering the nitrogen
symbiosis in cereals. J Exp. Bot. 65, 1939–1946 (2014). https://doi.org/10.1093/jxb/eru098
85. Santos-Merino, M., Singh, A.K., Ducat, D.C.: New applications of synthetic biology tools
for cyanobacterial metabolic engineering. Front. Bioeng. Biotechnol. (2019). https://doi.org/
10.3389/fbioe.2019.00033
86. Satoh, H., Nakamura, Y., Ono, H., Okabe, S.: Effect of oxygen concentration on nitrification
and denitrification in single activated sludge flocs. Biotechnol. Bioeng. 83, 604–607 (2003).
https://doi.org/10.1002/bit.10717
87. Schlesinger, W.H.: On the fate of anthropogenic nitrogen. PNAS 106, 203–208 (2009). https://
doi.org/10.1073/pnas.0810193105
88. Schmidt, I., Sliekers, O., Schmid, M., Cirpus, I., Strous, M., Bock, E., et al.: Aerobic and
anaerobic ammonia oxidizing bacteria-competitors or natural partners? FEMS Microbiol.
Ecol. 39, 175–181 (2002). https://doi.org/10.1111/j.1574-6941.2002.tb00920.x
89. Schullehner, J., Hansen, B., Thygesen, M., Pedersen, C.B., Sigsgaard, T.: Nitrate in drinking
water and colorectal cancer risk: a nationwide population-based cohort study. Int. J. Cancer
143, 73–79 (2018). https://doi.org/10.1002/ijc.31306
90. Schwientek, M., Einsiedl, F., Stichler, W., Stögbauer, A., Strauss, H., Maloszewski, P.:
Evidence for denitrification regulated by pyrite oxidation in a heterogeneous porous groundwater system. Chem. Geol. 255, 60–67 (2008). https://doi.org/10.1016/j.chemgeo.2008.
06.005
91. Shao, Y., Lu, N., Wu, Z., Cai, C., Wan, S., Zhang, L.L., Zhou, F., Xiao, S., Liu, L., Zeng, X.,
Zheng, H., Yang, C., Zhao, Z., Zhao, G., Zhou, J.Q., Xue, X., Qin, Z.: Creating a functional
single-chromosome yeast. Nature 560, 331–335 (2018). https://doi.org/10.1038/s41586-0180382x
92. Sparacino-Watkins, C., Stolz, J.F., Basu, P.: Nitrate and periplasmic nitrate reductases. Chem.
Soc. Rev. 43, 676–706 (2014). https://doi.org/10.1039/c3cs60249d
93. Stewart, V., Parales, J.: Identification and expression of genes narL and narX of the nar (nitrate
reductase) locus in Escherichia coli K-12. J. Bacteriol. 170, 1589–1597 (1988). https://doi.
org/10.1128/jb.170.4.1589-1597.1988
94. Strous, M., van Gerven, E., Zheng, P., Kuenen, J.G., Jetten, M.S.M.: Ammonium removal from
concentrated waste streams with the anaerobic ammonium oxidation (Anammox) process in
different reactor configurations. Water Res. 31, 1955–1962 (1997). https://doi.org/10.1016/
S0043-1354(97)00055-9
95. Suto, R., Ishimoto, C., Chikyu, M., Aihara, Y., Matsumoto, T., Uenishi, H., et al.: Anammox
biofilm in activated sludge swine wastewater treatment plants. Chemosphere 167, 300–307
(2017). https://doi.org/10.1016/j.chemosphere.2016.09.121
96. Tajtáková, M., Semanová, Z., Tomková, Z., Szökeová, E., Majoroš, J., Rádiková, Ž., et al.:
Increased thyroid volume and frequency of thyroid disorders signs in school children from
L. Schorr et al.
78. Philippot, L.: Denitrifying genes in bacterial and Archaeal genomes. Biochim. Biophys. Acta
(BBA) 1577, 355–376 (2002). https://doi.org/10.1016/S0167-4781(02)00420-7
79. Pochana, K.: Study of factors affecting simultaneous nitrification and denitrification (SND).
Water Sci. Technol. 39, 61–68 (1999). https://doi.org/10.1016/S0273-1223(99)00123-7
80. Pomeranz, A., Korzets, Z., Vanunu, D., Krystal, H., Wolach, B.: Elevated salt and nitrate
levels in drinking water cause an increase of blood pressure in schoolchildren. Kidney Blood
Press. Res. 23, 400–403 (2000). https://doi.org/10.1159/000025989
81. Prosser, J.I.: Nitrogen in soils. In: Nitrification Encyclopedia of Soils in the Environment,
pp. 31–39 (2005). https://doi.org/10.1016/B0-12-348530-4/00512-9
82. Qureshi, N., Annous, B.A., Ezeji, T.C., Karcher, P., Maddox, I.S.: Biofilm reactors for industrial bioconversion processes: employing potential of enhanced reaction rates. Microb. Cell
Fact. 4, 24 (2005). https://doi.org/10.1186/1475-2859-4-24
83. Rádiková, Z., Tajtakova, M., KoCan, A., Trnovec, T., Sebokova, E., Klimes, I., Langer, P.:
Possible effects of environmental nitrates and toxic organochlorines on human thyroid in
highly polluted areas in Slovakia. Thyroid 18, 353–362 (2008). https://doi.org/10.1089/thy.
2007.0182
84. Rogers, C., Oldroyd, G.E.D.: Synthetic biology approaches to engineering the nitrogen
symbiosis in cereals. J Exp. Bot. 65, 1939–1946 (2014). https://doi.org/10.1093/jxb/eru098
85. Santos-Merino, M., Singh, A.K., Ducat, D.C.: New applications of synthetic biology tools
for cyanobacterial metabolic engineering. Front. Bioeng. Biotechnol. (2019). https://doi.org/
10.3389/fbioe.2019.00033
86. Satoh, H., Nakamura, Y., Ono, H., Okabe, S.: Effect of oxygen concentration on nitrification
and denitrification in single activated sludge flocs. Biotechnol. Bioeng. 83, 604–607 (2003).
https://doi.org/10.1002/bit.10717
87. Schlesinger, W.H.: On the fate of anthropogenic nitrogen. PNAS 106, 203–208 (2009). https://
doi.org/10.1073/pnas.0810193105
88. Schmidt, I., Sliekers, O., Schmid, M., Cirpus, I., Strous, M., Bock, E., et al.: Aerobic and
anaerobic ammonia oxidizing bacteria-competitors or natural partners? FEMS Microbiol.
Ecol. 39, 175–181 (2002). https://doi.org/10.1111/j.1574-6941.2002.tb00920.x
89. Schullehner, J., Hansen, B., Thygesen, M., Pedersen, C.B., Sigsgaard, T.: Nitrate in drinking
water and colorectal cancer risk: a nationwide population-based cohort study. Int. J. Cancer
143, 73–79 (2018). https://doi.org/10.1002/ijc.31306
90. Schwientek, M., Einsiedl, F., Stichler, W., Stögbauer, A., Strauss, H., Maloszewski, P.:
Evidence for denitrification regulated by pyrite oxidation in a heterogeneous porous groundwater system. Chem. Geol. 255, 60–67 (2008). https://doi.org/10.1016/j.chemgeo.2008.
06.005
91. Shao, Y., Lu, N., Wu, Z., Cai, C., Wan, S., Zhang, L.L., Zhou, F., Xiao, S., Liu, L., Zeng, X.,
Zheng, H., Yang, C., Zhao, Z., Zhao, G., Zhou, J.Q., Xue, X., Qin, Z.: Creating a functional
single-chromosome yeast. Nature 560, 331–335 (2018). https://doi.org/10.1038/s41586-0180382x
92. Sparacino-Watkins, C., Stolz, J.F., Basu, P.: Nitrate and periplasmic nitrate reductases. Chem.
Soc. Rev. 43, 676–706 (2014). https://doi.org/10.1039/c3cs60249d
93. Stewart, V., Parales, J.: Identification and expression of genes narL and narX of the nar (nitrate
reductase) locus in Escherichia coli K-12. J. Bacteriol. 170, 1589–1597 (1988). https://doi.
org/10.1128/jb.170.4.1589-1597.1988
94. Strous, M., van Gerven, E., Zheng, P., Kuenen, J.G., Jetten, M.S.M.: Ammonium removal from
concentrated waste streams with the anaerobic ammonium oxidation (Anammox) process in
different reactor configurations. Water Res. 31, 1955–1962 (1997). https://doi.org/10.1016/
S0043-1354(97)00055-9
95. Suto, R., Ishimoto, C., Chikyu, M., Aihara, Y., Matsumoto, T., Uenishi, H., et al.: Anammox
biofilm in activated sludge swine wastewater treatment plants. Chemosphere 167, 300–307
(2017). https://doi.org/10.1016/j.chemosphere.2016.09.121
96. Tajtáková, M., Semanová, Z., Tomková, Z., Szökeová, E., Majoroš, J., Rádiková, Ž., et al.:
Increased thyroid volume and frequency of thyroid disorders signs in school children from