However, thus far, no efforts were made to give a comprehensive survey on the
state of the art of enantioselective trace analysis and to reflect the future of this
promising new field of analytical research. This monograph intends to fill this
obvious gap and aims at delivering a comprehensive tool for the information of
experienced trace analysts as well as of interested students and non-chemists.
The international research on chirality of xenobiotics today mainly focuses on the
following two principal questions:
Why does chirality play such an outstanding role when biochemical transformation
and accumulation processes of chiral organic pollutants in organisms, from
bacteria up to human beings, are being discussed?
How can chirality as a basic selector for enzymatic processes be documented and
proven for organic chemicals, which are degraded and/or accumulated in ultratrace concentrations.
These two questions will form the common thread throughout the present survey.
We will mainly focus on the trace analytical and ecotoxicological aspects of
molecular asymmetry. Since almost the entire research work is centrally related to
chiral organic xenobiotics, we will largely confine ourselves to organic compounds,
although in general parts of this book theoretical aspects of chiral inorganic substances will also be mentioned.
Hamburg
Heinrich Hühnerfuss
Tromsø
Roland Kallenborn
October 2000
References
1. Pasteur L (1848) Memoire sur la relation qui peut exister entre la forme crystalline et la
composition chimique, et sur la cause de la polarisation rotatoire. C R Acad Sci 26:535–538
2. Jacques J (1993) The molecule and its double. McGraw-Hill, p 128
3. Gardner M (1990) The ambidextrous universe: mirror asymmetry and time-reversed worlds.
Scribner, New York, p 293
4. Faller J, Hühnerfuss H, König WA, Krebber R, Ludwig P (1991) Do marine bacteria degrade
alpha-hexachlorocyclohexane stereoselectively? Environ Sci Technol 25:676–678
5. Kallenborn R, Hühnerfuss H, König WA (1991) Enantioselective metabolism of (Æ)-alphahexachlorocyclohexane in organs of the Eider Duck. Angew Chern 103:328–329; Angew Chern
Int Ed Engl 130:320–321
x
Preface (1st Edition)
state of the art of enantioselective trace analysis and to reflect the future of this
promising new field of analytical research. This monograph intends to fill this
obvious gap and aims at delivering a comprehensive tool for the information of
experienced trace analysts as well as of interested students and non-chemists.
The international research on chirality of xenobiotics today mainly focuses on the
following two principal questions:
Why does chirality play such an outstanding role when biochemical transformation
and accumulation processes of chiral organic pollutants in organisms, from
bacteria up to human beings, are being discussed?
How can chirality as a basic selector for enzymatic processes be documented and
proven for organic chemicals, which are degraded and/or accumulated in ultratrace concentrations.
These two questions will form the common thread throughout the present survey.
We will mainly focus on the trace analytical and ecotoxicological aspects of
molecular asymmetry. Since almost the entire research work is centrally related to
chiral organic xenobiotics, we will largely confine ourselves to organic compounds,
although in general parts of this book theoretical aspects of chiral inorganic substances will also be mentioned.
Hamburg
Heinrich Hühnerfuss
Tromsø
Roland Kallenborn
October 2000
References
1. Pasteur L (1848) Memoire sur la relation qui peut exister entre la forme crystalline et la
composition chimique, et sur la cause de la polarisation rotatoire. C R Acad Sci 26:535–538
2. Jacques J (1993) The molecule and its double. McGraw-Hill, p 128
3. Gardner M (1990) The ambidextrous universe: mirror asymmetry and time-reversed worlds.
Scribner, New York, p 293
4. Faller J, Hühnerfuss H, König WA, Krebber R, Ludwig P (1991) Do marine bacteria degrade
alpha-hexachlorocyclohexane stereoselectively? Environ Sci Technol 25:676–678
5. Kallenborn R, Hühnerfuss H, König WA (1991) Enantioselective metabolism of (Æ)-alphahexachlorocyclohexane in organs of the Eider Duck. Angew Chern 103:328–329; Angew Chern
Int Ed Engl 130:320–321
x
Preface (1st Edition)