LaPlante SR, Edwards PJ, Fader LD, Jakalian A, Hucke O (2011) Revealing atropisomer axial
chirality in drug discovery. ChemMedChem 6(3):505–513
Lehmler HJ, Harrad SJ, Hühnerfuss H, Kania-Korwel I, Lee CM, Lu Z, Wong CS (2010) Chiral
polychlorinated biphenyl transport, metabolism, and distribution: a review. Environ Sci Technol
44(8):2757–2766
Levitt DG (2010) Quantitative relationship between the octanol/water partition coefficient and the
diffusion limitation of the exchange between adipose and blood. BMC Clin Pharmacol 10:1
Li L, Zhou S, Jin L, Zhang C, Liu W (2010) Enantiomeric separation of organophosphorus
pesticides by high-performance liquid chromatography, gas chromatography and capillary
electrophoresis and their applications to environmental fate and toxicity assays. J Chromatogr
B Analyt Technol Biomed Life Sci 878(17–18):1264–1276
Li X, Parkin SR, Lehmler HJ (2018) Absolute configuration of 2,2
0 ,3,3
0 ,6-pentachlorinatedbiphenyl
(PCB 84) atropisomers. Environ Sci Pollut Res Int 25(17):16402–16410
Li G, DeLaney K, Li L (2019) Molecular basis for chirality-regulated Abeta self-assembly and
receptor recognition revealed by ion mobility-mass spectrometry. Nat Commun 10(1):5038
Lin G-Q, You Q-D, Cheng J-F (2011) Chiral drugs: chemistry and biological action. Wiley,
Hoboken, NJ
Liu D, Zou X, Gao M, Gu M, Xiao H (2014) Hydrophilic organic/salt-containing aqueous
two-phase solvent system for counter-current chromatography: a novel technique for separation
of polar compounds. J Chromatogr A 1356:157–162
Lu Z, Kania-Korwel I, Lehmler HJ, Wong CS (2013) Stereoselective formation of mono- and
dihydroxylated polychlorinated biphenyls by rat cytochrome P450 2B1. Environ Sci Technol 47
(21):12184–12192
McCalley DV (2017) Understanding and manipulating the separation in hydrophilic interaction
liquid chromatography. J Chromatogr A 1523:49–71
Nachtigall FM, Rojas M, Santos LS (2018) MALDI coupled to modified traveling-wave
ion-mobility mass spectrometry for fast enantiomeric determination. J Mass Spectrom 53
(8):693–699
Naile JE, Garrison AW, Avants JK, Washington JW (2016) Isomers/enantiomers of
perfluorocarboxylic acids: method development and detection in environmental samples.
Chemosphere 144:1722–1728
Nillos MG, Gan J, Schlenk D (2010) Chirality of organophosphorus pesticides: analysis and
toxicity. J Chromatogr B Analyt Technol Biomed Life Sci 878(17–18):1277–1284
Peluso P, Mamane V, Aubert E, Cossu S (2017) Recent trends and applications in liquid-phase
chromatography enantioseparation of atropisomers. Electrophoresis 38(15):1830–1850
Perez-Fernandez V, Castro-Puyana M, Gonzalez MJ, Marina ML, Garcia MA, Gomara B (2012)
Simultaneous enantioselective separation of polychlorinated biphenyls and their methyl sulfone
metabolites by heart-cut MDGC: determination of enantiomeric fractions in fish oils and cow
liver samples. Chirality 24(7):577–583
Qi P, Yuan Y, Wang Z, Wang X, Xu H, Zhang H, Wang Q, Wang X (2016) Use of liquid
chromatography- quadrupole time-of-flight mass spectrometry for enantioselective separation
and determination of pyrisoxazole in vegetables, strawberry and soil. J Chromatogr A
1449:62–70
Rayne S, Forest K (2010) Dow and Kaw, eff vs. Kow and Kaw degrees: acid/base ionization effects
on partitioning properties and screening commercial chemicals for long-range transport and
bioaccumulation potential. J Environ Sci Health A Tox Hazard Subst Environ Eng 45
(12):1550–1594
Reddy IK, Miḥvar RA (2004) Chirality in drug design and development. Marcel Dekker, New York
Roman IP, Mastromichali A, Tyrovola K, Canals A, Psillakis E (2014) Rapid determination of
octanol-water partition coefficient using vortex-assisted liquid-liquid microextraction. J
Chromatogr A 1330:1–5
Salieres P, Maquet A, Haessler S, Caillat J, Taieb R (2012) Imaging orbitals with attosecond and
angstrom resolutions: toward attochemistry? Rep Prog Phys 75(6):062401
26
2 Criteria for the Selection of a Proper Enantiomer-Selective Analytical Method
chirality in drug discovery. ChemMedChem 6(3):505–513
Lehmler HJ, Harrad SJ, Hühnerfuss H, Kania-Korwel I, Lee CM, Lu Z, Wong CS (2010) Chiral
polychlorinated biphenyl transport, metabolism, and distribution: a review. Environ Sci Technol
44(8):2757–2766
Levitt DG (2010) Quantitative relationship between the octanol/water partition coefficient and the
diffusion limitation of the exchange between adipose and blood. BMC Clin Pharmacol 10:1
Li L, Zhou S, Jin L, Zhang C, Liu W (2010) Enantiomeric separation of organophosphorus
pesticides by high-performance liquid chromatography, gas chromatography and capillary
electrophoresis and their applications to environmental fate and toxicity assays. J Chromatogr
B Analyt Technol Biomed Life Sci 878(17–18):1264–1276
Li X, Parkin SR, Lehmler HJ (2018) Absolute configuration of 2,2
0 ,3,3
0 ,6-pentachlorinatedbiphenyl
(PCB 84) atropisomers. Environ Sci Pollut Res Int 25(17):16402–16410
Li G, DeLaney K, Li L (2019) Molecular basis for chirality-regulated Abeta self-assembly and
receptor recognition revealed by ion mobility-mass spectrometry. Nat Commun 10(1):5038
Lin G-Q, You Q-D, Cheng J-F (2011) Chiral drugs: chemistry and biological action. Wiley,
Hoboken, NJ
Liu D, Zou X, Gao M, Gu M, Xiao H (2014) Hydrophilic organic/salt-containing aqueous
two-phase solvent system for counter-current chromatography: a novel technique for separation
of polar compounds. J Chromatogr A 1356:157–162
Lu Z, Kania-Korwel I, Lehmler HJ, Wong CS (2013) Stereoselective formation of mono- and
dihydroxylated polychlorinated biphenyls by rat cytochrome P450 2B1. Environ Sci Technol 47
(21):12184–12192
McCalley DV (2017) Understanding and manipulating the separation in hydrophilic interaction
liquid chromatography. J Chromatogr A 1523:49–71
Nachtigall FM, Rojas M, Santos LS (2018) MALDI coupled to modified traveling-wave
ion-mobility mass spectrometry for fast enantiomeric determination. J Mass Spectrom 53
(8):693–699
Naile JE, Garrison AW, Avants JK, Washington JW (2016) Isomers/enantiomers of
perfluorocarboxylic acids: method development and detection in environmental samples.
Chemosphere 144:1722–1728
Nillos MG, Gan J, Schlenk D (2010) Chirality of organophosphorus pesticides: analysis and
toxicity. J Chromatogr B Analyt Technol Biomed Life Sci 878(17–18):1277–1284
Peluso P, Mamane V, Aubert E, Cossu S (2017) Recent trends and applications in liquid-phase
chromatography enantioseparation of atropisomers. Electrophoresis 38(15):1830–1850
Perez-Fernandez V, Castro-Puyana M, Gonzalez MJ, Marina ML, Garcia MA, Gomara B (2012)
Simultaneous enantioselective separation of polychlorinated biphenyls and their methyl sulfone
metabolites by heart-cut MDGC: determination of enantiomeric fractions in fish oils and cow
liver samples. Chirality 24(7):577–583
Qi P, Yuan Y, Wang Z, Wang X, Xu H, Zhang H, Wang Q, Wang X (2016) Use of liquid
chromatography- quadrupole time-of-flight mass spectrometry for enantioselective separation
and determination of pyrisoxazole in vegetables, strawberry and soil. J Chromatogr A
1449:62–70
Rayne S, Forest K (2010) Dow and Kaw, eff vs. Kow and Kaw degrees: acid/base ionization effects
on partitioning properties and screening commercial chemicals for long-range transport and
bioaccumulation potential. J Environ Sci Health A Tox Hazard Subst Environ Eng 45
(12):1550–1594
Reddy IK, Miḥvar RA (2004) Chirality in drug design and development. Marcel Dekker, New York
Roman IP, Mastromichali A, Tyrovola K, Canals A, Psillakis E (2014) Rapid determination of
octanol-water partition coefficient using vortex-assisted liquid-liquid microextraction. J
Chromatogr A 1330:1–5
Salieres P, Maquet A, Haessler S, Caillat J, Taieb R (2012) Imaging orbitals with attosecond and
angstrom resolutions: toward attochemistry? Rep Prog Phys 75(6):062401
26
2 Criteria for the Selection of a Proper Enantiomer-Selective Analytical Method