489
© The Editor(s) (if applicable) and The Author(s), under exclusive license
to Springer Nature Switzerland AG 2021
M. S. H. Akash et al. (eds.), Endocrine Disrupting Chemicals-induced
Metabolic Disorders and Treatment Strategies, Emerging Contaminants
and Associated Treatment Technologies,
https://doi.org/10.1007/978-3-030-45923-9_28
Chapter 28
Bioactive Compounds for the Treatment
of Metabolic Disorders
Tauqeer Hussain Mallhi, Maria Rasheed, Yusra Habib Khan,
Abdulaziz Ibrahim Alzarea, and Ahsan Aftab Raja
Abstract The exposure of endocrine disrupting chemicals results in disruption of
normal energy homeostasis control. Decrease metabolism of carbohydrates, proteins
and fats occur due to EDCs induced thyroid dysfunction. The obesogenic and metabolic dysregulation ability leads to development of metabolic disorders. Plasticizers
(bisphenol A), persistent organic pollutants (dioxins), organotins (tributyltin), and
organochlorines (dichlorodiphenyltrichloroethane) are examples of some EDCs.
There has been an increasing focus to investigate association between human exposure to EDCs and disease over the past few decades. Bioactive compounds are found
to be effective in these EDCs induced metabolic disorders including diabetes mellitus,
hypertension, obesity, hyperlipidemia, and non-alcoholic fatty liver disease. These
compounds obtained from fruits, vegetables, and whole grains exert pharmacological
effects in humans and play important role in defense and signaling. The use of these
compounds is advantageous due to easy availability, safety, and few side effects. The
different therapeutic activities of medicinal plants (antioxidants, antiinflammatory,
anti-carcinogenic, antimicrobial, anti-malarial, anticholinergic, hypoglycemic, antileprosy, and antidiabetic) are basically attributed to the bioactive principles.
Polyphenols, phytosterols, carotenoids, prebiotics, vitamins, and flavonoids are effectively used in treating EDCs induced diabetes mellitus, hypertension obesity, hyperlipidemia, and non-alcoholic fatty liver disease.
T. H. Mallhi · Y. H. Khan (*) · A. I. Alzarea
Department of Clinical Pharmacy, College of Pharmacy, Jouf University,
Sakaka, Al-Jouf, Kingdom of Saudi Arabia
M. Rasheed
Institute of Pharmacy, Lahore College for Women University, Lahore, Pakistan
A. A. Raja
School of Pharmacy, Taylor’s University, Subang Jaya, Selangor, Malaysia
The original version of this chapter has been revised and is now available open access. A correction
to this chapter is available at https://doi.org/10.1007/978-3-030-45923-9_29
, Corrected Publication 2021
© The Editor(s) (if applicable) and The Author(s), under exclusive license
to Springer Nature Switzerland AG 2021
M. S. H. Akash et al. (eds.), Endocrine Disrupting Chemicals-induced
Metabolic Disorders and Treatment Strategies, Emerging Contaminants
and Associated Treatment Technologies,
https://doi.org/10.1007/978-3-030-45923-9_28
Chapter 28
Bioactive Compounds for the Treatment
of Metabolic Disorders
Tauqeer Hussain Mallhi, Maria Rasheed, Yusra Habib Khan,
Abdulaziz Ibrahim Alzarea, and Ahsan Aftab Raja
Abstract The exposure of endocrine disrupting chemicals results in disruption of
normal energy homeostasis control. Decrease metabolism of carbohydrates, proteins
and fats occur due to EDCs induced thyroid dysfunction. The obesogenic and metabolic dysregulation ability leads to development of metabolic disorders. Plasticizers
(bisphenol A), persistent organic pollutants (dioxins), organotins (tributyltin), and
organochlorines (dichlorodiphenyltrichloroethane) are examples of some EDCs.
There has been an increasing focus to investigate association between human exposure to EDCs and disease over the past few decades. Bioactive compounds are found
to be effective in these EDCs induced metabolic disorders including diabetes mellitus,
hypertension, obesity, hyperlipidemia, and non-alcoholic fatty liver disease. These
compounds obtained from fruits, vegetables, and whole grains exert pharmacological
effects in humans and play important role in defense and signaling. The use of these
compounds is advantageous due to easy availability, safety, and few side effects. The
different therapeutic activities of medicinal plants (antioxidants, antiinflammatory,
anti-carcinogenic, antimicrobial, anti-malarial, anticholinergic, hypoglycemic, antileprosy, and antidiabetic) are basically attributed to the bioactive principles.
Polyphenols, phytosterols, carotenoids, prebiotics, vitamins, and flavonoids are effectively used in treating EDCs induced diabetes mellitus, hypertension obesity, hyperlipidemia, and non-alcoholic fatty liver disease.
T. H. Mallhi · Y. H. Khan (*) · A. I. Alzarea
Department of Clinical Pharmacy, College of Pharmacy, Jouf University,
Sakaka, Al-Jouf, Kingdom of Saudi Arabia
M. Rasheed
Institute of Pharmacy, Lahore College for Women University, Lahore, Pakistan
A. A. Raja
School of Pharmacy, Taylor’s University, Subang Jaya, Selangor, Malaysia
The original version of this chapter has been revised and is now available open access. A correction
to this chapter is available at https://doi.org/10.1007/978-3-030-45923-9_29
, Corrected Publication 2021