381
© The Editor(s) (if applicable) and The Author(s), under exclusive license
to Springer Nature Switzerland AG 2021
M. S. H. Akash et al. (eds.), Endocrine Disrupting Chemicals-induced
Metabolic Disorders and Treatment Strategies, Emerging Contaminants
and Associated Treatment Technologies,
https://doi.org/10.1007/978-3-030-45923-9_23
Chapter 23
Role of Aflatoxins as EDCs in Metabolic
Disorders
Shakila Sabir, Kanwal Rehman, Fareeha Fiayyaz, Shagufta Kamal,
and Muhammad Sajid Hamid Akash
Abstract Aflatoxins (AFs) producing fungi (Aspergillus species) are extensively
spread in the environment and widely contaminate the human and animal feed. AF
has been recognized as substituted bisfuranocoumarins, a secondary fungal metabolite. It has been recognized that AFs may cause hepatotoxicity, mutagenicity, nephrotoxicity, genotoxicity, teratogenicity, and immunotoxicity. Therefore, the
International Agency for Research on Cancer has categorized AFs as class I human
carcinogen. AF undergoes phase-I and phase-II metabolism in the liver. AFsmediated cell damage may be due to the production of free radicals. The key mechanism behind AF-induced toxicity is the induction of oxidative stress. AF potentiates
inflammatory responses. Additionally, AFs are also found to be involved in impaired
lipid and carbohydrate metabolism. Although, attention has not been given to AFsinduced metabolic disorders, metabolic abnormalities produced by AFs clearly indicate that AFs may increase the susceptibility to develop metabolic disorders.
Keywords Lipid metabolism · Carbohydrate metabolism · Oxidative stress ·
Aflatoxin metabolism
S. Sabir · M. S. H. Akash (*)
Department of Pharmaceutical Chemistry, Government College University Faisalabad,
Faisalabad, Pakistan
K. Rehman
Department of Pharmacy, University of Agriculture Faisalabad, Faisalabad, Pakistan
F. Fiayyaz
Department of Pharmaceutical Chemistry, Government College University,
Faisalabad, Pakistan
Department of Microbiology, Government College University, Faisalabad, Pakistan
S. Kamal
Department of Biochemistry, Government College University Faisalabad, Faisalabad,
Pakistan
© The Editor(s) (if applicable) and The Author(s), under exclusive license
to Springer Nature Switzerland AG 2021
M. S. H. Akash et al. (eds.), Endocrine Disrupting Chemicals-induced
Metabolic Disorders and Treatment Strategies, Emerging Contaminants
and Associated Treatment Technologies,
https://doi.org/10.1007/978-3-030-45923-9_23
Chapter 23
Role of Aflatoxins as EDCs in Metabolic
Disorders
Shakila Sabir, Kanwal Rehman, Fareeha Fiayyaz, Shagufta Kamal,
and Muhammad Sajid Hamid Akash
Abstract Aflatoxins (AFs) producing fungi (Aspergillus species) are extensively
spread in the environment and widely contaminate the human and animal feed. AF
has been recognized as substituted bisfuranocoumarins, a secondary fungal metabolite. It has been recognized that AFs may cause hepatotoxicity, mutagenicity, nephrotoxicity, genotoxicity, teratogenicity, and immunotoxicity. Therefore, the
International Agency for Research on Cancer has categorized AFs as class I human
carcinogen. AF undergoes phase-I and phase-II metabolism in the liver. AFsmediated cell damage may be due to the production of free radicals. The key mechanism behind AF-induced toxicity is the induction of oxidative stress. AF potentiates
inflammatory responses. Additionally, AFs are also found to be involved in impaired
lipid and carbohydrate metabolism. Although, attention has not been given to AFsinduced metabolic disorders, metabolic abnormalities produced by AFs clearly indicate that AFs may increase the susceptibility to develop metabolic disorders.
Keywords Lipid metabolism · Carbohydrate metabolism · Oxidative stress ·
Aflatoxin metabolism
S. Sabir · M. S. H. Akash (*)
Department of Pharmaceutical Chemistry, Government College University Faisalabad,
Faisalabad, Pakistan
K. Rehman
Department of Pharmacy, University of Agriculture Faisalabad, Faisalabad, Pakistan
F. Fiayyaz
Department of Pharmaceutical Chemistry, Government College University,
Faisalabad, Pakistan
Department of Microbiology, Government College University, Faisalabad, Pakistan
S. Kamal
Department of Biochemistry, Government College University Faisalabad, Faisalabad,
Pakistan