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channels in β-cell membranes, thus result in insulin secretion. The impaired glucose metabolism, hampered intracellular transportation, reduced blood flow, and
receptor down- regulation cause insulin resistance. The hyperglycemic conditions
result in insulin resistance. The alteration in glucose and lipid metabolism due to
medications results in weight gain or T2DM [6, 7].
Medications for Immunosuppression as EDCs
The chances of post-transplant organ rejections are minimized by employing immunosuppression drugs like tacrolimus and cyclosporine. Such immunosuppressive
agents cause insulin resistance and put adverse effects on β-cells, thus could lead to
Fig. 21.1 Common endocrine disrupting chemicals.
Fig. 21.2 Pharmaceutical products as endocrine disrupting chemicals.
21 Role of Pharmaceuticals as EDCs in Metabolic Disorders
channels in β-cell membranes, thus result in insulin secretion. The impaired glucose metabolism, hampered intracellular transportation, reduced blood flow, and
receptor down- regulation cause insulin resistance. The hyperglycemic conditions
result in insulin resistance. The alteration in glucose and lipid metabolism due to
medications results in weight gain or T2DM [6, 7].
Medications for Immunosuppression as EDCs
The chances of post-transplant organ rejections are minimized by employing immunosuppression drugs like tacrolimus and cyclosporine. Such immunosuppressive
agents cause insulin resistance and put adverse effects on β-cells, thus could lead to
Fig. 21.1 Common endocrine disrupting chemicals.
Fig. 21.2 Pharmaceutical products as endocrine disrupting chemicals.
21 Role of Pharmaceuticals as EDCs in Metabolic Disorders