237
80. Guan T, Sun Y, Zhang T, Li T, Li Z, Zhang Y, et al. Simultaneous determination of bisphenol
A and its halogenated analogues in soil by fluorescence polarization assay. J Soils Sediments.
2018;18(3):845–51.
81. Wu S, Ji G, Liu J, Zhang S, Gong Y, Shi L. TBBPA induces developmental toxicity, oxidative stress, and apoptosis in embryos and zebrafish larvae (Danio rerio). Environ Toxicol.
2016;31(10):1241–9.
82. Wang K. Molecular mechanisms of liver injury: apoptosis or necrosis. Exp Toxicol Pathol.
2014;66(8):351–6.
83. Zhang Y, Wang X, Chen C, An J, Shang Y, Li H, et al. Regulation of TBBPA-induced oxidative stress on mitochondrial apoptosis in L02 cells through the Nrf2 signaling pathway.
Chemosphere. 2019;226:463–71.
84. Vasiliu O, Cameron L, Gardiner J, DeGuire P, Karmaus W. Polybrominated biphenyls,
polychlorinated biphenyls, body weight, and incidence of adult-onset diabetes mellitus.
Epidemiology. 2006;17(4):352–9.
85. Bahn AK, Mills JL, Snyder PJ, Gann PH, Houten L, Bialik O, et al. Hypothyroidism in workers exposed to polybrominated biphenyls. N Engl J Med. 1980;302(1):31–3.
86. Fowles JR, Fairbrother A, Baecher-Steppan L, Kerkvliet NI. Immunologic and endocrine effects of the flame-retardant pentabromodiphenyl ether (DE-71) in C57BL/6J mice.
Toxicology. 1994;86(1–2):49–61.
87. Zhou T, Ross DG, DeVito MJ, Crofton KM. Effects of short-term in vivo exposure to polybrominated diphenyl ethers on thyroid hormones and hepatic enzyme activities in weanling
rats. Toxicol Sci. 2001;61(1):76–82.
88. Zhou T, Taylor MM, DeVito MJ, Crofton KM. Developmental exposure to brominated diphenyl ethers results in thyroid hormone disruption. Toxicol Sci. 2002;66(1):105–16.
89. Hallgren S, Sinjari T, Håkansson H, Darnerud P. Effects of polybrominated diphenyl ethers
(PBDEs) and polychlorinated biphenyls (PCBs) on thyroid hormone and vitamin A levels in
rats and mice. Arch Toxicol. 2001;75(4):200–8.
90. Brouwer A, Van den Berg K. Binding of a metabolite of 3, 4, 3′, 4′-tetrachlorobiphenyl to
transthyretin reduces serum vitamin A transport by inhibiting the formation of the protein
complex carrying both retinol and thyroxin. Toxicol Appl Pharmacol. 1986;85(3):301–12.
91. Dunnick JK, Heath JE, Farnell DR, Prejean JD, Haseman JK, Elwell MR. Carcinogenic
activity of the flame retardant, 2, 2-bis (bromomethyl)-1, 3-propanediol in rodents, and
comparison with the carcinogenicity of other NTP brominated chemicals. Toxicol Pathol.
1997;25(6):541–8.
92. Visser T. Pathways of thyroid hormone metabolism. Acta Med Austriaca. 1996;23(1–2):10–6.
93. Schuur AG, Brouwer A, Bergman Å, Coughtrie MW, Visser TJ. Inhibition of thyroid hormone
sulfation by hydroxylated metabolites of polychlorinated biphenyls. Chem Biol Interact.
1998;109(1–3):293–7.
94. Lans MC, Klasson-Wehler E, Willemsen M, Meussen E, Safe S, Brouwer A. Structuredependent, competitive interaction of hydroxy-polychlorobiphenyls,-dibenzo-p-dioxins anddibenzofurans with human transthyretin. Chem Biol Interact. 1993;88(1):7–21.
95. Brouwer A, Morse DC, Lans MC, Gerlienke Schuur A, Murk AJ, Klasson-Wehler E, et al.
Interactions of persistent environmental organohalogens with the thyroid hormone system:
mechanisms and possible consequences for animal and human health. Toxicol Ind Health.
1998;14(1–2):59–84.
96. Morse DC, Wehler EK, Wesseling W, Koeman JH, Brouwer A. Alterations in rat brain thyroid
hormone status following pre-and postnatal exposure to polychlorinated biphenyls (Aroclor
1254). Toxicol Appl Pharmacol. 1996;136(2):269–79.
97. Meerts IATM. In vitro and in vivo interactions of organohalogens with the endocrine system:
the role of metabolites and implications for human health; 2001.
98. Legler J, van den Brink CE, Brouwer A, Murk AJ, van der Saag PT, Vethaak AD, et al.
Development of a stably transfected estrogen receptor-mediated luciferase reporter gene
assay in the human T47D breast cancer cell line. Toxicol Sci. 1999;48(1):55–66.
14 Role of Flame-Retardants as EDCs in Metabolic Disorders
80. Guan T, Sun Y, Zhang T, Li T, Li Z, Zhang Y, et al. Simultaneous determination of bisphenol
A and its halogenated analogues in soil by fluorescence polarization assay. J Soils Sediments.
2018;18(3):845–51.
81. Wu S, Ji G, Liu J, Zhang S, Gong Y, Shi L. TBBPA induces developmental toxicity, oxidative stress, and apoptosis in embryos and zebrafish larvae (Danio rerio). Environ Toxicol.
2016;31(10):1241–9.
82. Wang K. Molecular mechanisms of liver injury: apoptosis or necrosis. Exp Toxicol Pathol.
2014;66(8):351–6.
83. Zhang Y, Wang X, Chen C, An J, Shang Y, Li H, et al. Regulation of TBBPA-induced oxidative stress on mitochondrial apoptosis in L02 cells through the Nrf2 signaling pathway.
Chemosphere. 2019;226:463–71.
84. Vasiliu O, Cameron L, Gardiner J, DeGuire P, Karmaus W. Polybrominated biphenyls,
polychlorinated biphenyls, body weight, and incidence of adult-onset diabetes mellitus.
Epidemiology. 2006;17(4):352–9.
85. Bahn AK, Mills JL, Snyder PJ, Gann PH, Houten L, Bialik O, et al. Hypothyroidism in workers exposed to polybrominated biphenyls. N Engl J Med. 1980;302(1):31–3.
86. Fowles JR, Fairbrother A, Baecher-Steppan L, Kerkvliet NI. Immunologic and endocrine effects of the flame-retardant pentabromodiphenyl ether (DE-71) in C57BL/6J mice.
Toxicology. 1994;86(1–2):49–61.
87. Zhou T, Ross DG, DeVito MJ, Crofton KM. Effects of short-term in vivo exposure to polybrominated diphenyl ethers on thyroid hormones and hepatic enzyme activities in weanling
rats. Toxicol Sci. 2001;61(1):76–82.
88. Zhou T, Taylor MM, DeVito MJ, Crofton KM. Developmental exposure to brominated diphenyl ethers results in thyroid hormone disruption. Toxicol Sci. 2002;66(1):105–16.
89. Hallgren S, Sinjari T, Håkansson H, Darnerud P. Effects of polybrominated diphenyl ethers
(PBDEs) and polychlorinated biphenyls (PCBs) on thyroid hormone and vitamin A levels in
rats and mice. Arch Toxicol. 2001;75(4):200–8.
90. Brouwer A, Van den Berg K. Binding of a metabolite of 3, 4, 3′, 4′-tetrachlorobiphenyl to
transthyretin reduces serum vitamin A transport by inhibiting the formation of the protein
complex carrying both retinol and thyroxin. Toxicol Appl Pharmacol. 1986;85(3):301–12.
91. Dunnick JK, Heath JE, Farnell DR, Prejean JD, Haseman JK, Elwell MR. Carcinogenic
activity of the flame retardant, 2, 2-bis (bromomethyl)-1, 3-propanediol in rodents, and
comparison with the carcinogenicity of other NTP brominated chemicals. Toxicol Pathol.
1997;25(6):541–8.
92. Visser T. Pathways of thyroid hormone metabolism. Acta Med Austriaca. 1996;23(1–2):10–6.
93. Schuur AG, Brouwer A, Bergman Å, Coughtrie MW, Visser TJ. Inhibition of thyroid hormone
sulfation by hydroxylated metabolites of polychlorinated biphenyls. Chem Biol Interact.
1998;109(1–3):293–7.
94. Lans MC, Klasson-Wehler E, Willemsen M, Meussen E, Safe S, Brouwer A. Structuredependent, competitive interaction of hydroxy-polychlorobiphenyls,-dibenzo-p-dioxins anddibenzofurans with human transthyretin. Chem Biol Interact. 1993;88(1):7–21.
95. Brouwer A, Morse DC, Lans MC, Gerlienke Schuur A, Murk AJ, Klasson-Wehler E, et al.
Interactions of persistent environmental organohalogens with the thyroid hormone system:
mechanisms and possible consequences for animal and human health. Toxicol Ind Health.
1998;14(1–2):59–84.
96. Morse DC, Wehler EK, Wesseling W, Koeman JH, Brouwer A. Alterations in rat brain thyroid
hormone status following pre-and postnatal exposure to polychlorinated biphenyls (Aroclor
1254). Toxicol Appl Pharmacol. 1996;136(2):269–79.
97. Meerts IATM. In vitro and in vivo interactions of organohalogens with the endocrine system:
the role of metabolites and implications for human health; 2001.
98. Legler J, van den Brink CE, Brouwer A, Murk AJ, van der Saag PT, Vethaak AD, et al.
Development of a stably transfected estrogen receptor-mediated luciferase reporter gene
assay in the human T47D breast cancer cell line. Toxicol Sci. 1999;48(1):55–66.
14 Role of Flame-Retardants as EDCs in Metabolic Disorders