198
References
1. Diamanti-Kandarakis E, Bourguignon JP, Giudice LC, Hauser R, Prins GS, Soto AM, et al.
Endocrine-disrupting chemicals: an Endocrine Society scientific statement. Endocr Rev.
2009;30(4):293–342.
2. Bolger PM, Tao SS-H, Dinovi M. Hazards of dietary furan. Hoboken: Wiley; 2009. p. 117–33.
3. Vranová J, Ciesarová Z. Furan in food—a review. Czech J Food Sci. 2009;27(1):1–10.
4. Wright DL. Furans as versatile synthons for target-oriented and diversity oriented synthesis.
Prog Heterocycl Chem. 2005;17:1–32.
5. Cancer IAfRo. IARC monographs on the evaluation of carcinogenic risks to humans. Dry
cleaning, some chlorinated solvents and other industrial chemicals. IARC. 1995;63:443–65.
6. Crews C, Castle L. A review of the occurrence, formation and analysis of furan in heatprocessed foods. Trends Food Sci Technol. 2007;18(7):365–72.
7. Bakhiya N, Appel KE. Toxicity and carcinogenicity of furan in human diet. Arch Toxicol.
2010;84(7):563–78.
8. Maga JA, Katz I. Furans in foods. Crit Rev Food Sci Nutr. 1979;11(4):355–400.
9. Santé-Lhoutellier V, Astruc T, Marinova P, Greve E, Gatellier P. Effect of meat cooking on
physicochemical state and in vitro digestibility of myofibrillar proteins. J Agric Food Chem.
2008;56(4):1488–94.
10. Chain EPoCitF, Knutsen HK, Alexander J, Barregård L, Bignami M, Brüschweiler B, et al.
Risks for public health related to the presence of furan and methylfurans in food. EFSA
J. 2017;15(10):e05005.
11. Gill S, Bondy G, Lefebvre DE, Becalski A, Kavanagh M, Hou Y, et al. Subchronic oral toxicity study of furan in Fischer-344 rats. Toxicol Pathol. 2010;38(4):619–30.
12. Gill S, Kavanagh M, Barker M, Weld M, Vavasour E, Hou Y, et al. Subchronic oral toxicity
study of furan in B6C3F1 Mice. Toxicol Pathol. 2011;39(5):787–94.
13. Moser GJ, Foley J, Burnett M, Goldsworthy TL, Maronpot R. Furan-induced dose–response
relationships for liver cytotoxicity, cell proliferation, and tumorigenicity (furan-induced liver
tumorigenicity). Exp Toxicol Pathol. 2009;61(2):101–11.
14. Capurro PU. Effects of exposure to solvents caused by air pollution with special reference to
CCl 4 and its distribution in air. Clin Toxicol. 1973;6(1):109–24.
15. Peterson LA. Reactive metabolites in the biotransformation of molecules containing a furan
ring. Chem Res Toxicol. 2013;26(1):6–25.
16. Maga JA. Furans in foods. CRC Crit Rev Food Sci Nutr. 1979;11(4):355–400.
17. Noce R, Paredes BE, Pichler WJ, Krahenbuhl S. Acute generalized exanthematic pustulosis
(AGEP) in a patient treated with furosemide. Am J Med Sci. 2000;320(5):331–3.
18. Williams DP, Antoine DJ, Butler PJ, Jones R, Randle L, Payne A, et al. The metabolism and
toxicity of furosemide in the Wistar rat and CD-1 mouse: a chemical and biochemical definition of the toxicophore. J Pharmacol Exp Ther. 2007;322(3):1208–20.
19. Erve JC, Vashishtha SC, DeMaio W, Talaat RE. Metabolism of prazosin in rat, dog, and
human liver microsomes and cryopreserved rat and human hepatocytes and characterization
of metabolites by liquid chromatography/tandem mass spectrometry. Drug Metab Dispos.
2007;35(6):908–16.
20. Larrey D, Vial T, Pauwels A, Castot A, Biour M, David M, et al. Hepatitis after germander
(Teucrium chamaedrys) administration: another instance of herbal medicine hepatotoxicity.
Ann Intern Med. 1992;117(2):129–32.
21. Loeper J, Descatoire V, Letteron P, Moulis C, Degott C, Dansette P, et al. Hepatotoxicity of
germander in mice. Gastroenterology. 1994;106(2):464–72.
22. Wangensteen H, Molden E, Christensen H, Malterud KE. Identification of epoxybergamottin
as a CYP3A4 inhibitor in grapefruit peel. Eur J Clin Pharmacol. 2003;58(10):663–8.
23. Edwards DJ, Bellevue FH 3rd, Woster PM. Identification of 6′,7′-dihydroxybergamottin, a
cytochrome P450 inhibitor, in grapefruit juice. Drug Metab Dispos. 1996;24(12):1287–90.
S. Muzammil et al.
References
1. Diamanti-Kandarakis E, Bourguignon JP, Giudice LC, Hauser R, Prins GS, Soto AM, et al.
Endocrine-disrupting chemicals: an Endocrine Society scientific statement. Endocr Rev.
2009;30(4):293–342.
2. Bolger PM, Tao SS-H, Dinovi M. Hazards of dietary furan. Hoboken: Wiley; 2009. p. 117–33.
3. Vranová J, Ciesarová Z. Furan in food—a review. Czech J Food Sci. 2009;27(1):1–10.
4. Wright DL. Furans as versatile synthons for target-oriented and diversity oriented synthesis.
Prog Heterocycl Chem. 2005;17:1–32.
5. Cancer IAfRo. IARC monographs on the evaluation of carcinogenic risks to humans. Dry
cleaning, some chlorinated solvents and other industrial chemicals. IARC. 1995;63:443–65.
6. Crews C, Castle L. A review of the occurrence, formation and analysis of furan in heatprocessed foods. Trends Food Sci Technol. 2007;18(7):365–72.
7. Bakhiya N, Appel KE. Toxicity and carcinogenicity of furan in human diet. Arch Toxicol.
2010;84(7):563–78.
8. Maga JA, Katz I. Furans in foods. Crit Rev Food Sci Nutr. 1979;11(4):355–400.
9. Santé-Lhoutellier V, Astruc T, Marinova P, Greve E, Gatellier P. Effect of meat cooking on
physicochemical state and in vitro digestibility of myofibrillar proteins. J Agric Food Chem.
2008;56(4):1488–94.
10. Chain EPoCitF, Knutsen HK, Alexander J, Barregård L, Bignami M, Brüschweiler B, et al.
Risks for public health related to the presence of furan and methylfurans in food. EFSA
J. 2017;15(10):e05005.
11. Gill S, Bondy G, Lefebvre DE, Becalski A, Kavanagh M, Hou Y, et al. Subchronic oral toxicity study of furan in Fischer-344 rats. Toxicol Pathol. 2010;38(4):619–30.
12. Gill S, Kavanagh M, Barker M, Weld M, Vavasour E, Hou Y, et al. Subchronic oral toxicity
study of furan in B6C3F1 Mice. Toxicol Pathol. 2011;39(5):787–94.
13. Moser GJ, Foley J, Burnett M, Goldsworthy TL, Maronpot R. Furan-induced dose–response
relationships for liver cytotoxicity, cell proliferation, and tumorigenicity (furan-induced liver
tumorigenicity). Exp Toxicol Pathol. 2009;61(2):101–11.
14. Capurro PU. Effects of exposure to solvents caused by air pollution with special reference to
CCl 4 and its distribution in air. Clin Toxicol. 1973;6(1):109–24.
15. Peterson LA. Reactive metabolites in the biotransformation of molecules containing a furan
ring. Chem Res Toxicol. 2013;26(1):6–25.
16. Maga JA. Furans in foods. CRC Crit Rev Food Sci Nutr. 1979;11(4):355–400.
17. Noce R, Paredes BE, Pichler WJ, Krahenbuhl S. Acute generalized exanthematic pustulosis
(AGEP) in a patient treated with furosemide. Am J Med Sci. 2000;320(5):331–3.
18. Williams DP, Antoine DJ, Butler PJ, Jones R, Randle L, Payne A, et al. The metabolism and
toxicity of furosemide in the Wistar rat and CD-1 mouse: a chemical and biochemical definition of the toxicophore. J Pharmacol Exp Ther. 2007;322(3):1208–20.
19. Erve JC, Vashishtha SC, DeMaio W, Talaat RE. Metabolism of prazosin in rat, dog, and
human liver microsomes and cryopreserved rat and human hepatocytes and characterization
of metabolites by liquid chromatography/tandem mass spectrometry. Drug Metab Dispos.
2007;35(6):908–16.
20. Larrey D, Vial T, Pauwels A, Castot A, Biour M, David M, et al. Hepatitis after germander
(Teucrium chamaedrys) administration: another instance of herbal medicine hepatotoxicity.
Ann Intern Med. 1992;117(2):129–32.
21. Loeper J, Descatoire V, Letteron P, Moulis C, Degott C, Dansette P, et al. Hepatotoxicity of
germander in mice. Gastroenterology. 1994;106(2):464–72.
22. Wangensteen H, Molden E, Christensen H, Malterud KE. Identification of epoxybergamottin
as a CYP3A4 inhibitor in grapefruit peel. Eur J Clin Pharmacol. 2003;58(10):663–8.
23. Edwards DJ, Bellevue FH 3rd, Woster PM. Identification of 6′,7′-dihydroxybergamottin, a
cytochrome P450 inhibitor, in grapefruit juice. Drug Metab Dispos. 1996;24(12):1287–90.
S. Muzammil et al.