144
27. Carmody RN, Turnbaugh PJ. Host-microbial interactions in the metabolism of therapeutic and
diet-derived xenobiotics. J Clin Invest. 2014;124(10):4173–81.
28. Donovan SM. Introduction to the special focus issue on the impact of diet on gut microbiota
composition and function and future opportunities for nutritional modulation of the gut microbiome to improve human health. Gut Microbes. 2017;8(2):75–81.
29. Forslund K, Hildebrand F, Nielsen T, Falony G, Le Chatelier E, Sunagawa S, et al. Disentangling
type 2 diabetes and metformin treatment signatures in the human gut microbiota. Nature.
2015;528(7581):262–6.
30. Claus SP, Guillou H, Ellero-Simatos S. The gut microbiota: a major player in the toxicity of
environmental pollutants? NPJ Biofilms Microbiomes. 2016;2:16003.
31. Snedeker SM, Hay AG. Do interactions between gut ecology and environmental chemicals
contribute to obesity and diabetes? Environ Health Perspect. 2011;120(3):332–9.
32. Van de Wiele T, Gallawa CM, Kubachk KM, Creed JT, Basta N, Dayton EA, et al. Arsenic
metabolism by human gut microbiota upon in vitro digestion of contaminated soils. Environ
Health Perspect. 2010;118(7):1004–9.
33. Lu K, Abo RP, Schlieper KA, Graffam ME, Levine S, Wishnok JS, et al. Arsenic exposure
perturbs the gut microbiome and its metabolic profile in mice: an integrated metagenomics and
metabolomics analysis. Environ Health Perspect. 2014;122(3):284–91.
34. Zhang S, Jin Y, Zeng Z, Liu Z, Fu Z. Subchronic exposure of mice to cadmium perturbs their
hepatic energy metabolism and gut microbiome. Chem Res Toxicol. 2015;28(10):2000–9.
35. Ba Q, Li M, Chen P, Huang C, Duan X, Lu L, et al. Sex-dependent effects of cadmium exposure in early life on gut microbiota and fat accumulation in mice. Environ Health Perspect.
2017;125(3):437–46.
36. Wu J, Wen XW, Faulk C, Boehnke K, Zhang H, Dolinoy DC, et al. Perinatal lead exposure
alters gut microbiota composition and results in sex-specific bodyweight increases in adult
mice. Toxicol Sci. 2016;151(2):324–33.
37. Zhang Y, Zhao F, Deng Y, Zhao Y, Ren H. Metagenomic and metabolomic analysis of the toxic
effects of trichloroacetamide-induced gut microbiome and urine metabolome perturbations in
mice. J Proteome Res. 2015;14(4):1752–61.
38. Lai KP, Chung YT, Li R, Wan HT, Wong CC. Bisphenol A alters gut microbiome: comparative
metagenomics analysis. Environ Pollut. 2016;218:923–30.
39. Taylor KW, Novak RF, Anderson HA, Birnbaum LS, Blystone C, DeVito M, et al. Evaluation
of the association between persistent organic pollutants (POPs) and diabetes in epidemiological studies: a national toxicology program workshop review. Environ Health Perspect.
2013;121(7):774–83.
40. Lambert JE, Myslicki JP, Bomhof MR, Belke DD, Shearer J, Reimer RA. Exercise training modifies gut microbiota in normal and diabetic mice. Appl Physiol Nutr Metab. 2015;
40(7):749–52.
41. Chen L, Zhang W, Hua J, Hu C, Lok-Shun Lai N, Qian PY, et al. Dysregulation of intestinal
health by environmental pollutants: involvement of the estrogen receptor and aryl hydrocarbon
receptor. Environ Sci Technol. 2018;52(4):2323–30.
42. Xun L, Topp E, Orser C. Glutathione is the reducing agent for the reductive dehalogenation
of tetrachloro-p-hydroquinone by extracts from a Flavobacterium sp. Biochem Biophys Res
Commun. 1992;182(1):361–6.
43. James-Todd TM, Huang T, Seely EW, Saxena AR. The association between phthalates and
metabolic syndrome: the National Health and Nutrition Examination Survey 2001–2010.
Environ Health Perspect. 2016;15(1):52.
44. James-Todd T, Stahlhut R, Meeker JD, Powell SG, Hauser R, Huang T, et al. Urinary phthalate
metabolite concentrations and diabetes among women in the National Health and Nutrition
Examination Survey (NHANES) 2001–2008. Environ Health Perspect. 2012;120(9):1307–13.
45. Hu J, Raikhel V, Gopalakrishnan K, Fernandez-Hernandez H, Lambertini L, Manservisi F,
et al. Effect of postnatal low-dose exposure to environmental chemicals on the gut microbiome
in a rodent model. Microbiome. 2016;4(1):26.
F. Fiayyaz et al.
27. Carmody RN, Turnbaugh PJ. Host-microbial interactions in the metabolism of therapeutic and
diet-derived xenobiotics. J Clin Invest. 2014;124(10):4173–81.
28. Donovan SM. Introduction to the special focus issue on the impact of diet on gut microbiota
composition and function and future opportunities for nutritional modulation of the gut microbiome to improve human health. Gut Microbes. 2017;8(2):75–81.
29. Forslund K, Hildebrand F, Nielsen T, Falony G, Le Chatelier E, Sunagawa S, et al. Disentangling
type 2 diabetes and metformin treatment signatures in the human gut microbiota. Nature.
2015;528(7581):262–6.
30. Claus SP, Guillou H, Ellero-Simatos S. The gut microbiota: a major player in the toxicity of
environmental pollutants? NPJ Biofilms Microbiomes. 2016;2:16003.
31. Snedeker SM, Hay AG. Do interactions between gut ecology and environmental chemicals
contribute to obesity and diabetes? Environ Health Perspect. 2011;120(3):332–9.
32. Van de Wiele T, Gallawa CM, Kubachk KM, Creed JT, Basta N, Dayton EA, et al. Arsenic
metabolism by human gut microbiota upon in vitro digestion of contaminated soils. Environ
Health Perspect. 2010;118(7):1004–9.
33. Lu K, Abo RP, Schlieper KA, Graffam ME, Levine S, Wishnok JS, et al. Arsenic exposure
perturbs the gut microbiome and its metabolic profile in mice: an integrated metagenomics and
metabolomics analysis. Environ Health Perspect. 2014;122(3):284–91.
34. Zhang S, Jin Y, Zeng Z, Liu Z, Fu Z. Subchronic exposure of mice to cadmium perturbs their
hepatic energy metabolism and gut microbiome. Chem Res Toxicol. 2015;28(10):2000–9.
35. Ba Q, Li M, Chen P, Huang C, Duan X, Lu L, et al. Sex-dependent effects of cadmium exposure in early life on gut microbiota and fat accumulation in mice. Environ Health Perspect.
2017;125(3):437–46.
36. Wu J, Wen XW, Faulk C, Boehnke K, Zhang H, Dolinoy DC, et al. Perinatal lead exposure
alters gut microbiota composition and results in sex-specific bodyweight increases in adult
mice. Toxicol Sci. 2016;151(2):324–33.
37. Zhang Y, Zhao F, Deng Y, Zhao Y, Ren H. Metagenomic and metabolomic analysis of the toxic
effects of trichloroacetamide-induced gut microbiome and urine metabolome perturbations in
mice. J Proteome Res. 2015;14(4):1752–61.
38. Lai KP, Chung YT, Li R, Wan HT, Wong CC. Bisphenol A alters gut microbiome: comparative
metagenomics analysis. Environ Pollut. 2016;218:923–30.
39. Taylor KW, Novak RF, Anderson HA, Birnbaum LS, Blystone C, DeVito M, et al. Evaluation
of the association between persistent organic pollutants (POPs) and diabetes in epidemiological studies: a national toxicology program workshop review. Environ Health Perspect.
2013;121(7):774–83.
40. Lambert JE, Myslicki JP, Bomhof MR, Belke DD, Shearer J, Reimer RA. Exercise training modifies gut microbiota in normal and diabetic mice. Appl Physiol Nutr Metab. 2015;
40(7):749–52.
41. Chen L, Zhang W, Hua J, Hu C, Lok-Shun Lai N, Qian PY, et al. Dysregulation of intestinal
health by environmental pollutants: involvement of the estrogen receptor and aryl hydrocarbon
receptor. Environ Sci Technol. 2018;52(4):2323–30.
42. Xun L, Topp E, Orser C. Glutathione is the reducing agent for the reductive dehalogenation
of tetrachloro-p-hydroquinone by extracts from a Flavobacterium sp. Biochem Biophys Res
Commun. 1992;182(1):361–6.
43. James-Todd TM, Huang T, Seely EW, Saxena AR. The association between phthalates and
metabolic syndrome: the National Health and Nutrition Examination Survey 2001–2010.
Environ Health Perspect. 2016;15(1):52.
44. James-Todd T, Stahlhut R, Meeker JD, Powell SG, Hauser R, Huang T, et al. Urinary phthalate
metabolite concentrations and diabetes among women in the National Health and Nutrition
Examination Survey (NHANES) 2001–2008. Environ Health Perspect. 2012;120(9):1307–13.
45. Hu J, Raikhel V, Gopalakrishnan K, Fernandez-Hernandez H, Lambertini L, Manservisi F,
et al. Effect of postnatal low-dose exposure to environmental chemicals on the gut microbiome
in a rodent model. Microbiome. 2016;4(1):26.
F. Fiayyaz et al.