135
© The Editor(s) (if applicable) and The Author(s), under exclusive license
to Springer Nature Switzerland AG 2021
M. S. H. Akash et al. (eds.), Endocrine Disrupting Chemicals-induced
Metabolic Disorders and Treatment Strategies, Emerging Contaminants
and Associated Treatment Technologies,
https://doi.org/10.1007/978-3-030-45923-9_9
Chapter 9
Alteration of Gut Microbiota
in EDCs- Induced Metabolic Disorders
Fareeha Fiayyaz, Kanwal Rehman, Hina Sharif, Kanwal Irshad,
Shagufta Kamal, and Muhammad Sajid Hamid Akash
Abstract There are over 10
3
–10
4
microorganisms that inhabit gut microbiome.
Together gut microbiome consists of 150 times more genes as compared to that of
human genome. Therefore, it is considered as an “organ.” Due to several factors gut
dysbiosis occurs and it might result in neurobehavioral, immunological, gastrointestinal disorders, obesity, and diabetes. Changes in gut microbiota favor more pathogenic species and these species can result in producing such kind of host diseases
that produce various factors that have their role in virulence, such as LPS (lipopolysaccharide). One of the most important originating factors that undergo dysbiosis in
gut microbiota is endocrine-disrupting chemicals (EDCs). At present, endocrinedisrupting chemicals are found in many products that are being used in our daily life
including cosmetics, plastic bottles, metal cans, toys, pesticides, and in the production of food. These EDCs impede the synthesis, secretion, transport, elimination,
and activity of many natural hormones. This kind of interfering ability of EDCs can
F. Fiayyaz
Department of Pharmaceutical Chemistry, Government College University,
Faisalabad, Pakistan
Department of Microbiology, Government College University,
Faisalabad, Pakistan
K. Rehman (*)
Department of Pharmacy, University of Agriculture Faisalabad, Faisalabad, Pakistan
H. Sharif · K. Irshad · M. S. H. Akash
Department of Pharmaceutical Chemistry, Government College University Faisalabad,
Faisalabad, Pakistan
S. Kamal
Department of Biochemistry, Government College University Faisalabad,
Faisalabad, Pakistan
© The Editor(s) (if applicable) and The Author(s), under exclusive license
to Springer Nature Switzerland AG 2021
M. S. H. Akash et al. (eds.), Endocrine Disrupting Chemicals-induced
Metabolic Disorders and Treatment Strategies, Emerging Contaminants
and Associated Treatment Technologies,
https://doi.org/10.1007/978-3-030-45923-9_9
Chapter 9
Alteration of Gut Microbiota
in EDCs- Induced Metabolic Disorders
Fareeha Fiayyaz, Kanwal Rehman, Hina Sharif, Kanwal Irshad,
Shagufta Kamal, and Muhammad Sajid Hamid Akash
Abstract There are over 10
3
–10
4
microorganisms that inhabit gut microbiome.
Together gut microbiome consists of 150 times more genes as compared to that of
human genome. Therefore, it is considered as an “organ.” Due to several factors gut
dysbiosis occurs and it might result in neurobehavioral, immunological, gastrointestinal disorders, obesity, and diabetes. Changes in gut microbiota favor more pathogenic species and these species can result in producing such kind of host diseases
that produce various factors that have their role in virulence, such as LPS (lipopolysaccharide). One of the most important originating factors that undergo dysbiosis in
gut microbiota is endocrine-disrupting chemicals (EDCs). At present, endocrinedisrupting chemicals are found in many products that are being used in our daily life
including cosmetics, plastic bottles, metal cans, toys, pesticides, and in the production of food. These EDCs impede the synthesis, secretion, transport, elimination,
and activity of many natural hormones. This kind of interfering ability of EDCs can
F. Fiayyaz
Department of Pharmaceutical Chemistry, Government College University,
Faisalabad, Pakistan
Department of Microbiology, Government College University,
Faisalabad, Pakistan
K. Rehman (*)
Department of Pharmacy, University of Agriculture Faisalabad, Faisalabad, Pakistan
H. Sharif · K. Irshad · M. S. H. Akash
Department of Pharmaceutical Chemistry, Government College University Faisalabad,
Faisalabad, Pakistan
S. Kamal
Department of Biochemistry, Government College University Faisalabad,
Faisalabad, Pakistan