Chapter 22
Piperine: Sources, Properties,
Applications, and Biotechnological
Production
Neetu Sachan, Dilipkumar Pal, and Phool Chandra
Abstract From ancient times, phytopharmaceuticals have played an important role
in the management of human health. Piperine, an alkaloid with the piperidine
nucleus was discovered and isolated by Hans Christian Ørsted, from the fruits of
Piper nigrum. Piperine forms is slightly water soluble and forms monoclinic needles and possess a strong pungent taste. Piperine contains plentiful established
health effects and beneficial therapeutic properties. Cells and enzymes are key
elements in biotechnological processes to carry out a wide variety of very specific
reactions under judicious conditions to produce piperine and their products.
Piperine also serves as bio-enhancers in conjunction with drugs to stimulate drug
molecules’ activity across different routes by improving the drug's bioavailability
across the membrane, raising the drug's effect across conformational interaction,
and working as a drug receptor. In recent years, there has been significant interest in
the use of piperine to treat many illnesses, its health-beneficial effects, and its work
as bio-enhancers. Due to their biological activity, piperine has the potential to be
used in health and medicine.
Keywords Piperine Á Alkaloid Á Piper nigrum Á Bio-enhancers Á Therapeutics Á
Phytopharmaceuticals
N. Sachan (&) Á P. Chandra
School of Pharmaceutical Sciences, IFTM University, Lodhipur Rajput, Delhi Road (NH-24),
Moradabad 244 102, Uttar Pradesh, India
e-mail: neetuphool@gmail.com
D. Pal
Institute of Pharmaceutical Sciences, Guru Ghasidas Viswavidyalaya, Bilaspur-495 009,
Koni, Chhattisgarh, India
© The Author(s), under exclusive license to Springer Nature Switzerland AG 2021
D. Pal and A. K. Nayak (eds.), Bioactive Natural Products
for Pharmaceutical Applications, Advanced Structured Materials 140,
https://doi.org/10.1007/978-3-030-54027-2_22
759
Piperine: Sources, Properties,
Applications, and Biotechnological
Production
Neetu Sachan, Dilipkumar Pal, and Phool Chandra
Abstract From ancient times, phytopharmaceuticals have played an important role
in the management of human health. Piperine, an alkaloid with the piperidine
nucleus was discovered and isolated by Hans Christian Ørsted, from the fruits of
Piper nigrum. Piperine forms is slightly water soluble and forms monoclinic needles and possess a strong pungent taste. Piperine contains plentiful established
health effects and beneficial therapeutic properties. Cells and enzymes are key
elements in biotechnological processes to carry out a wide variety of very specific
reactions under judicious conditions to produce piperine and their products.
Piperine also serves as bio-enhancers in conjunction with drugs to stimulate drug
molecules’ activity across different routes by improving the drug's bioavailability
across the membrane, raising the drug's effect across conformational interaction,
and working as a drug receptor. In recent years, there has been significant interest in
the use of piperine to treat many illnesses, its health-beneficial effects, and its work
as bio-enhancers. Due to their biological activity, piperine has the potential to be
used in health and medicine.
Keywords Piperine Á Alkaloid Á Piper nigrum Á Bio-enhancers Á Therapeutics Á
Phytopharmaceuticals
N. Sachan (&) Á P. Chandra
School of Pharmaceutical Sciences, IFTM University, Lodhipur Rajput, Delhi Road (NH-24),
Moradabad 244 102, Uttar Pradesh, India
e-mail: neetuphool@gmail.com
D. Pal
Institute of Pharmaceutical Sciences, Guru Ghasidas Viswavidyalaya, Bilaspur-495 009,
Koni, Chhattisgarh, India
© The Author(s), under exclusive license to Springer Nature Switzerland AG 2021
D. Pal and A. K. Nayak (eds.), Bioactive Natural Products
for Pharmaceutical Applications, Advanced Structured Materials 140,
https://doi.org/10.1007/978-3-030-54027-2_22
759