20.4 Conclusion
Enhancement in stability and bioavailability of phytochemicals has been one of the
most important challenges in their effective utilization. Thousands of bioactive
compounds have been isolated and characterized over the years; however, their
therapeutic effectiveness in vivo is often limited by their poor physicochemical
properties and modest oral absorption. Several studies have demonstrated that
encapsulation into various micro-and nanoplatforms is capable of alleviating such
obstacle. Microencapsulation techniques have been proven and commonly
employed method for such enhancement. Novel techniques like hydrogels and their
variants such as emulsion gels, organo gels, and bigels along with electrodynamic
processes like electrospraying and electrospinning techniques are certainly
promising approaches to facilitate the effective delivery of these bioactive
compounds.
References
Abaee A, Mohammadian M, Jafari SM (2017) Whey and soy protein-based hydrogels and
nano-hydrogels as bioactive delivery systems. Trend Food Sci Technol 70:69–81
Aditya NP, Hamilton IE, Noon J, Norton IT (2019) Microwave assisted nanonization of poorly
water-soluble curcumin. ACS Sustain Chem Eng 7:9771–9781
Aguiar GPS, Arcari BD, Chaves LMPC, Magro CD, Boschetto DL, Piato AL et al (2018)
Micronization of trans-resveratrol by supercritical fluid: dissolution, solubility and in vitro
antioxidant activity. Ind Crop Prod 112:1–5
Ahmed K, Li Y, McClements DJ, Xiao H (2012) Nanoemulsion-and emulsion-based delivery
systems for curcumin: encapsulation and release properties. Food Chem 132:799–807
Ajazuddin and Saraf S (2010) Applications of novel drug delivery system for herbal formulations,
Fitoterapia 81: 680–689
Akbari A, Wu J (2016) Cruciferin nanoparticles: Preparation, characterization and their potential
application in delivery of bioactive compounds. Food Hydrocolloid 54:107–118
Akhavan S, Assadpour E, Katouzian I, Jafari SM (2018) Lipid nano scale cargos for the protection
and delivery of food bioactive ingredients and nutraceuticals. Trend Food Sci Technol 74:132–
146
Akhtar MF, Hanif M, Ranjha NM (2016) Methods of synthesis of hydrogels. A review, Saudi
Pharm J 24:554–559
Al Juhaimi F, Ozcan MM, Ghafoor K, Babiker EE, Hussain S (2018) Comparison of cold-pressing
and soxhlet extraction systems for bioactive compounds, antioxidant properties, polyphenols,
fatty acids and tocopherols in eight nut oils. J Food Sci Technol 55:3163–3173
Alborzi S, Lim LT, Kakuda Y (2012) Encapsulation of folic acid and its stability in sodium
alginate-pectin-poly(ethylene oxide) electrospun fibres. J Microencapsul 30:64–71
Alehosseini A, Ghorani B, Sarabi-Jamab M, Tucker N (2018) Principles of electrospraying: a new
approach in protection of bioactive compounds in foods. Crit Rev Food Sci Nutr 58:2346–2363
Alfei S, Turrini F, Catena S, Zunin P, Parodi B, Zuccari G et al (2019) Preparation of ellagic acid
micro and nano formulations with amazingly increased water solubility by its entrapment in
pectin or non-PAMAM dendrimers suitable for clinical applications. New J Chem 43:2438–
2448
20 Encapsulation of Bioactive Compound and Its Therapeutic Potential
705
Enhancement in stability and bioavailability of phytochemicals has been one of the
most important challenges in their effective utilization. Thousands of bioactive
compounds have been isolated and characterized over the years; however, their
therapeutic effectiveness in vivo is often limited by their poor physicochemical
properties and modest oral absorption. Several studies have demonstrated that
encapsulation into various micro-and nanoplatforms is capable of alleviating such
obstacle. Microencapsulation techniques have been proven and commonly
employed method for such enhancement. Novel techniques like hydrogels and their
variants such as emulsion gels, organo gels, and bigels along with electrodynamic
processes like electrospraying and electrospinning techniques are certainly
promising approaches to facilitate the effective delivery of these bioactive
compounds.
References
Abaee A, Mohammadian M, Jafari SM (2017) Whey and soy protein-based hydrogels and
nano-hydrogels as bioactive delivery systems. Trend Food Sci Technol 70:69–81
Aditya NP, Hamilton IE, Noon J, Norton IT (2019) Microwave assisted nanonization of poorly
water-soluble curcumin. ACS Sustain Chem Eng 7:9771–9781
Aguiar GPS, Arcari BD, Chaves LMPC, Magro CD, Boschetto DL, Piato AL et al (2018)
Micronization of trans-resveratrol by supercritical fluid: dissolution, solubility and in vitro
antioxidant activity. Ind Crop Prod 112:1–5
Ahmed K, Li Y, McClements DJ, Xiao H (2012) Nanoemulsion-and emulsion-based delivery
systems for curcumin: encapsulation and release properties. Food Chem 132:799–807
Ajazuddin and Saraf S (2010) Applications of novel drug delivery system for herbal formulations,
Fitoterapia 81: 680–689
Akbari A, Wu J (2016) Cruciferin nanoparticles: Preparation, characterization and their potential
application in delivery of bioactive compounds. Food Hydrocolloid 54:107–118
Akhavan S, Assadpour E, Katouzian I, Jafari SM (2018) Lipid nano scale cargos for the protection
and delivery of food bioactive ingredients and nutraceuticals. Trend Food Sci Technol 74:132–
146
Akhtar MF, Hanif M, Ranjha NM (2016) Methods of synthesis of hydrogels. A review, Saudi
Pharm J 24:554–559
Al Juhaimi F, Ozcan MM, Ghafoor K, Babiker EE, Hussain S (2018) Comparison of cold-pressing
and soxhlet extraction systems for bioactive compounds, antioxidant properties, polyphenols,
fatty acids and tocopherols in eight nut oils. J Food Sci Technol 55:3163–3173
Alborzi S, Lim LT, Kakuda Y (2012) Encapsulation of folic acid and its stability in sodium
alginate-pectin-poly(ethylene oxide) electrospun fibres. J Microencapsul 30:64–71
Alehosseini A, Ghorani B, Sarabi-Jamab M, Tucker N (2018) Principles of electrospraying: a new
approach in protection of bioactive compounds in foods. Crit Rev Food Sci Nutr 58:2346–2363
Alfei S, Turrini F, Catena S, Zunin P, Parodi B, Zuccari G et al (2019) Preparation of ellagic acid
micro and nano formulations with amazingly increased water solubility by its entrapment in
pectin or non-PAMAM dendrimers suitable for clinical applications. New J Chem 43:2438–
2448
20 Encapsulation of Bioactive Compound and Its Therapeutic Potential
705