TRANSLOCATION
Tetracosahexaenoic acid 24:6
beta- oxidation,
AcylCoA oxidase
Thiolases
Bif unctional protein HSD 1784
C
OH
O
PEROXISOMES
Docosahexenoic acid 22:6
C
O
OH
C
OH
O
delta6- desaturase
(FADS2)
O2 + NADH+ H+
(2)H2O +NAD+
alpha-linolienic acid
(ALA) 18:3
stearidonic acid 18:4
malonyl-CoA
CoASH
ER-mediated elongation
Eicosatetraenoic acid 20:4
delta6- desaturase
(FADS1)
O2 + NADH+ H+
(2)H2O +NAD+
C
O
OH
Eicosapentenoic acid ( EPA)
omega-3 PUFA 20:5
ER-mediated elongation
ELOVL2, ELVOL5
ELOVL2,ELOVL5
Docospentaenoic acid (DPA)
22:5
ER-mediated elongation
ELOVL2,ELOVL5
Tetracospentaenoic acid 24:5
Tetracosahexaemic acid 24:6
Fig. 17.1 Synthesis process of eicosapentenoic acid and docosahexenoic acid
592
D. Pal and K. Raj