In a nutshell, diverse pharmaceutical application of Alstonia genus-derived
phytochemicals indicates that a proper evaluation might result in the development
of various drug/drug candidates for diverse pharmaceutical applications.
References
Abinaya M, Gayathri M (2019) Inhibition of biofilm formation, quorum sensing activity and
molecular docking study of isolated 3, 5, 7-Trihydroxyflavone from Alstonia scholaris leaf
against P. aeruginosa. Bioorg Chem 87:291–301
Addington OC, Newman RA (2017) With the method for Alstonia species or the extract for
treating nervous disorders of Luckynut Thevetia Seed species, CN107412775A
Adotey JPK, Adukpo GE, Opoku Boahen Y, Armah FA (2012) A review of the ethnobotany and
pharmacological importance of Alstonia boonei De Wild (Apocynaceae). ISRN Pharmacol
2012:1–9
Arai H, Hirasawa Y, Rahman A, Kusumawati I (2010) Alstiphyllanines E-H, picraline and
ajmaline-type alkaloids from Alstonia macrophylla inhibiting sodium glucose cotransporter.
Bioorg Med Chem 18:2152–2158
Arai H, Zaima K, Mitsuta E et al (2012) Alstiphyllanines I-O, ajmaline type alkaloids from
Alstonia macrophylla showing vasorelaxant activity. Bioorg Med Chem 20:3454–3459
Balogun OS, Ajayi OS, Agberotimi BJ (2016) A cytotoxic indole alkaloid from Alstonia boonei.
J Biol Act Prod from Nat 6:347–351
Bhattacharya S, Ray A, Dutta S (1975) Psychopharmacological investigations of the 4-methoxy
indole alkaloids of Alstonia venenata. Planta Med 27:164–170
Cai X, Shang J, Feng T, Luo XD (2010a) Novel alkaloids from Alstonia scholaris. Zeitschrift für
Naturforsch B 65:1164–1168
Cai XH, Zeng CX, Feng T et al (2010b) Monoterpenoid indole alkaloids from Alstonia mairei.
Helv Chim Acta 93:2037–2044
Cai XH, Bao MF, Zhang Y et al (2011) A new type of monoterpenoid indole alkaloid precursor
from Alstonia rostrata. Org Lett 13:3568–3571
Cao P, Liang Y, Gao X et al (2012) Monoterpenoid indole alkaloids from Alstonia yunnanensis
and their cytotoxic and anti-inflammatory activities. Molecules 17:13631–13641
Cao J, Shen H, Wang Q et al (2016) Characterization of chemical constituents and rats metabolites
of an alkaloidal extract of Alstonia scholaris leaves by liquid chromatography coupled with
mass spectrometry. J Chromatogr B 1026:43–45
Carroll AR, Hyde E, Smith J et al (2005) Actinophyllic acid, a potent indole alkaloid inhibitor of
the coupled enzyme assay carboxypeptidase U/hippuricase from the leaves of Alstonia
actinophylla (Apocynaceae). J Org Chem 70:1096–1099
Changwichit K, Khorana N, Suwanborirux K (2011) Bisindole alkaloids and secoiridoids from
Alstonia macrophylla Wall. ex G. Don. Fitoterapia 82:798–804
Chatterjee C, Dey PK (1964) Effect of few neuroleptic phytochemical agents on the serotonin
content in mouse brain. Naturwissenschaften 51:466
Chattopadhyay D, Dungdung S, AB M (2005) A potent sperm motility-inhibiting activity of
bioflavonoids from an ethnomedicine of Onge, Alstonia macrophylla Wall ex A. DC, leaf
extract. Contraception 71:372–378
Cheenpracha S, Ritthiwigrom T, Laphookhieo S (2013) Alstoniaphyllines A-C, unusual
nitrogenous derivatives from the bark of Alstonia macrophylla. J Nat Prod 76:723–726
Cimanga RK, Nsaka SL, Tshodi ME et al (2019) In vitro and in vivo antiplasmodial activity of
extracts and isolated constituents of Alstonia congensis root bark. J Ethnopharmacol
242:111736
14 Pharmaceutical Application of Bio-actives …
529
phytochemicals indicates that a proper evaluation might result in the development
of various drug/drug candidates for diverse pharmaceutical applications.
References
Abinaya M, Gayathri M (2019) Inhibition of biofilm formation, quorum sensing activity and
molecular docking study of isolated 3, 5, 7-Trihydroxyflavone from Alstonia scholaris leaf
against P. aeruginosa. Bioorg Chem 87:291–301
Addington OC, Newman RA (2017) With the method for Alstonia species or the extract for
treating nervous disorders of Luckynut Thevetia Seed species, CN107412775A
Adotey JPK, Adukpo GE, Opoku Boahen Y, Armah FA (2012) A review of the ethnobotany and
pharmacological importance of Alstonia boonei De Wild (Apocynaceae). ISRN Pharmacol
2012:1–9
Arai H, Hirasawa Y, Rahman A, Kusumawati I (2010) Alstiphyllanines E-H, picraline and
ajmaline-type alkaloids from Alstonia macrophylla inhibiting sodium glucose cotransporter.
Bioorg Med Chem 18:2152–2158
Arai H, Zaima K, Mitsuta E et al (2012) Alstiphyllanines I-O, ajmaline type alkaloids from
Alstonia macrophylla showing vasorelaxant activity. Bioorg Med Chem 20:3454–3459
Balogun OS, Ajayi OS, Agberotimi BJ (2016) A cytotoxic indole alkaloid from Alstonia boonei.
J Biol Act Prod from Nat 6:347–351
Bhattacharya S, Ray A, Dutta S (1975) Psychopharmacological investigations of the 4-methoxy
indole alkaloids of Alstonia venenata. Planta Med 27:164–170
Cai X, Shang J, Feng T, Luo XD (2010a) Novel alkaloids from Alstonia scholaris. Zeitschrift für
Naturforsch B 65:1164–1168
Cai XH, Zeng CX, Feng T et al (2010b) Monoterpenoid indole alkaloids from Alstonia mairei.
Helv Chim Acta 93:2037–2044
Cai XH, Bao MF, Zhang Y et al (2011) A new type of monoterpenoid indole alkaloid precursor
from Alstonia rostrata. Org Lett 13:3568–3571
Cao P, Liang Y, Gao X et al (2012) Monoterpenoid indole alkaloids from Alstonia yunnanensis
and their cytotoxic and anti-inflammatory activities. Molecules 17:13631–13641
Cao J, Shen H, Wang Q et al (2016) Characterization of chemical constituents and rats metabolites
of an alkaloidal extract of Alstonia scholaris leaves by liquid chromatography coupled with
mass spectrometry. J Chromatogr B 1026:43–45
Carroll AR, Hyde E, Smith J et al (2005) Actinophyllic acid, a potent indole alkaloid inhibitor of
the coupled enzyme assay carboxypeptidase U/hippuricase from the leaves of Alstonia
actinophylla (Apocynaceae). J Org Chem 70:1096–1099
Changwichit K, Khorana N, Suwanborirux K (2011) Bisindole alkaloids and secoiridoids from
Alstonia macrophylla Wall. ex G. Don. Fitoterapia 82:798–804
Chatterjee C, Dey PK (1964) Effect of few neuroleptic phytochemical agents on the serotonin
content in mouse brain. Naturwissenschaften 51:466
Chattopadhyay D, Dungdung S, AB M (2005) A potent sperm motility-inhibiting activity of
bioflavonoids from an ethnomedicine of Onge, Alstonia macrophylla Wall ex A. DC, leaf
extract. Contraception 71:372–378
Cheenpracha S, Ritthiwigrom T, Laphookhieo S (2013) Alstoniaphyllines A-C, unusual
nitrogenous derivatives from the bark of Alstonia macrophylla. J Nat Prod 76:723–726
Cimanga RK, Nsaka SL, Tshodi ME et al (2019) In vitro and in vivo antiplasmodial activity of
extracts and isolated constituents of Alstonia congensis root bark. J Ethnopharmacol
242:111736
14 Pharmaceutical Application of Bio-actives …
529