14.3.4.3 Serine Protease Inhibitory Potential
Rajic et al. reported the serine protease (trypsin and chymotrypsin) inhibition
potential of triterpenoids (38, 39, 215–218) from the barks and roots of A. boonei
(Fig. 14.42) (Rajic et al. 2000). In the case of trypsin inhibition, lupeol palmitate
(217) exhibited a higher potential (IC 50 = 6.0 µM, with a K i value of 10.4 µM)
-amyrin palmitate (215)
O
O
Fig. 14.41 Chemical structure of a-amyrin palmitate (215)
-Amyrin linoleate (216)
O
O
Lupeol palmitate (217)
O
O
Lupeol linoleate (218)
O
O
Fig. 14.42 Chemical structures of various triterpenoids A. boonei (216–218)
14 Pharmaceutical Application of Bio-actives …
503
Rajic et al. reported the serine protease (trypsin and chymotrypsin) inhibition
potential of triterpenoids (38, 39, 215–218) from the barks and roots of A. boonei
(Fig. 14.42) (Rajic et al. 2000). In the case of trypsin inhibition, lupeol palmitate
(217) exhibited a higher potential (IC 50 = 6.0 µM, with a K i value of 10.4 µM)
-amyrin palmitate (215)
O
O
Fig. 14.41 Chemical structure of a-amyrin palmitate (215)
-Amyrin linoleate (216)
O
O
Lupeol palmitate (217)
O
O
Lupeol linoleate (218)
O
O
Fig. 14.42 Chemical structures of various triterpenoids A. boonei (216–218)
14 Pharmaceutical Application of Bio-actives …
503