Chapter 12
Antimicrobial Application Potential
of Phytoconstituents from Turmeric
and Garlic
Shiv Kumar Prajapati, Gaurav Mishra, Akanksha Malaiya,
Ankit Jain, Nishi Mody, and Ashok M. Raichur
Abstract In recent years, natural phytochemicals are gaining much attention for
their antimicrobial potential. Garlic and turmeric are most widely used from the
natural source, and their constituents directly or indirectly provide various health
benefits, especially due to antimicrobial potential. Though the conventional
antimicrobial compounds are effective against various pathogens, up till now there
is a necessity of effective agents against MDR pathogens. Phytochemicals have
been used for their antimicrobial potential from ancient times. These phytochemicals can work by multiple mechanisms, such as by inhibiting target modifying and
drug degrading enzymes or as efflux pump inhibitors. The use of natural phytoconstituents (e.g., curcumin from turmeric and allicin from garlic) from these two
medicinal plants may be an alternative strategy and can overcome the side effects
associated with antibiotics or other allopathic means of treatment. A wide range of
indications has revealed the therapeutic efficacy of these compounds on bacterial,
S. K. Prajapati Á A. Malaiya
Department of Pharmaceutical Sciences, Bhagyoday Tirth Pharmacy College,
Sagar 470002, MP, India
e-mail: shivprajapati1992@gmail.com
A. Malaiya
e-mail: jain.akanksha2107@gmail.com
G. Mishra
Faculty of Ayurveda, Department of Medicinal Chemistry, Institute of Medical Sciences,
Banaras Hindu University, Varanasi 221005, UP, India
e-mail: vatsgaurav880@gmail.com
A. Jain (&) Á A. M. Raichur
Department of Materials Engineering, Indian Institute of Science, Bangalore 560012,
Karnataka, India
e-mail: ankitjainsagar@gmail.com
A. M. Raichur
e-mail: amr@iisc.ac.in
N. Mody
Department of Pharmaceutical Sciences, Dr. Harisingh Gour Central University,
Sagar 470003, MP, India
e-mail: nishimody@gmail.com
© The Author(s), under exclusive license to Springer Nature Switzerland AG 2021
D. Pal and A. K. Nayak (eds.), Bioactive Natural Products
for Pharmaceutical Applications, Advanced Structured Materials 140,
https://doi.org/10.1007/978-3-030-54027-2_12
409
Antimicrobial Application Potential
of Phytoconstituents from Turmeric
and Garlic
Shiv Kumar Prajapati, Gaurav Mishra, Akanksha Malaiya,
Ankit Jain, Nishi Mody, and Ashok M. Raichur
Abstract In recent years, natural phytochemicals are gaining much attention for
their antimicrobial potential. Garlic and turmeric are most widely used from the
natural source, and their constituents directly or indirectly provide various health
benefits, especially due to antimicrobial potential. Though the conventional
antimicrobial compounds are effective against various pathogens, up till now there
is a necessity of effective agents against MDR pathogens. Phytochemicals have
been used for their antimicrobial potential from ancient times. These phytochemicals can work by multiple mechanisms, such as by inhibiting target modifying and
drug degrading enzymes or as efflux pump inhibitors. The use of natural phytoconstituents (e.g., curcumin from turmeric and allicin from garlic) from these two
medicinal plants may be an alternative strategy and can overcome the side effects
associated with antibiotics or other allopathic means of treatment. A wide range of
indications has revealed the therapeutic efficacy of these compounds on bacterial,
S. K. Prajapati Á A. Malaiya
Department of Pharmaceutical Sciences, Bhagyoday Tirth Pharmacy College,
Sagar 470002, MP, India
e-mail: shivprajapati1992@gmail.com
A. Malaiya
e-mail: jain.akanksha2107@gmail.com
G. Mishra
Faculty of Ayurveda, Department of Medicinal Chemistry, Institute of Medical Sciences,
Banaras Hindu University, Varanasi 221005, UP, India
e-mail: vatsgaurav880@gmail.com
A. Jain (&) Á A. M. Raichur
Department of Materials Engineering, Indian Institute of Science, Bangalore 560012,
Karnataka, India
e-mail: ankitjainsagar@gmail.com
A. M. Raichur
e-mail: amr@iisc.ac.in
N. Mody
Department of Pharmaceutical Sciences, Dr. Harisingh Gour Central University,
Sagar 470003, MP, India
e-mail: nishimody@gmail.com
© The Author(s), under exclusive license to Springer Nature Switzerland AG 2021
D. Pal and A. K. Nayak (eds.), Bioactive Natural Products
for Pharmaceutical Applications, Advanced Structured Materials 140,
https://doi.org/10.1007/978-3-030-54027-2_12
409