11.5.5 Hepatoprotective Potential
Hepatoprotective ability of fenugreek seed extract was investigated for ethanol
induced hepatic injury and apoptosis rats by Kaviarasan and Anuradha (2007).
Upregulation of liver dysfunction markers (alanine aminotransferase (ALT),
gamma-glutamyl transferase (GGT), lactate dehydrogenase (LDH), aspartate
aminotransferase (AST), alkaline phosphatase (ALP) and bilirubin) in plasma and
declined liver glycogen were noticed in rats with chronic ethanol administration
(6 g/kg/day) for 60 days. Ethanol administration altered the activities of alcohol
metabolizing enzymes. Treatment with polyphenolic extract of fenugreek seed
restored the level of liver injury markers to normal levels and this result was compared with silymarin, a hepatoprotective agent (Kaviarasan and Anuradha 2007).
Belaïd-Nouira et al. (2013) observed fenugreek seed powder (5% in diet) efficacy to cure hepatic toxicity due to the oral exposure of AlCl 3 (500 mg/kg bw i.g.
for one month then 1600 ppm via drinking water) in Wistar rats by preventing the
liver weight loss and ameliorating liver dysfunction factors. Regeneration of hepatic
cells, management of iron, glucose and lipid metabolism may be the proposed
mechanism behind the efficient activity of fenugreek seed extract to cure the hepatic
disease (Belaïd-Nouira et al. 2013). Fenugreek seed extract stimulate the liver
function and regenerate the liver cells. Thus it can be used as potential pharmaceutical alternative to treat hepatic diseases (Fig. 11.3).
11.6 Conclusion and Future Perspectives
In this review, we have outlined numerous applications of fenugreek gum as a
potential excipient and therapeutic agent for various biopharmaceutical usage.
Chemists and biologists can access fundamentals of rheological, toxicological and
bio-macromolecular characteristics of fenugreek gum to design a proactive excipient which can enhance the drug discovery strategies in scalable manner to fabricate
cost-effective lifesaving drugs. Indeed, excellent work of industry-academia
researches have introduced this biopolymer as one of the prime excipient for the
Fig. 11.3 Hepato-protective mechanism of fenugreek-based seed extract
11 Pharmaceutical and Therapeutic Applications of Fenugreek Gum
401
Hepatoprotective ability of fenugreek seed extract was investigated for ethanol
induced hepatic injury and apoptosis rats by Kaviarasan and Anuradha (2007).
Upregulation of liver dysfunction markers (alanine aminotransferase (ALT),
gamma-glutamyl transferase (GGT), lactate dehydrogenase (LDH), aspartate
aminotransferase (AST), alkaline phosphatase (ALP) and bilirubin) in plasma and
declined liver glycogen were noticed in rats with chronic ethanol administration
(6 g/kg/day) for 60 days. Ethanol administration altered the activities of alcohol
metabolizing enzymes. Treatment with polyphenolic extract of fenugreek seed
restored the level of liver injury markers to normal levels and this result was compared with silymarin, a hepatoprotective agent (Kaviarasan and Anuradha 2007).
Belaïd-Nouira et al. (2013) observed fenugreek seed powder (5% in diet) efficacy to cure hepatic toxicity due to the oral exposure of AlCl 3 (500 mg/kg bw i.g.
for one month then 1600 ppm via drinking water) in Wistar rats by preventing the
liver weight loss and ameliorating liver dysfunction factors. Regeneration of hepatic
cells, management of iron, glucose and lipid metabolism may be the proposed
mechanism behind the efficient activity of fenugreek seed extract to cure the hepatic
disease (Belaïd-Nouira et al. 2013). Fenugreek seed extract stimulate the liver
function and regenerate the liver cells. Thus it can be used as potential pharmaceutical alternative to treat hepatic diseases (Fig. 11.3).
11.6 Conclusion and Future Perspectives
In this review, we have outlined numerous applications of fenugreek gum as a
potential excipient and therapeutic agent for various biopharmaceutical usage.
Chemists and biologists can access fundamentals of rheological, toxicological and
bio-macromolecular characteristics of fenugreek gum to design a proactive excipient which can enhance the drug discovery strategies in scalable manner to fabricate
cost-effective lifesaving drugs. Indeed, excellent work of industry-academia
researches have introduced this biopolymer as one of the prime excipient for the
Fig. 11.3 Hepato-protective mechanism of fenugreek-based seed extract
11 Pharmaceutical and Therapeutic Applications of Fenugreek Gum
401