11.4 Fenugreek Gum as a Pharmaceutical Excipient
11.4.1 Retarding Agent
The release of therapeutic agent from the oral delivery system depends on the
physicochemical properties of both polymer and drug used in the formulation. The
drug release rate can be manipulated by using a combination of hydrophilic or
hydrophobic polymers and varying their concentrations (Gade and Murthy 2014).
Features of fenugreek gum as a retarding polymer was evaluated by Sav et al. 2013.
Both fenugreek gum and its hydrophobic derivative octenylsuccinate anhydride
fenugreek gum was used to prepare extended release tablets of metoprolol succinate
and carbamazepine as hydrophilic and hydrophobic drug, respectively. The
development of extended release tablet formulations displays similar drug release
kinetics like marketed formulations, viz., Seloken
® XL 50 mg and Tegretal
® 200
CR (Sav et al. 2013). It is imperative to mention that controlled drug release can be
accomplished not only by chemical alteration of fenugreek gum but also by using
various copolymers to enhance unchanged drug concentration in the systemic circulation of poorly bioavailable drugs.
11.4.2 Super-disintegrating Agent
Oral route of administration plays a pivotal role in drug delivery due to simple
administration, less patient complication and efficient dosing (Bhowmik et al.
2009). Tablets and capsules are common dosage form to be administered through
Fig. 11.2 Numerous applications of fenugreek gum
11 Pharmaceutical and Therapeutic Applications of Fenugreek Gum
391
11.4.1 Retarding Agent
The release of therapeutic agent from the oral delivery system depends on the
physicochemical properties of both polymer and drug used in the formulation. The
drug release rate can be manipulated by using a combination of hydrophilic or
hydrophobic polymers and varying their concentrations (Gade and Murthy 2014).
Features of fenugreek gum as a retarding polymer was evaluated by Sav et al. 2013.
Both fenugreek gum and its hydrophobic derivative octenylsuccinate anhydride
fenugreek gum was used to prepare extended release tablets of metoprolol succinate
and carbamazepine as hydrophilic and hydrophobic drug, respectively. The
development of extended release tablet formulations displays similar drug release
kinetics like marketed formulations, viz., Seloken
® XL 50 mg and Tegretal
® 200
CR (Sav et al. 2013). It is imperative to mention that controlled drug release can be
accomplished not only by chemical alteration of fenugreek gum but also by using
various copolymers to enhance unchanged drug concentration in the systemic circulation of poorly bioavailable drugs.
11.4.2 Super-disintegrating Agent
Oral route of administration plays a pivotal role in drug delivery due to simple
administration, less patient complication and efficient dosing (Bhowmik et al.
2009). Tablets and capsules are common dosage form to be administered through
Fig. 11.2 Numerous applications of fenugreek gum
11 Pharmaceutical and Therapeutic Applications of Fenugreek Gum
391