Newman DJ, Cragg GM (2012) Natural products as sources of new drugs over the 30 years from
1981 to 2010. J Nat Prod 75:311–335
Newman DJ, Cragg GM, Kingston DG (2011) Anticancer agents from natural products. CRC
Press Taylor & Francis, Boca Ratan
Nwaeburu CC, Bauer N, Zhao Z, Abukiwan A, Gladkich J, Benner A, Herr I (2016) Up-regulation
of microRNA Let-7c by quercetin inhibits pancreatic cancer progression by activation of
Numbl. Oncotarget 7:58367–58380
Oh JH, Ban JO, Cho M-C, Jo M, Jung JK, Ahn B, Yoon D-Y, Han SB, Hong JT (2012)
4-O-methylhonokiol inhibits colon tumor growth via p21-mediated suppression of NF-kB
activity. J Nutr Biochem 23:706–715
Omar HA, Sargeant AM, Weng J-R, Wang D, Kulp SK, Patel T, Chen C-S (2009) Targeting of the
Akt-nuclear factor-kB signaling network by [1-(4-chloro-3-nitrobenzenesulfonyl)1H-indol-3-yl]-methanol (OSU-A9), a novel indole-3-carbinol derivative, in a mouse model
of hepatocellular carcinoma. Mol Pharmacol 76:957–968
Opipari AW, Tan L, Boitano AE, Sorenson DR, Aurora A, Liu JR (2004) Resveratrol-induced
autophagocytosis in ovarian cancer cells. Cancer Res 64:696–703
Park W, Amin AR, Chen ZG, Shin DM (2013) New perspectives of curcumin in cancer
prevention. Cancer Prev Res 6:387–400
Purnamasari R, Winarni D, Permanasari AA, Agustina E, Hayaza S, Darmanto W (2019)
Anticancer activity of methanol extract of Ficus carica leaves and fruits against proliferation,
apoptosis, and necrosis in Huh7it cells. Cancer Inform 18:1176935119842576
Rahal A, Kumar A, Singh V, Yadav B, Tiwari R, Chakraborty S, Dhama K (2014) Oxidative
stress, prooxidants, and antioxidants: the interplay. BioMed Res Int 2014:761264
Rahman KW, Li Y, Sarkar FH (2004) Inactivation of Akt and NF-kB play important roles during
indole-3-carbinol-induced apoptosis in breast cancer cells. Nutr Cancer 48:84–94
Rao YK, Geethangili M, Fang S-H, Tzeng Y-M (2007) Antioxidant and cytotoxic activities of
naturally occurring phenolic and related compounds: a comparative study. Food Chem Toxicol
45:1770–1776
Ravindranath V, Chandrasekhara N (1980) Absorption and tissue distribution of curcumin in rats.
Toxicology 16:259–265
Rohman A, Riyanto S, Utari D (2006) Antioxidant activities, total phenolic and flavonoid contents
of ethyl acetate extract of Mengkudu (Morinda citrifolia, L) fruit and its fractions. Indones J
Pharm 17:136–142
Russo M, Spagnuolo C, Tedesco I, Russo GL (2010) Phytochemicals in cancer prevention and
therapy: truth or dare? Toxins 2:517–551
Sharma K, Le N, Alotaibi M, Gewirtz DA (2014) Cytotoxic autophagy in cancer therapy. Int J Mol
Sci 15:10034–10051
Slaby O, Sachlova M, Brezkova V, Hezova R, Kovarikova A, Bischofová S, Sevcikova S,
Bienertova-Vasku J, Vasku A, Svoboda M (2013) Identification of microRNAs regulated by
isothiocyanates and association of polymorphisms inside their target sites with risk of sporadic
colorectal cancer. Nutr Cancer 65:247–254
Sonoki H, Sato T, Endo S, Matsunaga T, Yamaguchi M, Yamazaki Y, Sugatani J, Ikari A (2015)
Quercetin decreases claudin-2 expression mediated by up-regulation of microRNA miR-16 in
lung adenocarcinoma A549 cells. Nutrients 7:4578–4592
Spagnuolo C, Russo GL, Orhan IE, Habtemariam S, Daglia M, Sureda A, Nabavi SF, Devi KP,
Loizzo MR, Tundis R, Nabavi SM (2015) Genistein and cancer: current status, challenges, and
future directions. Adv Nutr 6:408–419
Srinivas US, Tan BW, Vellayappan BA, Jeyasekharan AD (2019) ROS and the DNA damage
response in cancer. Redox Biol 25:101084
Takada Y, Andreeff M, Aggarwal BB (2005) Indole-3-carbinol suppresses NF-kB and IkBa kinase
activation, causing inhibition of expression of NF-kB-regulated antiapoptotic and metastatic
gene products and enhancement of apoptosis in myeloid and leukemia cells. Blood 106:641–
649
148
B. Cilwyn et al.
1981 to 2010. J Nat Prod 75:311–335
Newman DJ, Cragg GM, Kingston DG (2011) Anticancer agents from natural products. CRC
Press Taylor & Francis, Boca Ratan
Nwaeburu CC, Bauer N, Zhao Z, Abukiwan A, Gladkich J, Benner A, Herr I (2016) Up-regulation
of microRNA Let-7c by quercetin inhibits pancreatic cancer progression by activation of
Numbl. Oncotarget 7:58367–58380
Oh JH, Ban JO, Cho M-C, Jo M, Jung JK, Ahn B, Yoon D-Y, Han SB, Hong JT (2012)
4-O-methylhonokiol inhibits colon tumor growth via p21-mediated suppression of NF-kB
activity. J Nutr Biochem 23:706–715
Omar HA, Sargeant AM, Weng J-R, Wang D, Kulp SK, Patel T, Chen C-S (2009) Targeting of the
Akt-nuclear factor-kB signaling network by [1-(4-chloro-3-nitrobenzenesulfonyl)1H-indol-3-yl]-methanol (OSU-A9), a novel indole-3-carbinol derivative, in a mouse model
of hepatocellular carcinoma. Mol Pharmacol 76:957–968
Opipari AW, Tan L, Boitano AE, Sorenson DR, Aurora A, Liu JR (2004) Resveratrol-induced
autophagocytosis in ovarian cancer cells. Cancer Res 64:696–703
Park W, Amin AR, Chen ZG, Shin DM (2013) New perspectives of curcumin in cancer
prevention. Cancer Prev Res 6:387–400
Purnamasari R, Winarni D, Permanasari AA, Agustina E, Hayaza S, Darmanto W (2019)
Anticancer activity of methanol extract of Ficus carica leaves and fruits against proliferation,
apoptosis, and necrosis in Huh7it cells. Cancer Inform 18:1176935119842576
Rahal A, Kumar A, Singh V, Yadav B, Tiwari R, Chakraborty S, Dhama K (2014) Oxidative
stress, prooxidants, and antioxidants: the interplay. BioMed Res Int 2014:761264
Rahman KW, Li Y, Sarkar FH (2004) Inactivation of Akt and NF-kB play important roles during
indole-3-carbinol-induced apoptosis in breast cancer cells. Nutr Cancer 48:84–94
Rao YK, Geethangili M, Fang S-H, Tzeng Y-M (2007) Antioxidant and cytotoxic activities of
naturally occurring phenolic and related compounds: a comparative study. Food Chem Toxicol
45:1770–1776
Ravindranath V, Chandrasekhara N (1980) Absorption and tissue distribution of curcumin in rats.
Toxicology 16:259–265
Rohman A, Riyanto S, Utari D (2006) Antioxidant activities, total phenolic and flavonoid contents
of ethyl acetate extract of Mengkudu (Morinda citrifolia, L) fruit and its fractions. Indones J
Pharm 17:136–142
Russo M, Spagnuolo C, Tedesco I, Russo GL (2010) Phytochemicals in cancer prevention and
therapy: truth or dare? Toxins 2:517–551
Sharma K, Le N, Alotaibi M, Gewirtz DA (2014) Cytotoxic autophagy in cancer therapy. Int J Mol
Sci 15:10034–10051
Slaby O, Sachlova M, Brezkova V, Hezova R, Kovarikova A, Bischofová S, Sevcikova S,
Bienertova-Vasku J, Vasku A, Svoboda M (2013) Identification of microRNAs regulated by
isothiocyanates and association of polymorphisms inside their target sites with risk of sporadic
colorectal cancer. Nutr Cancer 65:247–254
Sonoki H, Sato T, Endo S, Matsunaga T, Yamaguchi M, Yamazaki Y, Sugatani J, Ikari A (2015)
Quercetin decreases claudin-2 expression mediated by up-regulation of microRNA miR-16 in
lung adenocarcinoma A549 cells. Nutrients 7:4578–4592
Spagnuolo C, Russo GL, Orhan IE, Habtemariam S, Daglia M, Sureda A, Nabavi SF, Devi KP,
Loizzo MR, Tundis R, Nabavi SM (2015) Genistein and cancer: current status, challenges, and
future directions. Adv Nutr 6:408–419
Srinivas US, Tan BW, Vellayappan BA, Jeyasekharan AD (2019) ROS and the DNA damage
response in cancer. Redox Biol 25:101084
Takada Y, Andreeff M, Aggarwal BB (2005) Indole-3-carbinol suppresses NF-kB and IkBa kinase
activation, causing inhibition of expression of NF-kB-regulated antiapoptotic and metastatic
gene products and enhancement of apoptosis in myeloid and leukemia cells. Blood 106:641–
649
148
B. Cilwyn et al.