Guo L-m, Ding G-f, Xu W, Ge H, Jiang Y, Chen X-j, Lu Y (2018) MiR-135a-5p represses
proliferation of HNSCC by targeting HOXA10. Cancer Biol Ther 19:973–983
Gupta SC, Patchva S, Aggarwal BB (2013) Therapeutic roles of curcumin: lessons learned from
clinical trials. AAPS J 15:195–218
Halliwell B (2008) Are polyphenols antioxidants or pro-oxidants? What do we learn from cell
culture and in vivo studies? Arch Biochem Biophys 476:107–112
Hargraves KG, He L, Firestone GL (2016) Phytochemical regulation of the tumor suppressive
microRNA, miR-34a, by p53-dependent and independent responses in human breast cancer
cells. Mol Carcinog 55:486–498
He L, He X, Lim LP, De Stanchina E, Xuan Z, Liang Y, Xue W, Zender L, Magnus J, Ridzon D
(2007) A microRNA component of the p53 tumour suppressor network. Nature 447:1130–
1134
Hengartner MO (2000) The biochemistry of apoptosis. Nature 407:770–776
Hermeking H (2010) The miR-34 family in cancer and apoptosis. Cell Death Differ 17:193–199
Hostanska K, Reichling J, Bommer S, Weber M, Saller R (2003) Hyperforin a constituent of St
John’s wort (Hypericum perforatum L.) extract induces apoptosis by triggering activation of
caspases and with hypericin synergistically exerts cytotoxicity towards human malignant cell
lines. Eur J Pharm Biopharm 56:121–132
Huang L, Li B-L, He C-X, Zhao Y-J, Yang X-L, Pang B, Zhang X-H, Shan Y-J (2018)
Sulforaphane inhibits human bladder cancer cell invasion by reversing epithelial-tomesenchymal transition via directly targeting microRNA-200c/ZEB1 axis. J Funct Foods
41:118–126
Jin J, Lin G, Huang H, Xu D, Yu H, Ma X, Zhu L, Ma D, Jiang H (2014) Capsaicin mediates cell
cycle arrest and apoptosis in human colon cancer cells via stabilizing and activating p53. Int J
Biol Sci 10:285
Kim M-K, Kim K, Han JY, Lim JM, Song YS (2011) Modulation of inflammatory signaling
pathways by phytochemicals in ovarian cancer. Genes Nutr 6:109–115
Kruk J, Aboul-Enein HY, Kładna A, Bowser JE (2019) Oxidative stress in biological systems and
its relation with pathophysiological functions: the effect of physical activity on cellular redox
homeostasis. Free Radic Res 53:497–521
Kueck A, Opipari AW Jr, Griffith KA, Tan L, Choi M, Huang J, Wahl H, Liu JR (2007)
Resveratrol inhibits glucose metabolism in human ovarian cancer cells. Gynecol Oncol
107:450–457
Kumar A, Rimando AM, Levenson AS (2017) Resveratrol and pterostilbene as a
microRNA-mediated chemopreventive and therapeutic strategy in prostate cancer. Ann N Y
Acad Sci 1403:15–26
Kumar M, Kaur V, Kumar S, Kaur S (2016) Phytoconstituents as apoptosis inducing agents:
strategy to combat cancer. Cytotechnology 68:531–563
Lalaoui N, Brumatti G (2017) Relevance of necroptosis in cancer. Immunol Cell Biol 95:137–145
Lee HS, Cho HJ, Yu R, Lee KW, Chun HS, Park JHY (2014) Mechanisms underlying
apoptosis-inducing effects of Kaempferol in HT-29 human colon cancer cells. Int J Mol Sci
15:2722–2737
Lee J-C, Won S-J, Chao C-L, Wu F-L, Liu H-S, Ling P, Lin C-N, Su C-L (2008) Morusin induces
apoptosis and suppresses NF-jB activity in human colorectal cancer HT-29 cells. Biochem
Biophys Res Commun 372:236–242
Lee S, Clark R (2016) Anti-tumorigenic effects of capsaicin in colon cancer. J Food Chem
Nanotechnol 2:162–167
Lee SY, Ju MK, Jeon HM, Jeong EK, Lee YJ, Kim CH, Park HG, Han SI, Kang HS (2018)
Regulation of tumor progression by programmed necrosis. Oxidative Med Cell Longev
2018:3537471
Lewinska A, Adamczyk-Grochala J, Deregowska A, Wnuk M (2017) Sulforaphane-induced cell
cycle arrest and senescence are accompanied by DNA hypomethylation and changes in
microRNA profile in breast cancer cells. Theranostics 7:3461
146
B. Cilwyn et al.
proliferation of HNSCC by targeting HOXA10. Cancer Biol Ther 19:973–983
Gupta SC, Patchva S, Aggarwal BB (2013) Therapeutic roles of curcumin: lessons learned from
clinical trials. AAPS J 15:195–218
Halliwell B (2008) Are polyphenols antioxidants or pro-oxidants? What do we learn from cell
culture and in vivo studies? Arch Biochem Biophys 476:107–112
Hargraves KG, He L, Firestone GL (2016) Phytochemical regulation of the tumor suppressive
microRNA, miR-34a, by p53-dependent and independent responses in human breast cancer
cells. Mol Carcinog 55:486–498
He L, He X, Lim LP, De Stanchina E, Xuan Z, Liang Y, Xue W, Zender L, Magnus J, Ridzon D
(2007) A microRNA component of the p53 tumour suppressor network. Nature 447:1130–
1134
Hengartner MO (2000) The biochemistry of apoptosis. Nature 407:770–776
Hermeking H (2010) The miR-34 family in cancer and apoptosis. Cell Death Differ 17:193–199
Hostanska K, Reichling J, Bommer S, Weber M, Saller R (2003) Hyperforin a constituent of St
John’s wort (Hypericum perforatum L.) extract induces apoptosis by triggering activation of
caspases and with hypericin synergistically exerts cytotoxicity towards human malignant cell
lines. Eur J Pharm Biopharm 56:121–132
Huang L, Li B-L, He C-X, Zhao Y-J, Yang X-L, Pang B, Zhang X-H, Shan Y-J (2018)
Sulforaphane inhibits human bladder cancer cell invasion by reversing epithelial-tomesenchymal transition via directly targeting microRNA-200c/ZEB1 axis. J Funct Foods
41:118–126
Jin J, Lin G, Huang H, Xu D, Yu H, Ma X, Zhu L, Ma D, Jiang H (2014) Capsaicin mediates cell
cycle arrest and apoptosis in human colon cancer cells via stabilizing and activating p53. Int J
Biol Sci 10:285
Kim M-K, Kim K, Han JY, Lim JM, Song YS (2011) Modulation of inflammatory signaling
pathways by phytochemicals in ovarian cancer. Genes Nutr 6:109–115
Kruk J, Aboul-Enein HY, Kładna A, Bowser JE (2019) Oxidative stress in biological systems and
its relation with pathophysiological functions: the effect of physical activity on cellular redox
homeostasis. Free Radic Res 53:497–521
Kueck A, Opipari AW Jr, Griffith KA, Tan L, Choi M, Huang J, Wahl H, Liu JR (2007)
Resveratrol inhibits glucose metabolism in human ovarian cancer cells. Gynecol Oncol
107:450–457
Kumar A, Rimando AM, Levenson AS (2017) Resveratrol and pterostilbene as a
microRNA-mediated chemopreventive and therapeutic strategy in prostate cancer. Ann N Y
Acad Sci 1403:15–26
Kumar M, Kaur V, Kumar S, Kaur S (2016) Phytoconstituents as apoptosis inducing agents:
strategy to combat cancer. Cytotechnology 68:531–563
Lalaoui N, Brumatti G (2017) Relevance of necroptosis in cancer. Immunol Cell Biol 95:137–145
Lee HS, Cho HJ, Yu R, Lee KW, Chun HS, Park JHY (2014) Mechanisms underlying
apoptosis-inducing effects of Kaempferol in HT-29 human colon cancer cells. Int J Mol Sci
15:2722–2737
Lee J-C, Won S-J, Chao C-L, Wu F-L, Liu H-S, Ling P, Lin C-N, Su C-L (2008) Morusin induces
apoptosis and suppresses NF-jB activity in human colorectal cancer HT-29 cells. Biochem
Biophys Res Commun 372:236–242
Lee S, Clark R (2016) Anti-tumorigenic effects of capsaicin in colon cancer. J Food Chem
Nanotechnol 2:162–167
Lee SY, Ju MK, Jeon HM, Jeong EK, Lee YJ, Kim CH, Park HG, Han SI, Kang HS (2018)
Regulation of tumor progression by programmed necrosis. Oxidative Med Cell Longev
2018:3537471
Lewinska A, Adamczyk-Grochala J, Deregowska A, Wnuk M (2017) Sulforaphane-induced cell
cycle arrest and senescence are accompanied by DNA hypomethylation and changes in
microRNA profile in breast cancer cells. Theranostics 7:3461
146
B. Cilwyn et al.