92
produces either eremophilan-8-ones or furanoeremophilanes, so two chemotypes
are known. Moreover, aromatics and other types of terpenoids are also produced.
3.7 Ligularia intermedia Nakai
Several aromatic compounds (913, 952, 953, 956, 957, and 989) and hydroperoxides (991 and 992), along with five triterpenoids (828, 834, 835, 840, and 841), were
isolated from L. intermedia by Jia’s group (sample 1, Table 10) [250, 260]. Another
sample of this species (sample 2) from Hubei Province, China, was found to produce 10H-furanoeremophilanes, inclusive of the 15,6-lactones 212 (major constituent) and eremofarfugins B4 (522), G (544), and F (545), and two other eremophilanes
(328 and 511), as well as bakkenolide A (629) [140]. The original structure of a
7α,8α-epoxide of compound 522 was later revised as a 7β,8β-epoxide, as depicted
Fig. 23 10H-Eremophilan-12,8-olides (3)
M. Tori and C. Kuroda
produces either eremophilan-8-ones or furanoeremophilanes, so two chemotypes
are known. Moreover, aromatics and other types of terpenoids are also produced.
3.7 Ligularia intermedia Nakai
Several aromatic compounds (913, 952, 953, 956, 957, and 989) and hydroperoxides (991 and 992), along with five triterpenoids (828, 834, 835, 840, and 841), were
isolated from L. intermedia by Jia’s group (sample 1, Table 10) [250, 260]. Another
sample of this species (sample 2) from Hubei Province, China, was found to produce 10H-furanoeremophilanes, inclusive of the 15,6-lactones 212 (major constituent) and eremofarfugins B4 (522), G (544), and F (545), and two other eremophilanes
(328 and 511), as well as bakkenolide A (629) [140]. The original structure of a
7α,8α-epoxide of compound 522 was later revised as a 7β,8β-epoxide, as depicted
Fig. 23 10H-Eremophilan-12,8-olides (3)
M. Tori and C. Kuroda