107
Fig. 34 Cacalolide derivatives and other lactones
1. This species is of considerable interest, so additional samples should be analyzed
in the future.
3.11 Ligularia lapathifolia (Franchet) Handel-Mazzetti
Sample 1 of L. lapathifolia produced two 3β-angeloyloxynoreremophilan-15-oic
acids, 116 and 144 (Table 14), with the structure of 144 being determined by X-ray
crystallographic analysis [92]. In the case of sample 2, six 10H-3βangeloyloxyeremophilanes (224, 504, 506, 507, 508, and 515) and the 10-OH eremophilanolide 514 were afforded [148]. All these compounds bear a 15,6-lactone
moiety. A symmetrical dimer (581) was isolated from sample 3 [213]. Sample 4
from Sichuan Province, China, furnished six 15-oxidized compounds: the normethyl ester 134, the simple dimethyl ester 79 (as a major constituent), three
15,6-lactones (499, 501, and 502), and the 15-methyl ester 355 [81]. The structure
Chemical Constituents of Ligularia Species (Asteraceae) and Their Diversity…
Fig. 34 Cacalolide derivatives and other lactones
1. This species is of considerable interest, so additional samples should be analyzed
in the future.
3.11 Ligularia lapathifolia (Franchet) Handel-Mazzetti
Sample 1 of L. lapathifolia produced two 3β-angeloyloxynoreremophilan-15-oic
acids, 116 and 144 (Table 14), with the structure of 144 being determined by X-ray
crystallographic analysis [92]. In the case of sample 2, six 10H-3βangeloyloxyeremophilanes (224, 504, 506, 507, 508, and 515) and the 10-OH eremophilanolide 514 were afforded [148]. All these compounds bear a 15,6-lactone
moiety. A symmetrical dimer (581) was isolated from sample 3 [213]. Sample 4
from Sichuan Province, China, furnished six 15-oxidized compounds: the normethyl ester 134, the simple dimethyl ester 79 (as a major constituent), three
15,6-lactones (499, 501, and 502), and the 15-methyl ester 355 [81]. The structure
Chemical Constituents of Ligularia Species (Asteraceae) and Their Diversity…