96
Sample 6 produced four 10H-eremophilanes (196, 212, 491, and 492) and three
p-menthane monoterpenoids (869, 872, and 873) [132, 133]. Three noreremophilanes (118, 123, and 125), petasin (54), isopetasin (56), two dilactones (491
and 493), and two triterpenoids (828 and 830) were isolated from sample 7 (Shanxi
Province, China) [77, 204]. Sample 8 produced the noreremophilane 141 and the
10-OH eremophilanolide 389 [111]. Compound 141 exhibits a double bond between
C-7 and C-9 (Fig. 8), which is the first such example for a norbakkane type compound, since normally these have a double bond between C-6 and C-7.
3.8 Ligularia vellerea (Franchet) Handel-Mazzetti
Two lactones (344 and 357) as well as umbelliferone (916) and 4- hydroxyacetophenone (906) were isolated from sample 1 of L. vellerea (Yunnan Province, China)
(Table 11, Plate 9) [149]. Three L. vellerea samples (samples 3, 4, and 8) were
found to produce the bicyclic eremophilanes eremophila-1(10),11-diene (1) and
fukinone (4), and the norketone 132 [26]. Typical compounds occurring in this species are 15-oic acids, such as 199, 542, and 543. An acid (199), a methyl ester (200),
and a 15,6-ether derivative (211) were isolated from sample 5 [26]. Compound 212
Fig. 26 10-OH-3-Acetoxyeremophilan-12,8-olides
M. Tori and C. Kuroda
Sample 6 produced four 10H-eremophilanes (196, 212, 491, and 492) and three
p-menthane monoterpenoids (869, 872, and 873) [132, 133]. Three noreremophilanes (118, 123, and 125), petasin (54), isopetasin (56), two dilactones (491
and 493), and two triterpenoids (828 and 830) were isolated from sample 7 (Shanxi
Province, China) [77, 204]. Sample 8 produced the noreremophilane 141 and the
10-OH eremophilanolide 389 [111]. Compound 141 exhibits a double bond between
C-7 and C-9 (Fig. 8), which is the first such example for a norbakkane type compound, since normally these have a double bond between C-6 and C-7.
3.8 Ligularia vellerea (Franchet) Handel-Mazzetti
Two lactones (344 and 357) as well as umbelliferone (916) and 4- hydroxyacetophenone (906) were isolated from sample 1 of L. vellerea (Yunnan Province, China)
(Table 11, Plate 9) [149]. Three L. vellerea samples (samples 3, 4, and 8) were
found to produce the bicyclic eremophilanes eremophila-1(10),11-diene (1) and
fukinone (4), and the norketone 132 [26]. Typical compounds occurring in this species are 15-oic acids, such as 199, 542, and 543. An acid (199), a methyl ester (200),
and a 15,6-ether derivative (211) were isolated from sample 5 [26]. Compound 212
Fig. 26 10-OH-3-Acetoxyeremophilan-12,8-olides
M. Tori and C. Kuroda