186
8 Ulvans
with sulfated polysaccharides. In addition to the general sulfated polysaccharide
bioactivities, ulvans are particularly promising as immunomodulatory, antioxidant
and antihyperlipidemic agents. Much of the studies on ulvans bioactive properties
are at an early stage using cellular and animal test models. It is nonetheless important
to understand the potential application and the state of technology in the respective
applications. Such will be useful in advising further efforts in the use of ulvans.
References
Adrien A, Bonnet A, Dufour D, Baudouin S, Maugard T, Bridiau N (2017) Pilot production of
ulvans from Ulva sp. and their effects on hyaluronan and collagen production in cultured dermal
fibroblasts. Carbohyd Polym 157:1306–1314
Aguilar-Briseno JA, Cruz-Suarez LE, Sassi JF, Ricque-Marie D, Zapata-Benavides P, Gamboa EM,
Rodriguez-Padilla C, Trejo-Avila LM (2015) Sulphated polysaccharides from ulva clathrata and
cladosiphon okamuranus Seaweeds both inhibit viral attachment/entry and cell-cell fusion, in
NDV Infection. Marine Drugs 13(2):697–712
Ali MM, Agha FG (2009) Amelioration of streptozotocin-induced diabetes mellitus, oxidative stress
and dyslipidemia in rats by tomato extract lycopene. Scand J Clin Lab Inv 69:371–379
Berri M, Slugocki C, Olivier M, Helloin E, Jacques I, Salmon H, Demais H, Le Goff M, Nyvall P,
Collen (2016) Marine-sulfated polysaccharides extract of Ulva armoricana green algae exhibits
an antimicrobial activity and stimulates cytokine expression by intestinal epithelial cells. J Appl
Phycol 28:2999–3008
Berri M, Olivier M, Holbert S, Dupont J, Demais H, Le Goff M, Nyvall Collen P (2017) Ulvan from
Ulva armoricana (Chlorophyta) activates the P13K/Akt signalling pathway via TLR4 to induce
intestinal cytokine production. Algal Res 28:39–47
Bird RB, Stewart WE, Lightfoot EN (2005) Transport phenomena, 2nd edn. Wiley-India, New
Delhi, pp 270
Castro R, Piazzon MC, Zarra I, Leiro J, Noya M, Lamas J (2006) Stimulation of turbot phagocytes
by ulva rigida C. agardh polysaccharides. Aquaculture 254:9–20
Chen D, Wu XZ, Wen ZY (2008) Sulphated polysaccharides and immune response: promoters or
inhibitors. Panminerva Med 50:177–183
Cho M, Yang C, Kim SM, You S (2010) Molecular characterization and biological activities of watersoluble sulfated polysaccharides from Enteromorpha prolifera. Food Sci Biotechnol 19:525–533
Fernández-Díaz C, Coste O, Malta EJ (2017) Polymer chitosan nanoparticles functionalized
with Ulva ohnoi extracts boost in vitro ulvan immunostimulant effect in Solea senegalensis
macrophages. Algal Res 26:135–142
Glasson CRK, Sims IM, Carnachan SM, de Nys R, Magnusson M (2017) A cascading biorefinery
process targeting sulfated polysaccharides (ulvan) from Ulva ohnoi. Algal Res 27:383–391
Hussein UK, Mahmoud HM, Farrag AG, Bishayee A (2015) Chemoprevention of
diethylnitrosamine-initiated and phenobarbital-promoted hepatocarcinogenesis in rats by sulfated
polysaccharides and aqueous extract of Ulva lactuca. Integr Cancer Ther 14:525–545
Jaswir I, Monsur HA (2011) Anti-inflammatory compounds of macro algae origin: a review. J Med
Plant Res 5:7146–7154
Jiao LL, Li X, Li TB, Jiang P, Zhang LX, Wu MJ, Zhang LP (2009) Characterization and anti-tumor
activity of alkali-extracted polysaccharide from Enteromorpha intestinalis. Int Immunopharmacol
9(3):324–329
Karnjanaprakorn S, Tabarsa M, Chou M, You SG (2012) Characterization and immunomodulatory
activities of sulfated polysaccharides from Capsosiphon fulvescens. Int J Biol Macromol 51:720–
729
8 Ulvans
with sulfated polysaccharides. In addition to the general sulfated polysaccharide
bioactivities, ulvans are particularly promising as immunomodulatory, antioxidant
and antihyperlipidemic agents. Much of the studies on ulvans bioactive properties
are at an early stage using cellular and animal test models. It is nonetheless important
to understand the potential application and the state of technology in the respective
applications. Such will be useful in advising further efforts in the use of ulvans.
References
Adrien A, Bonnet A, Dufour D, Baudouin S, Maugard T, Bridiau N (2017) Pilot production of
ulvans from Ulva sp. and their effects on hyaluronan and collagen production in cultured dermal
fibroblasts. Carbohyd Polym 157:1306–1314
Aguilar-Briseno JA, Cruz-Suarez LE, Sassi JF, Ricque-Marie D, Zapata-Benavides P, Gamboa EM,
Rodriguez-Padilla C, Trejo-Avila LM (2015) Sulphated polysaccharides from ulva clathrata and
cladosiphon okamuranus Seaweeds both inhibit viral attachment/entry and cell-cell fusion, in
NDV Infection. Marine Drugs 13(2):697–712
Ali MM, Agha FG (2009) Amelioration of streptozotocin-induced diabetes mellitus, oxidative stress
and dyslipidemia in rats by tomato extract lycopene. Scand J Clin Lab Inv 69:371–379
Berri M, Slugocki C, Olivier M, Helloin E, Jacques I, Salmon H, Demais H, Le Goff M, Nyvall P,
Collen (2016) Marine-sulfated polysaccharides extract of Ulva armoricana green algae exhibits
an antimicrobial activity and stimulates cytokine expression by intestinal epithelial cells. J Appl
Phycol 28:2999–3008
Berri M, Olivier M, Holbert S, Dupont J, Demais H, Le Goff M, Nyvall Collen P (2017) Ulvan from
Ulva armoricana (Chlorophyta) activates the P13K/Akt signalling pathway via TLR4 to induce
intestinal cytokine production. Algal Res 28:39–47
Bird RB, Stewart WE, Lightfoot EN (2005) Transport phenomena, 2nd edn. Wiley-India, New
Delhi, pp 270
Castro R, Piazzon MC, Zarra I, Leiro J, Noya M, Lamas J (2006) Stimulation of turbot phagocytes
by ulva rigida C. agardh polysaccharides. Aquaculture 254:9–20
Chen D, Wu XZ, Wen ZY (2008) Sulphated polysaccharides and immune response: promoters or
inhibitors. Panminerva Med 50:177–183
Cho M, Yang C, Kim SM, You S (2010) Molecular characterization and biological activities of watersoluble sulfated polysaccharides from Enteromorpha prolifera. Food Sci Biotechnol 19:525–533
Fernández-Díaz C, Coste O, Malta EJ (2017) Polymer chitosan nanoparticles functionalized
with Ulva ohnoi extracts boost in vitro ulvan immunostimulant effect in Solea senegalensis
macrophages. Algal Res 26:135–142
Glasson CRK, Sims IM, Carnachan SM, de Nys R, Magnusson M (2017) A cascading biorefinery
process targeting sulfated polysaccharides (ulvan) from Ulva ohnoi. Algal Res 27:383–391
Hussein UK, Mahmoud HM, Farrag AG, Bishayee A (2015) Chemoprevention of
diethylnitrosamine-initiated and phenobarbital-promoted hepatocarcinogenesis in rats by sulfated
polysaccharides and aqueous extract of Ulva lactuca. Integr Cancer Ther 14:525–545
Jaswir I, Monsur HA (2011) Anti-inflammatory compounds of macro algae origin: a review. J Med
Plant Res 5:7146–7154
Jiao LL, Li X, Li TB, Jiang P, Zhang LX, Wu MJ, Zhang LP (2009) Characterization and anti-tumor
activity of alkali-extracted polysaccharide from Enteromorpha intestinalis. Int Immunopharmacol
9(3):324–329
Karnjanaprakorn S, Tabarsa M, Chou M, You SG (2012) Characterization and immunomodulatory
activities of sulfated polysaccharides from Capsosiphon fulvescens. Int J Biol Macromol 51:720–
729