118
5 Fucoidan
Kuznetsova TA, Besednova NN, Somova LM, Plekhova NG (2014) Fucoidan extracted from Fucus
evanescens prevents endotoxin-induced damage in a mouse model of endotoxemia. Marine Drugs
12(2):886–898. https://doi.org/10.3390/md12020886
Kwak JY (2014) Fucoidan as a marine anticancer agent in preclinical development. Mar Drugs
12:851–870
Kylin H (1913) Zur Biochemie der meeresalgen. Z Für Physiol Chemie 83:171–197
Lahrsen E, Liewert I, Alban S (2018) Gradual degradation of fucoidan from fucus vesiculosus and
its effect on structures, antioxidant and antiproliferative activities. Carbohyd Polym 192:208–216
Lean QY, Eri RD, Fitton JH, Patel RP, Gueven N (2015) Fucoidan extracts ameliorate acute colitis.
PLoS ONE 10:e0128453
Lee JS, Jin GH, Yeo MG, Jang CH, Lee H, Kim GH (2012) Fabrication of electrospun biocomposites
comprising polycaprolactone/fucoidan for tissue regeneration. Carbohydr Polym 90:181–188
Lee KW, Jeong D, Na K (2013a) Doxorubicin loading fucoidan acetate nanoparticles for immune
and chemotherapy in cancer treatment. Carbohydr Polym 94:850–856
Lee KY, Jeong MR, Choi SM, Na SS, Cha JD (2013b) Synergistic effect of fucoidan with antibiotics
against oral pathogenic bacteria. Arch Oral Biol 58:482–492
Le Visage C, Chaubet DLF, Autissier A (2015) Method for preparing porous scaffold for tissue
engineering. U.S. Patent 9,028,857
Liu S, Wang Q, Song Y, He Y, Ren D, Cong H, Wu L (2018) Studies on the hepatoprotective effect
of fucoidan from brown algae Kjellmaniella crassifolia. Carbohyd Polym 193:298–306
Lu J, Shi KK, Chen S, Wang J, Hassouna A, White LN, Merien F, Xie M, Kong Q, Li J, Ying
T, White LW, Nie S (2018) Fucoidan extracted from the New Zealand Undaria pinnatifidaphysicochemical comparison against five other fucoidans: unique low molecular weight fraction
bioactivity in breast cancer cell lines. Mar Drugs 16(461):1–25
Manne BK, Getz TM, Hughes CE, Alshehri O, Dangelmaier C, Naik UP, Watson SP, Kunapuli SP
(2013) Fucoidan is a novel platelet agonist for the c-type lectin-like receptor 2 (clec-2). J Biol
Chem 288:7717–7726
Matsubara K, Xue C, Zhao X, Mori M, Sugawara T, Hirata T (2005) Effects of middle molecular
weight fucoidans on in vitro and ex vivo angiogenesis of endothelial cells. Int J Mol Med 15:695–
699
Michel C, Lahaye M, Bonnet C, Mabeau S, Barry JL (1996) In vitro fermentation by human faecal
bacteria of total and purified dietary fibres from brown seaweeds. Br J Nutr 75:263–280
Min SK, Kwon OC, Lee S, Park KH, Kim JK (2011) An antithrombotic fucoidan, unlike heparin,
does not prolong bleeding time in a murine arterial thrombosis model: a comparative study of
Undaria pinnatifida sporophylls and Fucus vesiculosus. Phytother Res 26:752–757
Miyazaki Y, Iwaihara Y, Nakamizo M, Takeuchi S, Takeuchi H, Tachikawa D (2018) Potentiating
effects of high-molecular weight fucoidan-agaricus mix (CUA) feeding on tumor vaccination. J
Immunol 200(181):22–34
Monagail MM, Cornish L, Morrison L, Araujo R, Critchley AT (2017) Sustainable harvesting of
wild seaweed resources. Eur J Phycol 52(4):371–390
Mori N1, Nakasone K, Tomimori K, Ishikawa C (2012) Beneficial effects of fucoidan in patients
with chronic hepatitis C virus infection. World J Gastroenterol 18(18):2225–2230. https://doi.
org/10.3748/wjg.v18.i18.2225
Nagao T, Kumabe A, Komatsu F, Yagi H, Suzuki H, Ohshiro T (2017) Gene identification and
characterization of fucoidan deacetylase for potential application to fucoidan degradation and
diversification. J Biosci Bioeng 124(3):277–282
Nambisan P (1999) Seaweed biotechnology. Cyanobacterial and algal metabolism and environmental biotechnology, 236–246
Negishi H, Mori M, Mori H, Yamori Y (2013) Supplementation of elderly Japanese men and women
with fucoidan from seaweed increases immune responses to seasonal influenza vaccination. J Nutr
143:1794–1798
5 Fucoidan
Kuznetsova TA, Besednova NN, Somova LM, Plekhova NG (2014) Fucoidan extracted from Fucus
evanescens prevents endotoxin-induced damage in a mouse model of endotoxemia. Marine Drugs
12(2):886–898. https://doi.org/10.3390/md12020886
Kwak JY (2014) Fucoidan as a marine anticancer agent in preclinical development. Mar Drugs
12:851–870
Kylin H (1913) Zur Biochemie der meeresalgen. Z Für Physiol Chemie 83:171–197
Lahrsen E, Liewert I, Alban S (2018) Gradual degradation of fucoidan from fucus vesiculosus and
its effect on structures, antioxidant and antiproliferative activities. Carbohyd Polym 192:208–216
Lean QY, Eri RD, Fitton JH, Patel RP, Gueven N (2015) Fucoidan extracts ameliorate acute colitis.
PLoS ONE 10:e0128453
Lee JS, Jin GH, Yeo MG, Jang CH, Lee H, Kim GH (2012) Fabrication of electrospun biocomposites
comprising polycaprolactone/fucoidan for tissue regeneration. Carbohydr Polym 90:181–188
Lee KW, Jeong D, Na K (2013a) Doxorubicin loading fucoidan acetate nanoparticles for immune
and chemotherapy in cancer treatment. Carbohydr Polym 94:850–856
Lee KY, Jeong MR, Choi SM, Na SS, Cha JD (2013b) Synergistic effect of fucoidan with antibiotics
against oral pathogenic bacteria. Arch Oral Biol 58:482–492
Le Visage C, Chaubet DLF, Autissier A (2015) Method for preparing porous scaffold for tissue
engineering. U.S. Patent 9,028,857
Liu S, Wang Q, Song Y, He Y, Ren D, Cong H, Wu L (2018) Studies on the hepatoprotective effect
of fucoidan from brown algae Kjellmaniella crassifolia. Carbohyd Polym 193:298–306
Lu J, Shi KK, Chen S, Wang J, Hassouna A, White LN, Merien F, Xie M, Kong Q, Li J, Ying
T, White LW, Nie S (2018) Fucoidan extracted from the New Zealand Undaria pinnatifidaphysicochemical comparison against five other fucoidans: unique low molecular weight fraction
bioactivity in breast cancer cell lines. Mar Drugs 16(461):1–25
Manne BK, Getz TM, Hughes CE, Alshehri O, Dangelmaier C, Naik UP, Watson SP, Kunapuli SP
(2013) Fucoidan is a novel platelet agonist for the c-type lectin-like receptor 2 (clec-2). J Biol
Chem 288:7717–7726
Matsubara K, Xue C, Zhao X, Mori M, Sugawara T, Hirata T (2005) Effects of middle molecular
weight fucoidans on in vitro and ex vivo angiogenesis of endothelial cells. Int J Mol Med 15:695–
699
Michel C, Lahaye M, Bonnet C, Mabeau S, Barry JL (1996) In vitro fermentation by human faecal
bacteria of total and purified dietary fibres from brown seaweeds. Br J Nutr 75:263–280
Min SK, Kwon OC, Lee S, Park KH, Kim JK (2011) An antithrombotic fucoidan, unlike heparin,
does not prolong bleeding time in a murine arterial thrombosis model: a comparative study of
Undaria pinnatifida sporophylls and Fucus vesiculosus. Phytother Res 26:752–757
Miyazaki Y, Iwaihara Y, Nakamizo M, Takeuchi S, Takeuchi H, Tachikawa D (2018) Potentiating
effects of high-molecular weight fucoidan-agaricus mix (CUA) feeding on tumor vaccination. J
Immunol 200(181):22–34
Monagail MM, Cornish L, Morrison L, Araujo R, Critchley AT (2017) Sustainable harvesting of
wild seaweed resources. Eur J Phycol 52(4):371–390
Mori N1, Nakasone K, Tomimori K, Ishikawa C (2012) Beneficial effects of fucoidan in patients
with chronic hepatitis C virus infection. World J Gastroenterol 18(18):2225–2230. https://doi.
org/10.3748/wjg.v18.i18.2225
Nagao T, Kumabe A, Komatsu F, Yagi H, Suzuki H, Ohshiro T (2017) Gene identification and
characterization of fucoidan deacetylase for potential application to fucoidan degradation and
diversification. J Biosci Bioeng 124(3):277–282
Nambisan P (1999) Seaweed biotechnology. Cyanobacterial and algal metabolism and environmental biotechnology, 236–246
Negishi H, Mori M, Mori H, Yamori Y (2013) Supplementation of elderly Japanese men and women
with fucoidan from seaweed increases immune responses to seasonal influenza vaccination. J Nutr
143:1794–1798