116
5 Fucoidan
Alvarez-Vinas M, Florez-Fernandez N, Gonzalez-Munoz JM, Dominguez H (2019) Influence of
molecular weight on the properties of Sargassum muticum fucoidan. Algal Res 38 (Article101393)
Azuma K, Ishihara T, Nakamoto H, Amaha T, Osaki T, Tsuka T, Imagawa T, Minami S, Takashima
O, Ifuku S et al (2012) Effects of oral administration of fucoidan extracted from Cladosiphon
okamuranus on tumor growth and survival time in a tumor-bearing mouse model. Mar Drugs
10:2337–2348
Berteau O, Mulloy B (2003) Sulfated fucans, fresh perspectives: structures, functions, and biological properties of sulfated fucans and an overview of enzymes active toward this class of
polysaccharides. Glycobiology 13:29–40
Bilan MI, Kusaykin MI, Grachev AA, Tsvetkova EA, Zvyagintseva TN, Nifantiev NE, Usov AI
(2005) Effect of enzyme preparation from the marine mollusk Littorina kurila on fucoidan from
the brown alga Fucus distichus. Biochemistry (Moscow) 70:1321–1326
Carvalho AC, Sousa RB, Franco AX, Costa JV, Neves LM, Ribeiro RA, Sutton R, Criddle DN,
Soares PM, de Souza MH (2014) Protective effects of fucoidan, a p- and l-selectin inhibitor, in
murine acute pancreatitis. Pancreas 43:82–87
Chang Y (2010) Isolation and characterization of sea cucumber fucoidan utilizing marine bacterium.
Lett Appl Microbiol 50(3):301–307
Chang Y, Hu Y, Yu L, McClements DJ, Xu X, Liu G, Xue C (2015) Primary structure and chain
conformation of fucoidan extracted from sea cucumber Holothuria tubulosa. Carbohyd Polym.
https://doi.org/10.1016/j.carbpol.2015.10.016
Chen S, Zhao Y, Zhang Y, Zhang D (2014) Fucoidan induces cancer cell apoptosis by modulating
the endoplasmic reticulum stress cascades. PLoS ONE 9:e108157
Chen YM, Tsai YH, Tsai TY, Chiu YS, Wei L, Chen WC, Huang CC (2015) Fucoidan supplementation improves exercise performance and exhibits anti-fatigue action in mice. Nutrients
7:239–252
Cho ML, Lee BY, You S (2011) Relationship between oversulfation and conformation of low and
high molecular weight fucoidans and evaluation of their in vitro anticancer activity. Molecules
16:291–297
Cumashi A, Ushakova NA, Preobrazhenskaya ME, D’Incecco A, Piccoli A, Totani L, Tinari N,
Morozevich GE, Berman AE, Bilan MI (2007) A comparative study of the anti-inflammatory,
anticoagulant, antiangiogenic, and antiadhesive activities of nine different fucoidans from brown
seaweeds. Glycobiology 17:541–552
Deniaud-Bouët E, Hardouin K, Potin P, Kloareg B, Hervé C (2017) A review about brown algal cell
walls and fucose-containing sulfated polysaccharides: cell wall context, biomedical properties
and key research challenges. Carbohyd Polym 175:395–408. https://doi.org/10.1016/j.carbpol.
2017.07.082
Dockal M, Ehrlich H, Scheiflinger F (2014) Methods and compositions for treating bleeding
disorders. U.S. Patent 8,632,991
Dürig J, Bruhn T, Zurborn K-H, Gutensohn K, Bruhn HD, Béress L (1997) Anticoagulant fucoidan
fractions from Fucus vesiculosus induce platelet activation in vitro. Thromb Res 85:479–491
Elizondo-Gonzalez R, Cruz-Suarez LE, Ricque-Marie D, Mendoza-Gamboa E, Rodriguez-Padilla
C, Trejo-Avila LM (2012) In vitro characterization of the antiviral activity of fucoidan from
Cladosiphon okamuranus against newcastle disease virus. Virol J 9:307. https://doi.org/10.1186/
1743-422X-9-307
Esmaeelian B, Abbott CA, Le Leu RK, Benkendorff K (2014) 6-bromoisatin found in muricid
mollusc extracts inhibits colon cancer cell proliferation and induces apoptosis, preventing early
stage tumor formation in a colorectal cancer rodent model. Mar Drugs 12:17–35
Fitton J (2011) Therapies from fucoidan; multifunctional marine polymers. Mar Drugs 9:1731–1760
Fitton JH, Dell’Acqua G, Gardiner VA, Karpiniec SS, Stringer DN, Davis E (2015a) Topical benefits
of two fucoidan-rich extracts from marine macroalgae. Cosmetics 2:66–81
Fitton JH, Stringer DN, Karpiniec SS (2015b) Therapies from fucoidan: an update. Mar Drugs
13:5920–5946
5 Fucoidan
Alvarez-Vinas M, Florez-Fernandez N, Gonzalez-Munoz JM, Dominguez H (2019) Influence of
molecular weight on the properties of Sargassum muticum fucoidan. Algal Res 38 (Article101393)
Azuma K, Ishihara T, Nakamoto H, Amaha T, Osaki T, Tsuka T, Imagawa T, Minami S, Takashima
O, Ifuku S et al (2012) Effects of oral administration of fucoidan extracted from Cladosiphon
okamuranus on tumor growth and survival time in a tumor-bearing mouse model. Mar Drugs
10:2337–2348
Berteau O, Mulloy B (2003) Sulfated fucans, fresh perspectives: structures, functions, and biological properties of sulfated fucans and an overview of enzymes active toward this class of
polysaccharides. Glycobiology 13:29–40
Bilan MI, Kusaykin MI, Grachev AA, Tsvetkova EA, Zvyagintseva TN, Nifantiev NE, Usov AI
(2005) Effect of enzyme preparation from the marine mollusk Littorina kurila on fucoidan from
the brown alga Fucus distichus. Biochemistry (Moscow) 70:1321–1326
Carvalho AC, Sousa RB, Franco AX, Costa JV, Neves LM, Ribeiro RA, Sutton R, Criddle DN,
Soares PM, de Souza MH (2014) Protective effects of fucoidan, a p- and l-selectin inhibitor, in
murine acute pancreatitis. Pancreas 43:82–87
Chang Y (2010) Isolation and characterization of sea cucumber fucoidan utilizing marine bacterium.
Lett Appl Microbiol 50(3):301–307
Chang Y, Hu Y, Yu L, McClements DJ, Xu X, Liu G, Xue C (2015) Primary structure and chain
conformation of fucoidan extracted from sea cucumber Holothuria tubulosa. Carbohyd Polym.
https://doi.org/10.1016/j.carbpol.2015.10.016
Chen S, Zhao Y, Zhang Y, Zhang D (2014) Fucoidan induces cancer cell apoptosis by modulating
the endoplasmic reticulum stress cascades. PLoS ONE 9:e108157
Chen YM, Tsai YH, Tsai TY, Chiu YS, Wei L, Chen WC, Huang CC (2015) Fucoidan supplementation improves exercise performance and exhibits anti-fatigue action in mice. Nutrients
7:239–252
Cho ML, Lee BY, You S (2011) Relationship between oversulfation and conformation of low and
high molecular weight fucoidans and evaluation of their in vitro anticancer activity. Molecules
16:291–297
Cumashi A, Ushakova NA, Preobrazhenskaya ME, D’Incecco A, Piccoli A, Totani L, Tinari N,
Morozevich GE, Berman AE, Bilan MI (2007) A comparative study of the anti-inflammatory,
anticoagulant, antiangiogenic, and antiadhesive activities of nine different fucoidans from brown
seaweeds. Glycobiology 17:541–552
Deniaud-Bouët E, Hardouin K, Potin P, Kloareg B, Hervé C (2017) A review about brown algal cell
walls and fucose-containing sulfated polysaccharides: cell wall context, biomedical properties
and key research challenges. Carbohyd Polym 175:395–408. https://doi.org/10.1016/j.carbpol.
2017.07.082
Dockal M, Ehrlich H, Scheiflinger F (2014) Methods and compositions for treating bleeding
disorders. U.S. Patent 8,632,991
Dürig J, Bruhn T, Zurborn K-H, Gutensohn K, Bruhn HD, Béress L (1997) Anticoagulant fucoidan
fractions from Fucus vesiculosus induce platelet activation in vitro. Thromb Res 85:479–491
Elizondo-Gonzalez R, Cruz-Suarez LE, Ricque-Marie D, Mendoza-Gamboa E, Rodriguez-Padilla
C, Trejo-Avila LM (2012) In vitro characterization of the antiviral activity of fucoidan from
Cladosiphon okamuranus against newcastle disease virus. Virol J 9:307. https://doi.org/10.1186/
1743-422X-9-307
Esmaeelian B, Abbott CA, Le Leu RK, Benkendorff K (2014) 6-bromoisatin found in muricid
mollusc extracts inhibits colon cancer cell proliferation and induces apoptosis, preventing early
stage tumor formation in a colorectal cancer rodent model. Mar Drugs 12:17–35
Fitton J (2011) Therapies from fucoidan; multifunctional marine polymers. Mar Drugs 9:1731–1760
Fitton JH, Dell’Acqua G, Gardiner VA, Karpiniec SS, Stringer DN, Davis E (2015a) Topical benefits
of two fucoidan-rich extracts from marine macroalgae. Cosmetics 2:66–81
Fitton JH, Stringer DN, Karpiniec SS (2015b) Therapies from fucoidan: an update. Mar Drugs
13:5920–5946