485
(MCF-7) cell lines using the MTT assay. The maximum percentage of growth inhibition was 75.1 ± 7.78%, which was obtained at 6 mg/ml concentration.
22.4.5 Anti-diabetic Effect
After menopause, women’s glucose tolerance capacities deteriorate and accumulate
central fat. As a consequence of these menopausal changes, many menopausal
women have an experience in insulin resistance. Although some epidemiological
and clinical trial studies have reported that isoflavones has a beneficial effect on
insulin sensitivity and glucose metabolism, it is consistent in that isoflavones has
slight decreasing insulin resistance observed after menopause. Recent meta-analysis of randomized clinical trials supports the weak effect of isoflavones for diabetes
and shows no sufficient evidence in improving glycaemic condition (Ricci et al.
2010). Despite the limited evidences, fermented soy products may have better
effects in preventing the progression of type 2 diabetes relative to nonfermented soy
products (Kwon et al. 2010). In normoglycemic women, isoflavones is expected to
have an association with reduced insulin resistance. In summary, the effect of isoflavones as a treatment medicine for diabetes has no compelling evidences, however,
they seem to have a mild effect in preventing diabetes through reducing insulin
resistance.
22.4.6 Antiaging Effects of Isoflavones
Red clover extract which is rich in isoflavones mainly, formonetin and biochanin A
exerts a higher affinity for liposome formation in comparison to genistein and daidzein. Liposome-incorporated red clover extract resulted in a final product with significant antioxidant action as well as additional benefits in aging prevention (Klejdus
et al. 2001; Kanouni et al. 2002).
Soy isoflavones demonstrated UVB protective effects due to their antioxidant
activities (Chiang et al. 2007). In addition, soy isoflavone extract inhibited UVBinduced keratinocyte death and suppressed UVB-induced intracellular H 2 O 2 release,
decreased the epidermal thickness and inhibited COX-2 and proliferating cell
nuclear antigen (PCNA) expression. UVB-triggered activation of p38, c-Jun
N-terminal kinase (JNK) and extracellular signal regulated kinase (ERK1/2) which
were inhibited by treatment with a soy isoflavone extract (Chiang et al. 2007; Chiu
et al. 2009; Assefa et al. 2005).
Huang et al. (2010) evaluated the protective effects of soy isoflavone extract
fraction 3 from soybean cake that contains the aglycone group (daidzein, genistein
and glycitein) and acetylglucoside group (acetyldaidzin, acetylgenistin and acetylglycitin) on UVB-induced damage. The fraction inhibit UVB-induced death of
human keratinocytes and reduce the level of desquamation, transepidermal water
22 Health Benefits of Isoflavones Found Exclusively of Plants of the Fabaceae Family
(MCF-7) cell lines using the MTT assay. The maximum percentage of growth inhibition was 75.1 ± 7.78%, which was obtained at 6 mg/ml concentration.
22.4.5 Anti-diabetic Effect
After menopause, women’s glucose tolerance capacities deteriorate and accumulate
central fat. As a consequence of these menopausal changes, many menopausal
women have an experience in insulin resistance. Although some epidemiological
and clinical trial studies have reported that isoflavones has a beneficial effect on
insulin sensitivity and glucose metabolism, it is consistent in that isoflavones has
slight decreasing insulin resistance observed after menopause. Recent meta-analysis of randomized clinical trials supports the weak effect of isoflavones for diabetes
and shows no sufficient evidence in improving glycaemic condition (Ricci et al.
2010). Despite the limited evidences, fermented soy products may have better
effects in preventing the progression of type 2 diabetes relative to nonfermented soy
products (Kwon et al. 2010). In normoglycemic women, isoflavones is expected to
have an association with reduced insulin resistance. In summary, the effect of isoflavones as a treatment medicine for diabetes has no compelling evidences, however,
they seem to have a mild effect in preventing diabetes through reducing insulin
resistance.
22.4.6 Antiaging Effects of Isoflavones
Red clover extract which is rich in isoflavones mainly, formonetin and biochanin A
exerts a higher affinity for liposome formation in comparison to genistein and daidzein. Liposome-incorporated red clover extract resulted in a final product with significant antioxidant action as well as additional benefits in aging prevention (Klejdus
et al. 2001; Kanouni et al. 2002).
Soy isoflavones demonstrated UVB protective effects due to their antioxidant
activities (Chiang et al. 2007). In addition, soy isoflavone extract inhibited UVBinduced keratinocyte death and suppressed UVB-induced intracellular H 2 O 2 release,
decreased the epidermal thickness and inhibited COX-2 and proliferating cell
nuclear antigen (PCNA) expression. UVB-triggered activation of p38, c-Jun
N-terminal kinase (JNK) and extracellular signal regulated kinase (ERK1/2) which
were inhibited by treatment with a soy isoflavone extract (Chiang et al. 2007; Chiu
et al. 2009; Assefa et al. 2005).
Huang et al. (2010) evaluated the protective effects of soy isoflavone extract
fraction 3 from soybean cake that contains the aglycone group (daidzein, genistein
and glycitein) and acetylglucoside group (acetyldaidzin, acetylgenistin and acetylglycitin) on UVB-induced damage. The fraction inhibit UVB-induced death of
human keratinocytes and reduce the level of desquamation, transepidermal water
22 Health Benefits of Isoflavones Found Exclusively of Plants of the Fabaceae Family