380
Grindlay D, Reynolds T (1986) The Aloe vera phenomenon: a review of the properties and modern
uses of the leaf parenchyma gel. J Ethnopharmacol 16(2–3):117–151
Guessan KE, Kouakou TH (2017) Phytochemical and evaluation of hypoglycemic effect of leaves
extract of Aloe buettneri A. Berger (liliaceae) in normal and alloxan-induced diabetic mice. J
Pharmacogn Phytochem 6(5):768–775
Guo X, Mei N (2016) Aloe vera: a review of toxicity and adverse clinical effects. J Environ Sci
Health C Environ Carcinog Ecotoxicol Rev 34(2):77–96
Guo L, Mei N, Xia Q, Chen T, Chan PC, Fu PP (2010) Gene expression profiling as an initial
approach for mechanistic studies of toxicity and tumorigenicity of herbal plants and herbal
dietary supplements. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 28:60–87
Guo X, Zhang S, Dial SL, Boudreau MD, Xia Q, Fu PP, Levy DD, Moore MM, Mei N (2014)
In vitro investigation of the mutagenic potential of Aloevera extracts. Toxicol Res 3:487–496
Gutterman Y, Chauser-Volfson E (2000) The distribution of the phenolic metabolites barbaloin,
aloeresin and aloenin as a peripheral defense strategy in the succulent leaf parts of Aloe arborescens. Biochem Syst Ecol 28(9):825–838
Hamiza O, Rehman M, Khan R, Tahir M, Khan A, Lateef A, Sultana S (2014) Chemopreventive
effects of aloin against 1,2-dimethylhydrazine-induced preneoplastic lesions in the colon of
wistar rats. Hum Exp Toxicol 33:148–163. https://doi.org/10.1177/0960327113493307
Hammeso WW, Emiru YK, Getahun KA, Kahaliw W (2019) Antidiabetic and Antihyperlipidemic
activities of the leaf latex extract of Aloe megalacantha Baker (Aloaceae) in Streptozotocininduced diabetic model. Evid Based Complementary Alternat Med, Article ID 8263786, 9
pages, 2019. https://doi.org/10.1155/2019/8263786
Haroon SM, Shahid S, Hussain SA, Raza H (2018) Comparative study of antioxidant activity of
flower of Aloe vera and Leaf extract of Aloe ferox. J Basic Appl Sci 14:191–196
Heggers JP, Kucukcelebi A et al (1995) Wound healing effects of Aloe gel and other topical antibacterial agents on rat skin. Phytother Res 9(6):455–457
Herlihy JT, Bertrand HA, Kim JD, Ikeno Y, Yu BP (1998a) Effects of aloe vera ingestion in the rat
I. growth, food and fluid intake and serum chemistry. Phytother Res 12:183–188
Herlihy JT, Kim JD, Katu DN, Nelson JF, Ward WF, Ikeno Y, Yu BP (1998b) Effects of aloe vera
ingestion in the rat. II. Hormonal and metabolic characteristics. Phytother Res 12:355–360
Holland P (1978) An evolutionary biogeography of the genus Aloe. J Biogeogr 5:213–226
Holzapfel CW, Wessels PL, Van Wyk BE, Marais W, Portwig M (1997) Chromone and aloin derivatives from Aloe broomii, A. Africana and A. speciosa. Phytochemistry 45:97
Hu Y, Xu J et al (2003) Evaluation of antioxidant potential of Aloe vera (Aloe barbadensis Miller)
extracts. J Agric Food Chem 51(26):7788–7791
Huseini HF, Kianbakht S, Hajiaghaee R, Dabaghian FH (2012) Anti-hyperglycemic and antihypercholesterolemic effects of Aloe vera leaf gel in hyperlipidemic type 2 diabetic patients:
A randomized double-blind placebo-controlled clinical trial. Planta Med 78:311–316. https://
doi.org/10.1055/s-0031-1280474
Hutter JA, Salman M, Stavinoha WB, Satsangi N, Williams RF, Streeper RT, Weintraub ST (1996)
Antiinflammatory C-glucosyl chromone from Aloe barbadensis, J Nat Prod 59:541
IASC (2013) Aloe vera quality standard. International Aloe Science Council, Silver Spring, MD,
USA. Available from: http://iasc.org/pdfs/AloeVeraQualityStandard.pdf. Accessed 3 June 2014
Jahanian E, Karimifar M, Rafieian-Kopaei M (2016) Antioxidants as a novel way to alleviate the
adverse effects of oxidative stress in osteoporosis. J Parathyr Dis 4(2):60–65.
Jain N, Vijayaraghavan R, Pant SC, Lomash V, Ali M (2010) Aloe vera gel alleviates cardiotoxicity in streptozocin-induced diabetes in rats. J Pharm Pharmacol 62:115–123. https://doi.
org/10.1211/jpp.62.01.0013
Jia Q, Farrow TM (2005) 7-Hydroxy Chromones as potent antioxidants. 6,884,783. U.S. Patent.
2005 Apr 26
Jia Y, Zhao G, Jia J (2008) Preliminary evaluation: the effects of Aloe ferox Miller and Aloe arborescens Miller on wound healing. J Ethnopharmacol 120(2):181–189
C. Egbuna et al.
Grindlay D, Reynolds T (1986) The Aloe vera phenomenon: a review of the properties and modern
uses of the leaf parenchyma gel. J Ethnopharmacol 16(2–3):117–151
Guessan KE, Kouakou TH (2017) Phytochemical and evaluation of hypoglycemic effect of leaves
extract of Aloe buettneri A. Berger (liliaceae) in normal and alloxan-induced diabetic mice. J
Pharmacogn Phytochem 6(5):768–775
Guo X, Mei N (2016) Aloe vera: a review of toxicity and adverse clinical effects. J Environ Sci
Health C Environ Carcinog Ecotoxicol Rev 34(2):77–96
Guo L, Mei N, Xia Q, Chen T, Chan PC, Fu PP (2010) Gene expression profiling as an initial
approach for mechanistic studies of toxicity and tumorigenicity of herbal plants and herbal
dietary supplements. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 28:60–87
Guo X, Zhang S, Dial SL, Boudreau MD, Xia Q, Fu PP, Levy DD, Moore MM, Mei N (2014)
In vitro investigation of the mutagenic potential of Aloevera extracts. Toxicol Res 3:487–496
Gutterman Y, Chauser-Volfson E (2000) The distribution of the phenolic metabolites barbaloin,
aloeresin and aloenin as a peripheral defense strategy in the succulent leaf parts of Aloe arborescens. Biochem Syst Ecol 28(9):825–838
Hamiza O, Rehman M, Khan R, Tahir M, Khan A, Lateef A, Sultana S (2014) Chemopreventive
effects of aloin against 1,2-dimethylhydrazine-induced preneoplastic lesions in the colon of
wistar rats. Hum Exp Toxicol 33:148–163. https://doi.org/10.1177/0960327113493307
Hammeso WW, Emiru YK, Getahun KA, Kahaliw W (2019) Antidiabetic and Antihyperlipidemic
activities of the leaf latex extract of Aloe megalacantha Baker (Aloaceae) in Streptozotocininduced diabetic model. Evid Based Complementary Alternat Med, Article ID 8263786, 9
pages, 2019. https://doi.org/10.1155/2019/8263786
Haroon SM, Shahid S, Hussain SA, Raza H (2018) Comparative study of antioxidant activity of
flower of Aloe vera and Leaf extract of Aloe ferox. J Basic Appl Sci 14:191–196
Heggers JP, Kucukcelebi A et al (1995) Wound healing effects of Aloe gel and other topical antibacterial agents on rat skin. Phytother Res 9(6):455–457
Herlihy JT, Bertrand HA, Kim JD, Ikeno Y, Yu BP (1998a) Effects of aloe vera ingestion in the rat
I. growth, food and fluid intake and serum chemistry. Phytother Res 12:183–188
Herlihy JT, Kim JD, Katu DN, Nelson JF, Ward WF, Ikeno Y, Yu BP (1998b) Effects of aloe vera
ingestion in the rat. II. Hormonal and metabolic characteristics. Phytother Res 12:355–360
Holland P (1978) An evolutionary biogeography of the genus Aloe. J Biogeogr 5:213–226
Holzapfel CW, Wessels PL, Van Wyk BE, Marais W, Portwig M (1997) Chromone and aloin derivatives from Aloe broomii, A. Africana and A. speciosa. Phytochemistry 45:97
Hu Y, Xu J et al (2003) Evaluation of antioxidant potential of Aloe vera (Aloe barbadensis Miller)
extracts. J Agric Food Chem 51(26):7788–7791
Huseini HF, Kianbakht S, Hajiaghaee R, Dabaghian FH (2012) Anti-hyperglycemic and antihypercholesterolemic effects of Aloe vera leaf gel in hyperlipidemic type 2 diabetic patients:
A randomized double-blind placebo-controlled clinical trial. Planta Med 78:311–316. https://
doi.org/10.1055/s-0031-1280474
Hutter JA, Salman M, Stavinoha WB, Satsangi N, Williams RF, Streeper RT, Weintraub ST (1996)
Antiinflammatory C-glucosyl chromone from Aloe barbadensis, J Nat Prod 59:541
IASC (2013) Aloe vera quality standard. International Aloe Science Council, Silver Spring, MD,
USA. Available from: http://iasc.org/pdfs/AloeVeraQualityStandard.pdf. Accessed 3 June 2014
Jahanian E, Karimifar M, Rafieian-Kopaei M (2016) Antioxidants as a novel way to alleviate the
adverse effects of oxidative stress in osteoporosis. J Parathyr Dis 4(2):60–65.
Jain N, Vijayaraghavan R, Pant SC, Lomash V, Ali M (2010) Aloe vera gel alleviates cardiotoxicity in streptozocin-induced diabetes in rats. J Pharm Pharmacol 62:115–123. https://doi.
org/10.1211/jpp.62.01.0013
Jia Q, Farrow TM (2005) 7-Hydroxy Chromones as potent antioxidants. 6,884,783. U.S. Patent.
2005 Apr 26
Jia Y, Zhao G, Jia J (2008) Preliminary evaluation: the effects of Aloe ferox Miller and Aloe arborescens Miller on wound healing. J Ethnopharmacol 120(2):181–189
C. Egbuna et al.