ε
[cm
−1
M
−1
]
μ
a
>
Frequency (cm
−1 )
10
20
30
40
50
400
300
200
100
0
250
200
150
100
50
0
0.5
Frequency (cm
−1 )
Segelstein et al. (1981)
Venables et al. (2000)
Thrane et al. (1995)
Jepsen et al. (2007)
Hasted et al. (1987)
Barthel et al. (1990)
300
200
100
O
1.6
1.4
H
H
H
H
O
O
O
H
H
Tetrahedral arrangement of
O
H H δ +
H H
δ
−
1.2
1
0.8
0.6
0.4
intermolecular hydrogen bonds
0.2
Frequency (THz)
Water + protein
10 K
T
DNA
300 K
(a)
G
C
A
1.0 1.5 2.0 2.5 3.0 3.5 4.0
Frequency (THz)
10
30
50
90
70
110
130
A (×3)
(b)
(c)
374
Electromagnetic Fields in Biological Systems
Figure 7.2 (See color insert.) (a) Frequency-dependent absorption coefficient of water and
image of hydrogen bonds in water. (Data from Segelstein, D. 1981. The Complex Refractive Index
of Water. Kansas City, MO: University of Missouri; Hasted, J. B., S. K. Husain et al. 1987. Infrared
Phys 27(1):11–5; Barthel, J., and H. Hetzenauer. 1990. Dielectric Specta of Some Common Solvents
in the Microwave Region, Water and Lower Alcohols. Amsterdam: Elsevier; Thrane, L., R. H.
Jacobsen et al. 1995. Chem Phys Lett 240(4):330–3; Venables, D., and C. Schmuttenmaer. 2000.
J Chem Phys 113(24):11222–36; Jepsen, P. U., U. Moller et al. 2007. Opt Express 15(22):14717–37.)
Hydrogen-bond rearrangements, intermolecular bends, occur on the picosecond timescale, corresponding to 40–60 cm −1 . (b) Frequency dependent absorption coefficient of DNA nucleobases A,
C, T, and G. Each nucleobase has unique spectral resonances from 0.5 to 4.0 THz. (Reprinted with
permission from Fischer, B. M., M. Walther et al. 2002. Phys Med Biol 47(21):3807–14.) (c) Cartoon
of water molecules dancing around a protein molecule. (Reprinted with permission from Leitner,
D. M., M. Gruebele et al. 2008. HFSP J 2(6):314–23.)
[cm
−1
M
−1
]
μ
a
>
Frequency (cm
−1 )
10
20
30
40
50
400
300
200
100
0
250
200
150
100
50
0
0.5
Frequency (cm
−1 )
Segelstein et al. (1981)
Venables et al. (2000)
Thrane et al. (1995)
Jepsen et al. (2007)
Hasted et al. (1987)
Barthel et al. (1990)
300
200
100
O
1.6
1.4
H
H
H
H
O
O
O
H
H
Tetrahedral arrangement of
O
H H δ +
H H
δ
−
1.2
1
0.8
0.6
0.4
intermolecular hydrogen bonds
0.2
Frequency (THz)
Water + protein
10 K
T
DNA
300 K
(a)
G
C
A
1.0 1.5 2.0 2.5 3.0 3.5 4.0
Frequency (THz)
10
30
50
90
70
110
130
A (×3)
(b)
(c)
374
Electromagnetic Fields in Biological Systems
Figure 7.2 (See color insert.) (a) Frequency-dependent absorption coefficient of water and
image of hydrogen bonds in water. (Data from Segelstein, D. 1981. The Complex Refractive Index
of Water. Kansas City, MO: University of Missouri; Hasted, J. B., S. K. Husain et al. 1987. Infrared
Phys 27(1):11–5; Barthel, J., and H. Hetzenauer. 1990. Dielectric Specta of Some Common Solvents
in the Microwave Region, Water and Lower Alcohols. Amsterdam: Elsevier; Thrane, L., R. H.
Jacobsen et al. 1995. Chem Phys Lett 240(4):330–3; Venables, D., and C. Schmuttenmaer. 2000.
J Chem Phys 113(24):11222–36; Jepsen, P. U., U. Moller et al. 2007. Opt Express 15(22):14717–37.)
Hydrogen-bond rearrangements, intermolecular bends, occur on the picosecond timescale, corresponding to 40–60 cm −1 . (b) Frequency dependent absorption coefficient of DNA nucleobases A,
C, T, and G. Each nucleobase has unique spectral resonances from 0.5 to 4.0 THz. (Reprinted with
permission from Fischer, B. M., M. Walther et al. 2002. Phys Med Biol 47(21):3807–14.) (c) Cartoon
of water molecules dancing around a protein molecule. (Reprinted with permission from Leitner,
D. M., M. Gruebele et al. 2008. HFSP J 2(6):314–23.)