Bäuerlein PS, ter Laak TL, Hofman-Caris RCHM, de Voogt P, Droge STJ (2012) Removal of
charged micropollutants from water by ion-exchange polymers – effects of competing electrolytes. Water Res 46(16):5009–5018. https://doi.org/10.1016/j.watres.2012.06.048
Baumer A, Bittermann K, Kluver N, Escher BI (2017) Baseline toxicity and ion-trapping models to
describe the pH-dependence of bacterial toxicity of pharmaceuticals. Environ Sci Proc Imp.
https://doi.org/10.1039/C7EM00099E
Benedetti MF, Van Riemsdijk WH, Koopal LK (1996) Humic substances considered as a heterogeneous Donnan gel phase. Environ Sci Technol 30(6):1805–1813. https://doi.org/10.1021/
es950012y
Benz R (1988) Structural requirement for the rapid movement of charged molecules across
membranes. Experiments with tetraphenylborate analogues. Biophys J 54(1):25–33. https://
doi.org/10.1016/S0006-3495(88)82927-8
Bischel HN, MacManus-Spencer LA, Zhang C, Luthy RG (2011) Strong associations of shortchain perfluoroalkyl acids with serum albumin and investigation of binding mechanisms.
Environ Toxicol Chem 30(11):2423–2430. https://doi.org/10.1002/etc.647
Bittermann K, Goss K-U (2017) Assessing the toxicity of ionic liquids – application of the critical
membrane concentration approach. Chemosphere 183(Suppl C):410–418. https://doi.org/10.
1016/j.chemosphere.2017.05.097
Bittermann K, Spycher S, Endo S et al (2014) Prediction of phospholipid–water partition coefficients of ionic organic chemicals using the mechanistic model COSMOmic. J Phys Chem B
118(51):14833–14842. https://doi.org/10.1021/jp509348a
Bittermann K, Spycher S, Goss K-U (2016) Comparison of different models predicting the
phospholipid-membrane water partition coefficients of charged compounds. Chemosphere
144:382–391. https://doi.org/10.1016/j.chemosphere.2015.08.065
Bittermann K, Linden L, Goss K-U (2018) Screening tools for the bioconcentration potential
of monovalent organic ions in fish. Environ Sci: Processes Impacts. https://doi.org/10.1039/
C8EM00084K
Bittner L, Teixido E, Seiwert B, Escher BI, Klüver N (2018) Influence of pH on the uptake and
toxicity of β-blockers in embryos of zebrafish, Danio rerio. Aquat Toxicol 201:129–137. https://
doi.org/10.1016/j.aquatox.2018.05.020
Boström ML, Berglund O (2015) Influence of pH-dependent aquatic toxicity of ionizable pharmaceuticals on risk assessments over environmental pH ranges. Water Res 72(Suppl C):154–161.
https://doi.org/10.1016/j.watres.2014.08.040
Broeders JJW, Blaauboer BJ, Hermens JLM (2011) Development of a negligible depletion-solid
phase microextraction method to determine the free concentration of chlorpromazine in aqueous
samples containing albumin. J Chromatogr A 1218(47):8529–8535. https://doi.org/10.1016/j.
chroma.2011.09.064
Carrasquillo AJ, Bruland GL, MacKay AA, Vasudevan D (2008) Sorption of ciprofloxacin and
oxytetracycline zwitterions to soils and soil minerals: influence of compound structure. Environ
Sci Technol 42(20):7634–7642. https://doi.org/10.1021/es801277y
Chen Y, Droge STJ, Hermens JLM (2012) Analyzing freely dissolved concentrations of cationic
surfactant utilizing ion-exchange capability of polyacrylate coated solid-phase microextraction
fibers. J Chromatogr A 1252:15–22. https://doi.org/10.1016/j.chroma.2012.06.080
Chen Y, Hermens JLM, Droge STJ (2013) Influence of organic matter type and medium composition on the sorption affinity of C12-benzalkonium cation. Environ Pollut 179:153–159. https://
doi.org/10.1016/j.envpol.2013.04.017
Chen Y, Hermens JLM, Jonker MTO et al (2016) Which molecular features affect the intrinsic
hepatic clearance rate of ionizable organic chemicals in fish? Environ Sci Technol 50
(23):12722–12731. https://doi.org/10.1021/acs.est.6b03504
Claßen D, Ackermann J, Brendel S (2016) Bewertung persistenter, bioakkumulierender und
toxischer Eigenschaften von ionischen und ionisierbaren Stoffen. Mitteilungen der Fachgruppe
Umweltchemie und Ökotoxikologie Heft 2:33–36
Collins KD, Neilson GW, Enderby JE (2007) Ions in water: characterizing the forces that control
chemical processes and biological structure. Biophys Chem 128(2–3):95
58
L. Henneberger and K.-U. Goss
charged micropollutants from water by ion-exchange polymers – effects of competing electrolytes. Water Res 46(16):5009–5018. https://doi.org/10.1016/j.watres.2012.06.048
Baumer A, Bittermann K, Kluver N, Escher BI (2017) Baseline toxicity and ion-trapping models to
describe the pH-dependence of bacterial toxicity of pharmaceuticals. Environ Sci Proc Imp.
https://doi.org/10.1039/C7EM00099E
Benedetti MF, Van Riemsdijk WH, Koopal LK (1996) Humic substances considered as a heterogeneous Donnan gel phase. Environ Sci Technol 30(6):1805–1813. https://doi.org/10.1021/
es950012y
Benz R (1988) Structural requirement for the rapid movement of charged molecules across
membranes. Experiments with tetraphenylborate analogues. Biophys J 54(1):25–33. https://
doi.org/10.1016/S0006-3495(88)82927-8
Bischel HN, MacManus-Spencer LA, Zhang C, Luthy RG (2011) Strong associations of shortchain perfluoroalkyl acids with serum albumin and investigation of binding mechanisms.
Environ Toxicol Chem 30(11):2423–2430. https://doi.org/10.1002/etc.647
Bittermann K, Goss K-U (2017) Assessing the toxicity of ionic liquids – application of the critical
membrane concentration approach. Chemosphere 183(Suppl C):410–418. https://doi.org/10.
1016/j.chemosphere.2017.05.097
Bittermann K, Spycher S, Endo S et al (2014) Prediction of phospholipid–water partition coefficients of ionic organic chemicals using the mechanistic model COSMOmic. J Phys Chem B
118(51):14833–14842. https://doi.org/10.1021/jp509348a
Bittermann K, Spycher S, Goss K-U (2016) Comparison of different models predicting the
phospholipid-membrane water partition coefficients of charged compounds. Chemosphere
144:382–391. https://doi.org/10.1016/j.chemosphere.2015.08.065
Bittermann K, Linden L, Goss K-U (2018) Screening tools for the bioconcentration potential
of monovalent organic ions in fish. Environ Sci: Processes Impacts. https://doi.org/10.1039/
C8EM00084K
Bittner L, Teixido E, Seiwert B, Escher BI, Klüver N (2018) Influence of pH on the uptake and
toxicity of β-blockers in embryos of zebrafish, Danio rerio. Aquat Toxicol 201:129–137. https://
doi.org/10.1016/j.aquatox.2018.05.020
Boström ML, Berglund O (2015) Influence of pH-dependent aquatic toxicity of ionizable pharmaceuticals on risk assessments over environmental pH ranges. Water Res 72(Suppl C):154–161.
https://doi.org/10.1016/j.watres.2014.08.040
Broeders JJW, Blaauboer BJ, Hermens JLM (2011) Development of a negligible depletion-solid
phase microextraction method to determine the free concentration of chlorpromazine in aqueous
samples containing albumin. J Chromatogr A 1218(47):8529–8535. https://doi.org/10.1016/j.
chroma.2011.09.064
Carrasquillo AJ, Bruland GL, MacKay AA, Vasudevan D (2008) Sorption of ciprofloxacin and
oxytetracycline zwitterions to soils and soil minerals: influence of compound structure. Environ
Sci Technol 42(20):7634–7642. https://doi.org/10.1021/es801277y
Chen Y, Droge STJ, Hermens JLM (2012) Analyzing freely dissolved concentrations of cationic
surfactant utilizing ion-exchange capability of polyacrylate coated solid-phase microextraction
fibers. J Chromatogr A 1252:15–22. https://doi.org/10.1016/j.chroma.2012.06.080
Chen Y, Hermens JLM, Droge STJ (2013) Influence of organic matter type and medium composition on the sorption affinity of C12-benzalkonium cation. Environ Pollut 179:153–159. https://
doi.org/10.1016/j.envpol.2013.04.017
Chen Y, Hermens JLM, Jonker MTO et al (2016) Which molecular features affect the intrinsic
hepatic clearance rate of ionizable organic chemicals in fish? Environ Sci Technol 50
(23):12722–12731. https://doi.org/10.1021/acs.est.6b03504
Claßen D, Ackermann J, Brendel S (2016) Bewertung persistenter, bioakkumulierender und
toxischer Eigenschaften von ionischen und ionisierbaren Stoffen. Mitteilungen der Fachgruppe
Umweltchemie und Ökotoxikologie Heft 2:33–36
Collins KD, Neilson GW, Enderby JE (2007) Ions in water: characterizing the forces that control
chemical processes and biological structure. Biophys Chem 128(2–3):95
58
L. Henneberger and K.-U. Goss