178
P. Madiwale et al.
Table 3 Method of preparation of silk fibroin scaffolds and its application for various tissue
regeneration [32–35]
Composition (SF—silk fibroin)
Method
Tissue/organ
SF
Lyophilisation
Neural
SF
Lyophilized, redissolved in
Hexa-Fluoro-Iso-propanol (HFIP),
dried
Bone
SF
Chemical cross
linking/lyophilisation
Bone
SF
Lyophilisation
Cartilage
SF
Dried 24 h
Cartilage
SF
Lyophilisation 24 h (microporous
silk sponges)
Ligament and tendon
SF fibres
Braided on polyvinyl chloride rod
Vascular
SF/collagen
Physical cross linking (thin films)
Hepatic tissue
SF/collagen
Chemical cross linking (genipin
powder as cross linker)
Bone
SF/hyaluronic acid
Physical cross linking (silk
conduits)
Neural
SF/chitosan
Lyophilisation (sheet structure)
Neural
SF/chitosan
Chemical cross linking (genipin
powder as cross linker)
Cartilage
SF/alginate
Lyophilisation (stripe-type porous
morphology)
Skin
SF/hyaluronic acid
Chemical cross linking (genipin
powder as cross linker) (patched
geometry)
Cardiac
SF/collagen/heparin
Lyophilisation (stripe-type porous
morphology)
Skin
SF/cyclodextrin
Lyophilisation (channel structure)
No application yet
SF/PEO
Electrospun silk
Vascular
SF/PEO
Dried to form thin Fibroin
membranes
No application yet
SF/PEO
Electrospun silk
Bone
SF/P(LLA-CL)
Electrospun silk (conduit)
Neural
SF/PLGA
Electrospun silk
Ligament and tendon
SF/cyclic olefin copolymer
Dried
Ocular
SF/PNIPAM
Chemical cross linking (BIS)
No application yet