Preface
The authors dedicate this work to Rolf Huisgen and his many coworkers, the
architects of a tremendous portion of the 1,3-dipole chemistry in use today.
We also wish to clarify a handful of technical details relating to the construction
of this manuscript. Firstly, all reported products of 1,3-dipolar cycloaddition
reactions afford a single or extremely dominant regioisomer unless otherwise
indicated.
Additionally, the literature concerning NIs is dominated by 1,3-dipolar
cycloadditions with alkenes, and this may appear disproportionate relative to the
page allocation for different NI reaction partners within the Reactivity section of this
book. We have taken this decision for two reasons. Firstly, the majority of examples
of NI-alkene cycloadditions not reported herein apply this reaction as a means to an
end and is not the primary focus of the manuscript. All relevant articles that in some
manner further the understanding of, or expand the application scope of, the
NI-alkene cycloaddition have been included within this book, along with other
selected examples. Secondly, the principal objective of the Reactivity section of this
work is to provide a complete and balanced overview of all potential reaction
partners. A vast excess of NI-alkene cycloaddition methodology would only dilute
the impact and compromise the structuring of this section.
This book is intended to provide complete, authoritative coverage of the literature up to May 2019 (inclusive). While a handful of citations after this date are
included, the authors must stress that it is possible that some publications after this
time may have been overlooked due to the preparation of the manuscript taking
place during this period.
Glasgow, UK
Craig Jamieson
Keith Livingstone
v
The authors dedicate this work to Rolf Huisgen and his many coworkers, the
architects of a tremendous portion of the 1,3-dipole chemistry in use today.
We also wish to clarify a handful of technical details relating to the construction
of this manuscript. Firstly, all reported products of 1,3-dipolar cycloaddition
reactions afford a single or extremely dominant regioisomer unless otherwise
indicated.
Additionally, the literature concerning NIs is dominated by 1,3-dipolar
cycloadditions with alkenes, and this may appear disproportionate relative to the
page allocation for different NI reaction partners within the Reactivity section of this
book. We have taken this decision for two reasons. Firstly, the majority of examples
of NI-alkene cycloadditions not reported herein apply this reaction as a means to an
end and is not the primary focus of the manuscript. All relevant articles that in some
manner further the understanding of, or expand the application scope of, the
NI-alkene cycloaddition have been included within this book, along with other
selected examples. Secondly, the principal objective of the Reactivity section of this
work is to provide a complete and balanced overview of all potential reaction
partners. A vast excess of NI-alkene cycloaddition methodology would only dilute
the impact and compromise the structuring of this section.
This book is intended to provide complete, authoritative coverage of the literature up to May 2019 (inclusive). While a handful of citations after this date are
included, the authors must stress that it is possible that some publications after this
time may have been overlooked due to the preparation of the manuscript taking
place during this period.
Glasgow, UK
Craig Jamieson
Keith Livingstone
v