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4. Baruah KA, Prajapati D, Sandhu JS (1988) Studies in chromone derivatives: cycloaddition reactions of 4-oxo 4H-1-Benzopyran-3-Carboxaldehyde Imines with Benzonitrile Oxide
and Nitrilimine of 4-Oxo-4H-1-Benzopyran-3-Carboxaldehyde with Alkenes. Tetrahedron
44:1241–1246
5. Blake AJ, Cook TA, Forsyth AC, Gould RO, Paton RM (1992) 1,3-dipolar cycloaddition
reactions of Levoglucosenone. Tetrahedron 48:8053–8064
6. Alizadeh A, Amir Ashjaee Asalemi K, Halvagar M (2019) Intramolecular Diels–Alder and
[3+2] cycloaddition reactions in the one-pot synthesis of Epoxypyrrolo[3,4-g]indazoles.
Synthesis (Stuttg)
7. Green B, Sheu K (1994) Synthesis of steroidal D-Ring fused pyrazolines: study of
regiochemistry of addition. Steroids 59:479–484
8. Mernyák E, Kozma E, Hetényi A, Márk L, Schneidera G, Wölfling J (2009) Stereoselective synthesis of spiro and condensed Pyrazolines of steroidal α, β-unsaturated Ketones and
Nitrilimines by 1,3-dipolar cycloaddition. Steroids 74:520–525
9. Bach KK, El-Seedi HR, Jensen HM, Nielsen HB, Thomsen I, Torssell KBG (1994) 1,3-Dipolar
Cycloadditions of Ethoxycarbonyl-Nitrile Benzylimine, EtOOCC=N+ − N- –CH 2 C 6 H 5 , and
synthesis of β-Amino acids. Synthesis and reactions of Ethyl 2-Chloro-2-ethoxyacetate and
2-Chloro-2-Ethoxyacetyl Chloride. Tetrahedron 50:7543–7556
10. Wang Y, Lin Q (2009) Synthesis and evaluation of photoreactive tetrazole amino acids. Org
Lett 11:3570–3573
11. Pla D, Tan DS, Gin DY (2014) 5-(Methylthio)tetrazoles as versatile Synthons in the
stereoselective synthesis of polycyclic Pyrazolines via photoinduced intramolecular Nitrile
Imine-Alkene 1,3-dipolar cycloaddition. Chem Sci 5:2407–2415
12. Adelstein GW (1973) Antiarrhythmic agents. Synthesis and biological activity of some
Tetrazole and Oxadiazole analogs of 4-Dialkylamino-2,2-Diarylbutyramides. J Med Chem
16:309–312
13. Garofalo AW, Jagodzinski JJ, Konradi AW, Ng RA, Semko CM, Sham HL, Sun M, Ye
XM, Garofalo AW, Jagodzinski JJ, Konradi AW, Ng RA, Semko CM, Sham HL, Sun M, Ye
XM (2012) Synthesis of Novel Tetrahydro-1H-pyrazolo[4,3-c]pyridines via intramolecular
Nitrilimine cycloaddition. Chem Pharm Bull 60:1063–1066
14. Pinto DJP, Orwat MJ, Koch S, Rossi KA, Alexander Richard S, Smallwood A, Wong
PC, Rendina AR, Luettgen JM, Knabb RM, He K, Xin B, Wexler RR, Lam PYS
(2007) Discovery of 1-(4-Methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide (Apixaban, BMS-562247), a highly
potent, selective, efficacious, and orally bioavailable inhibitor of blood coagulation F. J Med
Chem 50:5339–5356
15. Conti P, di Ventimiglia SJ, Pinto A, Tamborini L, Menniti FS, Lazzaro JT, De Micheli C
(2008) Synthesis of Novel Pyrrolo[3,4-d]pyrazole-dicarboxylic acids and evaluation of their
interaction with glutamate receptors. Chem Biodivers 5:657–663
16. Pfefferkorn JA, Choi C, Larsen SD, Auerbach B, Hutchings R, Park W, Askew V, Dillon L,
Hanselman JC, Lin Z, Lu GH, Robertson A, Sekerke C, Harris MS, Pavlovsky A, Bainbridge
G, Caspers N, Kowala M, Tait BD (2008) Substituted Pyrazoles as Hepatoselective HMGCoA reductase inhibitors: discovery of (3R,5R)-7-[2-(4-Fluoro-phenyl)-4-isopropyl-5-(4methyl-benzylcarbamoyl)-2H-pyrazol-3-yl]-3,5-dihydroxyheptanoic acid (PF-3052334) as a
candidate for the treatment of hypercholesterolemia. J Med Chem 51:31–34
17. Bertuzzi G, Locatelli E, Colecchia D, Calandro P, Bonini BF, Chandanshive JZ, Mazzanti
A, Zani P, Chiariello M, Comes Franchini M (2016) Straightforward synthesis of a novel
ring-fused Pyrazole-Lactam and in vitro cytotoxic activity on cancer cell lines. Eur J Med
Chem 117:1–7
18. Silvestri R, Cascio MG, La Regina G, Piscitelli F, Lavecchia A, Brizzi A, Pasquini S,
Botta M, Novellino E, Di Marzo V, Corelli F (2008) Synthesis, Cannabinoid receptor affinity, and molecular modeling studies of substituted 1-Aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3carboxamides. J Med Chem 51:1560–1576
143
4. Baruah KA, Prajapati D, Sandhu JS (1988) Studies in chromone derivatives: cycloaddition reactions of 4-oxo 4H-1-Benzopyran-3-Carboxaldehyde Imines with Benzonitrile Oxide
and Nitrilimine of 4-Oxo-4H-1-Benzopyran-3-Carboxaldehyde with Alkenes. Tetrahedron
44:1241–1246
5. Blake AJ, Cook TA, Forsyth AC, Gould RO, Paton RM (1992) 1,3-dipolar cycloaddition
reactions of Levoglucosenone. Tetrahedron 48:8053–8064
6. Alizadeh A, Amir Ashjaee Asalemi K, Halvagar M (2019) Intramolecular Diels–Alder and
[3+2] cycloaddition reactions in the one-pot synthesis of Epoxypyrrolo[3,4-g]indazoles.
Synthesis (Stuttg)
7. Green B, Sheu K (1994) Synthesis of steroidal D-Ring fused pyrazolines: study of
regiochemistry of addition. Steroids 59:479–484
8. Mernyák E, Kozma E, Hetényi A, Márk L, Schneidera G, Wölfling J (2009) Stereoselective synthesis of spiro and condensed Pyrazolines of steroidal α, β-unsaturated Ketones and
Nitrilimines by 1,3-dipolar cycloaddition. Steroids 74:520–525
9. Bach KK, El-Seedi HR, Jensen HM, Nielsen HB, Thomsen I, Torssell KBG (1994) 1,3-Dipolar
Cycloadditions of Ethoxycarbonyl-Nitrile Benzylimine, EtOOCC=N+ − N- –CH 2 C 6 H 5 , and
synthesis of β-Amino acids. Synthesis and reactions of Ethyl 2-Chloro-2-ethoxyacetate and
2-Chloro-2-Ethoxyacetyl Chloride. Tetrahedron 50:7543–7556
10. Wang Y, Lin Q (2009) Synthesis and evaluation of photoreactive tetrazole amino acids. Org
Lett 11:3570–3573
11. Pla D, Tan DS, Gin DY (2014) 5-(Methylthio)tetrazoles as versatile Synthons in the
stereoselective synthesis of polycyclic Pyrazolines via photoinduced intramolecular Nitrile
Imine-Alkene 1,3-dipolar cycloaddition. Chem Sci 5:2407–2415
12. Adelstein GW (1973) Antiarrhythmic agents. Synthesis and biological activity of some
Tetrazole and Oxadiazole analogs of 4-Dialkylamino-2,2-Diarylbutyramides. J Med Chem
16:309–312
13. Garofalo AW, Jagodzinski JJ, Konradi AW, Ng RA, Semko CM, Sham HL, Sun M, Ye
XM, Garofalo AW, Jagodzinski JJ, Konradi AW, Ng RA, Semko CM, Sham HL, Sun M, Ye
XM (2012) Synthesis of Novel Tetrahydro-1H-pyrazolo[4,3-c]pyridines via intramolecular
Nitrilimine cycloaddition. Chem Pharm Bull 60:1063–1066
14. Pinto DJP, Orwat MJ, Koch S, Rossi KA, Alexander Richard S, Smallwood A, Wong
PC, Rendina AR, Luettgen JM, Knabb RM, He K, Xin B, Wexler RR, Lam PYS
(2007) Discovery of 1-(4-Methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide (Apixaban, BMS-562247), a highly
potent, selective, efficacious, and orally bioavailable inhibitor of blood coagulation F. J Med
Chem 50:5339–5356
15. Conti P, di Ventimiglia SJ, Pinto A, Tamborini L, Menniti FS, Lazzaro JT, De Micheli C
(2008) Synthesis of Novel Pyrrolo[3,4-d]pyrazole-dicarboxylic acids and evaluation of their
interaction with glutamate receptors. Chem Biodivers 5:657–663
16. Pfefferkorn JA, Choi C, Larsen SD, Auerbach B, Hutchings R, Park W, Askew V, Dillon L,
Hanselman JC, Lin Z, Lu GH, Robertson A, Sekerke C, Harris MS, Pavlovsky A, Bainbridge
G, Caspers N, Kowala M, Tait BD (2008) Substituted Pyrazoles as Hepatoselective HMGCoA reductase inhibitors: discovery of (3R,5R)-7-[2-(4-Fluoro-phenyl)-4-isopropyl-5-(4methyl-benzylcarbamoyl)-2H-pyrazol-3-yl]-3,5-dihydroxyheptanoic acid (PF-3052334) as a
candidate for the treatment of hypercholesterolemia. J Med Chem 51:31–34
17. Bertuzzi G, Locatelli E, Colecchia D, Calandro P, Bonini BF, Chandanshive JZ, Mazzanti
A, Zani P, Chiariello M, Comes Franchini M (2016) Straightforward synthesis of a novel
ring-fused Pyrazole-Lactam and in vitro cytotoxic activity on cancer cell lines. Eur J Med
Chem 117:1–7
18. Silvestri R, Cascio MG, La Regina G, Piscitelli F, Lavecchia A, Brizzi A, Pasquini S,
Botta M, Novellino E, Di Marzo V, Corelli F (2008) Synthesis, Cannabinoid receptor affinity, and molecular modeling studies of substituted 1-Aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3carboxamides. J Med Chem 51:1560–1576