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VIII.
Chitosan-based products production
1- Wound healing – anti-inflammatory cream
Chitin and chitosan are biopolymers with excellent bioactive properties, such as
biodegradability, non-toxicity, biocompatibility, haemostatic activity and antimicrobial activity
(NARAYANA et al., 2023). A wide variety of biomedical applications for chitin and chitin
derivatives have been reported, including wound-healing applications. They are reported to
promote rapid dermal regeneration and accelerate wound healing, (SINGH et al., 2017).
In this study, we aimed to produce a chitosan-based creams and evaluate its anti-inflammatory
and wound healing properties by following a specific Saidal formulation.
Procedure:
Preparation of the oily and aqueous phases
➢ The aqueous phase consists of purified water.
Inversion method
• Take the two phases at the same temperature for about 10 minutes.
• Immerse them in the same 70° water bath.
• place the beaker containing the oily phase under mechanical agitation and gradually
add the aqueous phase by stirring about 600 rpm
• continue to agitate until return to T° ambient.
Oily phase
Anti-inflammatorycream
Woundhealingcream
Polysorbate 60
Propylene Glycol
Isopropyl myristate
Myristate
Methyl salicylate
Liquidparaffin
StearylAlcohol
GlycerolMonostearate
CetylAlcohol
Macrogol Stearate
Cetyl palmitate
CetylStearylAlcohol
Sorbitol monostearate
BenzylAlcohol
Figure 40: Ingredients for
Cream preparation