Quantification of Non-steroidal
Anti-inflammatory Drug in Water
Keila Isaac-Olivé, Eunice Olivé-Alvarez, Amado E. Navarro-Frómeta,
Ninfa Ramírez-Durán, Enrique Morales-Avila, Liliana Aranda-Lara,
Horacio Sandoval-Trujillo, and Pablo Moreno-Pérez
Contents
1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 84
2 NSAIDs as Emerging Pollutants . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 84
2.1 NSAIDs Access Routes to the Environment . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 85
2.2 Toxic Effects of NSAIDs at Low Concentrations . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 86
3 Analytical Determination of NSAIDs in Waters of Different Origin . . . . . . . . . . . . . . . . . . . . . . 87
3.1 Main NSAIDs Found in Bodies of Water . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 87
3.2 General Methodology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 87
4 Conclusions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 99
References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 100
Abstract This chapter discusses the main reasons for viewing non-steroidal antiinflammatory drug (NSAIDs) as emerging contaminants. Their access routes into the
environment are specified, in particular into natural and wastewater, and current
evidence about their possible toxic effects is described. Mention is made of the most
commonly used methods for routine determination from sampling to final quantification of NSAIDs in water samples of diverse origins. The most important aspects of
sampling, extraction, and concentration, including microextraction methods, are
K. Isaac-Olivé (*), N. Ramírez-Durán, E. Morales-Avila, L. Aranda-Lara, and
P. Moreno-Pérez
Universidad Autónoma del Estado de México, Toluca, Estado de México, Mexico
e-mail: kisaaco@uaemex.mx
E. Olivé-Alvarez
Centro de Isótopos, La Habana, Cuba
A. E. Navarro-Frómeta
Universidad Tecnológica de Izúcar de Matamoros, Izúcar de Matamoros, Puebla, Mexico
H. Sandoval-Trujillo
Universidad Autónoma Metropolitana-Xochimilco, Ciudad de México, Mexico
Leobardo Manuel Gómez-Oliván (ed.), Non-Steroidal Anti-Inflammatory Drugs
in Water: Emerging Contaminants and Ecological Impact,
Hdb Env Chem (2020) 96: 83–104, DOI 10.1007/698_2020_543,
© Springer Nature Switzerland AG 2020, Published online: 2 July 2020
83
Anti-inflammatory Drug in Water
Keila Isaac-Olivé, Eunice Olivé-Alvarez, Amado E. Navarro-Frómeta,
Ninfa Ramírez-Durán, Enrique Morales-Avila, Liliana Aranda-Lara,
Horacio Sandoval-Trujillo, and Pablo Moreno-Pérez
Contents
1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 84
2 NSAIDs as Emerging Pollutants . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 84
2.1 NSAIDs Access Routes to the Environment . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 85
2.2 Toxic Effects of NSAIDs at Low Concentrations . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 86
3 Analytical Determination of NSAIDs in Waters of Different Origin . . . . . . . . . . . . . . . . . . . . . . 87
3.1 Main NSAIDs Found in Bodies of Water . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 87
3.2 General Methodology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 87
4 Conclusions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 99
References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 100
Abstract This chapter discusses the main reasons for viewing non-steroidal antiinflammatory drug (NSAIDs) as emerging contaminants. Their access routes into the
environment are specified, in particular into natural and wastewater, and current
evidence about their possible toxic effects is described. Mention is made of the most
commonly used methods for routine determination from sampling to final quantification of NSAIDs in water samples of diverse origins. The most important aspects of
sampling, extraction, and concentration, including microextraction methods, are
K. Isaac-Olivé (*), N. Ramírez-Durán, E. Morales-Avila, L. Aranda-Lara, and
P. Moreno-Pérez
Universidad Autónoma del Estado de México, Toluca, Estado de México, Mexico
e-mail: kisaaco@uaemex.mx
E. Olivé-Alvarez
Centro de Isótopos, La Habana, Cuba
A. E. Navarro-Frómeta
Universidad Tecnológica de Izúcar de Matamoros, Izúcar de Matamoros, Puebla, Mexico
H. Sandoval-Trujillo
Universidad Autónoma Metropolitana-Xochimilco, Ciudad de México, Mexico
Leobardo Manuel Gómez-Oliván (ed.), Non-Steroidal Anti-Inflammatory Drugs
in Water: Emerging Contaminants and Ecological Impact,
Hdb Env Chem (2020) 96: 83–104, DOI 10.1007/698_2020_543,
© Springer Nature Switzerland AG 2020, Published online: 2 July 2020
83