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45. Li Q, Wang P, Chen L, Gao H, Wu L (2016) Acute toxicity and histopathological effects of
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(18):18832–18841. https://doi.org/10.1007/s11356-016-7092-4
46. Fang T-H, Nan F-H, Chin T-S, Feng H-M (2012) The occurrence and distribution of pharmaceutical compounds in the effluents of a major sewage treatment plant in northern Taiwan and
the receiving coastal waters. Mar Pollut Bull 64(7):1435–1444. https://doi.org/10.1016/j.
marpolbul.2012.04.008
47. Wang J, Zhao S, Zhang M, He B (2018) Targeted eco-pharmacovigilance for ketoprofen in the
environment: need, strategy and challenge. Chemosphere 194:450–462. https://doi.org/10.
1016/j.chemosphere.2017.12.020
48. Rangasamy B, Hemalatha D, Shobana C, Nataraj B, Ramesh M (2018) Developmental toxicity
and biological responses of zebrafish (Danio rerio) exposed to anti-inflammatory drug
ketoprofen. Chemosphere 213:423–433. https://doi.org/10.1016/j.chemosphere.2018.09.013
49. Puljak L, Marin A, Vrdoljak D, Markotic F, Utrobicic A, Tugwell P (2017) Celecoxib for
osteoarthritis. Cochrane Database Syst Rev 5:CD009865. https://doi.org/10.1002/14651858.
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embryotoxicity assay for the high throughput screening of emerging contaminants in Mytilus
galloprovincialis. Mar Environ Res 99:1–8. https://doi.org/10.1016/j.marenvres.2014.05.007
35. Chae J, Seon M, Hwang Y, Min B, Kim S, Lee H, Park M (2015) Evaluation of developmental
toxicity and teratogenicity of diclofenac using Xenopus embryos. Chemosphere 120:52–58.
https://doi.org/10.1016/j.chemosphere.2014.05.063
36. Buser HR, Poiger T, Muller MD (1999) Occurrence and environmental behavior of the chiral
pharmaceutical drug ibuprofen in surface waters and in wastewater. Environ Sci Technol 33
(15):2529–2535. https://doi.org/10.1021/es981014w
37. Tran NH, Urase T, Ta TT (2014) A preliminary study on the occurrence of pharmaceutically
active compounds in hospital wastewater and surface water in Hanoi, Vietnam. Clean (Weinh)
42(3):267–275. https://doi.org/10.1002/clen.201300021
38. David A, Pancharatna K (2009) Developmental anomalies induced by a non-selective COX
inhibitor (ibuprofen) in zebrafish (Danio rerio). Environ Toxicol Pharmacol 27(3):390–395.
https://doi.org/10.1016/j.etap.2009.01.002
39. Veldhoen N, Skirrow RC, Brown LLY, Van Aggelen G, Helbing CC (2014) Effects of acute
exposure to the non-steroidal anti-inflammatory drug ibuprofen on the developing north
American bullfrog (Rana catesbeiana) tadpole. Environ Sci Technol 48(17):10439–10447.
https://doi.org/10.1021/es502539g
40. Richards SM, Cole SE (2006) A toxicity and hazard assessment of fourteen pharmaceuticals to
Xenopus laevis larvae. Ecotoxicology 15(8):647–656. https://doi.org/10.1007/s10646-0060102-4
41. Hernando MD, Heath E, Petrovic M, Barcelo D (2006) Trace-level determination of pharmaceutical residues by LC-MS/ MS in natural and treated waters. A pilot-survey study. Anal
Bioanal Chem 385:985–991. https://doi.org/10.1007/s00216-006-0394-5
42. Verenitch SS, Lowe CJ, Mazumder A (2006) Determination of acidic drugs and caffeine in
municipal wastewaters and receiving waters by gas chromatography-ion trap tandem mass
spectrometry. J Chromatogr A 1116(1–2):193–203. https://doi.org/10.1016/j.chroma.2006.03.
005
43. Xu C, Niu L, Guo H, Sun X, Chen L, Tu W et al (2019) Long-term exposure to the non-steroidal
anti-inflammatory drug (NSAID) naproxen causes thyroid disruption in zebrafish at environmentally relevant concentrations. Sci Total Environ 676:387–395. https://doi.org/10.1016/j.
scitotenv.2019.04.323
44. Sehonova P, Plhalova L, Blahova J, Doubkova V, Prokes M, Tichy F et al (2017) Toxicity of
naproxen sodium and its mixture with tramadol hydrochloride on fish early life stages.
Chemosphere 188:414–423. https://doi.org/10.1016/j.chemosphere.2017.08.151
45. Li Q, Wang P, Chen L, Gao H, Wu L (2016) Acute toxicity and histopathological effects of
naproxen in zebrafish (Danio rerio) early life stages. Environ Sci Pollut Res 23
(18):18832–18841. https://doi.org/10.1007/s11356-016-7092-4
46. Fang T-H, Nan F-H, Chin T-S, Feng H-M (2012) The occurrence and distribution of pharmaceutical compounds in the effluents of a major sewage treatment plant in northern Taiwan and
the receiving coastal waters. Mar Pollut Bull 64(7):1435–1444. https://doi.org/10.1016/j.
marpolbul.2012.04.008
47. Wang J, Zhao S, Zhang M, He B (2018) Targeted eco-pharmacovigilance for ketoprofen in the
environment: need, strategy and challenge. Chemosphere 194:450–462. https://doi.org/10.
1016/j.chemosphere.2017.12.020
48. Rangasamy B, Hemalatha D, Shobana C, Nataraj B, Ramesh M (2018) Developmental toxicity
and biological responses of zebrafish (Danio rerio) exposed to anti-inflammatory drug
ketoprofen. Chemosphere 213:423–433. https://doi.org/10.1016/j.chemosphere.2018.09.013
49. Puljak L, Marin A, Vrdoljak D, Markotic F, Utrobicic A, Tugwell P (2017) Celecoxib for
osteoarthritis. Cochrane Database Syst Rev 5:CD009865. https://doi.org/10.1002/14651858.
CD009865.pub2
128
I. Pérez-Alvarez et al.