References
1. Hignite C, Azarnoff DL (1977) Drugs and drug metabolites as environmental contaminants:
chlorophenoxyisobutyrate and salicylic acid in sewage water effluent. Life Sci 20(2):337–341.
https://doi.org/10.1016/0024-3205(77)90329-0
2. Barceló D, Daughton CG (2003) Emerging pollutants in water analysis. TrAC Trends Anal
Chem 22(10):711–732. https://doi.org/10.1016/S0165-9936(03)01106-3
3. Barceló D, López de Alda MJ (2008) Contaminación y calidad química del agua: el problema
de los contaminantes emergentes. Instituto de Investigaciones Químicas y Ambientales-CSIC,
Barcelona
4. Daughton CG, Ternes TA (1999) Pharmaceuticals and personal care products in the environment: agents of subtle change? Environ Health Perspect 107(Suppl):907–938
5. Bielen A, Šimatović A, Kosić-Vukšić J, Senta I, Ahel M, Babić S et al (2017) Negative
environmental impacts of antibiotic-contaminated effluents from pharmaceutical industries.
Water Res 126:79–87. https://doi.org/10.1016/j.watres.2017.09.019
6. Santos LHMLM, Araújo AN, Fachini A, Pena A, Delerue-Matos C, Montenegro MCBSM
(2010) Ecotoxicological aspects related to the presence of pharmaceuticals in the aquatic
environment. J Hazard Mater 175(1–3):45–95. https://doi.org/10.1016/j.jhazmat.2009.10.100
7. Santos LHMLM, Gros M, Rodriguez-Mozaz S, Delerue-Matos C, Pena A, Barceló D, Montenegro MCBSM (2013) Contribution of hospital effluents to the load of pharmaceuticals in urban
wastewaters: identification of ecologically relevant pharmaceuticals. Sci Total Environ
461–462:302–316. https://doi.org/10.1016/j.scitotenv.2013.04.077
8. Teixeira-Lemos E, Teixeira-Lemos LP, Oliveira J, Pais do Amaral J (2018) Pharmaceuticals in
the environment: focus on drinking-water. In: Reference module in chemistry, molecular
sciences and chemical engineering3rd edn, pp 1–11. https://doi.org/10.1016/B978-0-12409547-2.13941-1
9. Acevedo R (2014) Contaminantes emergentes en aguas: metabolitos de fármacos. Una revisión.
In: Universidad militar nueva granada, vol 10, pp 80–101
10. Calatayud S, Esplugues JV (2016) Chemistry, pharmacodynamics, and pharmacokinetics of
NSAIDs. In: NSAIDs and Aspirin, pp 3–16. https://doi.org/10.1007/978-3-319-33889-7_1
11. Vane JR, Botting RM (1998) Mechanism of action of nonsteroidal anti-inflammatory drugs.
Am J Med 104(3A):2S–8S. https://doi.org/10.1016/S0002-9343(97)00203-9
12. Lanas A (2016) NSAIDs and Aspirin: recent advances and implications for clinical management. https://books.google.com.mx/books?id¼riPqDAAAQBAJ
13. Melvin SD (2016) Oxidative stress, energy storage, and swimming performance of
Limnodynastes peronii tadpoles exposed to a sub-lethal pharmaceutical mixture throughout
development. Chemosphere 150:790–797. https://doi.org/10.1016/j.chemosphere.2015.09.034
14. Islas-Flores H, Gómez-Oliván LM, Galar-Martínez M, García-Medina S, Neri-Cruz N, DublánGarcía O (2014) Effect of ibuprofen exposure on blood, gill, liver, and brain on common carp
(Cyprinus carpio) using oxidative stress biomarkers. Environ Sci Pollut Res 21(7):5157–5166.
https://doi.org/10.1007/s11356-013-2477-0
15. André C, Gagné F (2017) Cumulative effects of ibuprofen and air emersion in zebra mussels
Dreissena polymorpha. Environ Toxicol Pharmacol 55:156–164. https://doi.org/10.1016/j.etap.
2017.08.016
16. Gómez-Oliván LM, Galar-Martínez M, García-Medina S, Valdés-Alanís A, Islas-Flores H,
Neri-Cruz N (2014) Genotoxic response and oxidative stress induced by diclofenac, ibuprofen
and naproxen in Daphnia magna. Drug Chem Toxicol 37(4):391–399. https://doi.org/10.3109/
01480545.2013.870191
17. Cardoso-Vera JD, Islas-Flores H, San Juan-Reyes N, Montero-Castro EI, Galar-Martínez M,
García-Medina S et al (2017) Comparative study of diclofenac-induced embryotoxicity and
teratogenesis in Xenopus laevis and Lithobates catesbeianus, using the frog embryo teratogenesis assay: Xenopus (FETAX). Sci Total Environ 574:467–475. https://doi.org/10.1016/j.
scitotenv.2016.09.095
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1. Hignite C, Azarnoff DL (1977) Drugs and drug metabolites as environmental contaminants:
chlorophenoxyisobutyrate and salicylic acid in sewage water effluent. Life Sci 20(2):337–341.
https://doi.org/10.1016/0024-3205(77)90329-0
2. Barceló D, Daughton CG (2003) Emerging pollutants in water analysis. TrAC Trends Anal
Chem 22(10):711–732. https://doi.org/10.1016/S0165-9936(03)01106-3
3. Barceló D, López de Alda MJ (2008) Contaminación y calidad química del agua: el problema
de los contaminantes emergentes. Instituto de Investigaciones Químicas y Ambientales-CSIC,
Barcelona
4. Daughton CG, Ternes TA (1999) Pharmaceuticals and personal care products in the environment: agents of subtle change? Environ Health Perspect 107(Suppl):907–938
5. Bielen A, Šimatović A, Kosić-Vukšić J, Senta I, Ahel M, Babić S et al (2017) Negative
environmental impacts of antibiotic-contaminated effluents from pharmaceutical industries.
Water Res 126:79–87. https://doi.org/10.1016/j.watres.2017.09.019
6. Santos LHMLM, Araújo AN, Fachini A, Pena A, Delerue-Matos C, Montenegro MCBSM
(2010) Ecotoxicological aspects related to the presence of pharmaceuticals in the aquatic
environment. J Hazard Mater 175(1–3):45–95. https://doi.org/10.1016/j.jhazmat.2009.10.100
7. Santos LHMLM, Gros M, Rodriguez-Mozaz S, Delerue-Matos C, Pena A, Barceló D, Montenegro MCBSM (2013) Contribution of hospital effluents to the load of pharmaceuticals in urban
wastewaters: identification of ecologically relevant pharmaceuticals. Sci Total Environ
461–462:302–316. https://doi.org/10.1016/j.scitotenv.2013.04.077
8. Teixeira-Lemos E, Teixeira-Lemos LP, Oliveira J, Pais do Amaral J (2018) Pharmaceuticals in
the environment: focus on drinking-water. In: Reference module in chemistry, molecular
sciences and chemical engineering3rd edn, pp 1–11. https://doi.org/10.1016/B978-0-12409547-2.13941-1
9. Acevedo R (2014) Contaminantes emergentes en aguas: metabolitos de fármacos. Una revisión.
In: Universidad militar nueva granada, vol 10, pp 80–101
10. Calatayud S, Esplugues JV (2016) Chemistry, pharmacodynamics, and pharmacokinetics of
NSAIDs. In: NSAIDs and Aspirin, pp 3–16. https://doi.org/10.1007/978-3-319-33889-7_1
11. Vane JR, Botting RM (1998) Mechanism of action of nonsteroidal anti-inflammatory drugs.
Am J Med 104(3A):2S–8S. https://doi.org/10.1016/S0002-9343(97)00203-9
12. Lanas A (2016) NSAIDs and Aspirin: recent advances and implications for clinical management. https://books.google.com.mx/books?id¼riPqDAAAQBAJ
13. Melvin SD (2016) Oxidative stress, energy storage, and swimming performance of
Limnodynastes peronii tadpoles exposed to a sub-lethal pharmaceutical mixture throughout
development. Chemosphere 150:790–797. https://doi.org/10.1016/j.chemosphere.2015.09.034
14. Islas-Flores H, Gómez-Oliván LM, Galar-Martínez M, García-Medina S, Neri-Cruz N, DublánGarcía O (2014) Effect of ibuprofen exposure on blood, gill, liver, and brain on common carp
(Cyprinus carpio) using oxidative stress biomarkers. Environ Sci Pollut Res 21(7):5157–5166.
https://doi.org/10.1007/s11356-013-2477-0
15. André C, Gagné F (2017) Cumulative effects of ibuprofen and air emersion in zebra mussels
Dreissena polymorpha. Environ Toxicol Pharmacol 55:156–164. https://doi.org/10.1016/j.etap.
2017.08.016
16. Gómez-Oliván LM, Galar-Martínez M, García-Medina S, Valdés-Alanís A, Islas-Flores H,
Neri-Cruz N (2014) Genotoxic response and oxidative stress induced by diclofenac, ibuprofen
and naproxen in Daphnia magna. Drug Chem Toxicol 37(4):391–399. https://doi.org/10.3109/
01480545.2013.870191
17. Cardoso-Vera JD, Islas-Flores H, San Juan-Reyes N, Montero-Castro EI, Galar-Martínez M,
García-Medina S et al (2017) Comparative study of diclofenac-induced embryotoxicity and
teratogenesis in Xenopus laevis and Lithobates catesbeianus, using the frog embryo teratogenesis assay: Xenopus (FETAX). Sci Total Environ 574:467–475. https://doi.org/10.1016/j.
scitotenv.2016.09.095
126
I. Pérez-Alvarez et al.