Teratogenesis and Embryotoxicity Induced
by Non-steroidal Anti-Inflammatory Drugs
in Aquatic Organisms
Itzayana Pérez-Alvarez, Hariz Islas-Flores,
Leobardo Manuel Gómez-Oliván, and Octavio Dublán García
Contents
1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 116
1.1 Diclofenac . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 118
1.2 Ibuprofen . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 121
1.3 Naproxen . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 122
1.4 Ketoprofen . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . 123
1.5 Celecoxib . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 124
1.6 Paracetamol . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . 124
1.7 Acetylsalicylic Acid . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 124
2 Conclusions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 125
References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 126
Abstract The continuous elimination of pharmaceutical products to water sources
has become a worldwide problem and has been getting considerable attention due to
the effects that this compounds have induced in aquatic organisms, specifically
non-steroidal anti-inflammatory drugs (NSAIDs), one of the most representative
group of medications and the most consumed around the world, highlighting the
teratogenic and embryotoxic effects induced by NSAIDs on early life stages of
different organisms being this the most vulnerable stages in development; the main
representants of NSAID group (diclofenac, ibuprofen, naproxen, ketoprofen, paracetamol, acetylsalicylic acid) have induced adverse embryonic effects, which can be
consider for the development of strategies for an appropriate disposal of pharmaceutical residues, as well as establish maximum permissible limits for its emission to
the environment.
I. Pérez-Alvarez, H. Islas-Flores (*), L. M. Gómez-Oliván, and O. D. García
Laboratorio de Toxicología Ambiental, Facultad de Química, Universidad Autónoma del
Estado de México, Toluca, Estado de México, Mexico
e-mail: hislasf@uaemex.mx
Leobardo Manuel Gómez-Oliván (ed.), Non-Steroidal Anti-Inflammatory Drugs
in Water: Emerging Contaminants and Ecological Impact,
Hdb Env Chem (2020) 96: 115–130, DOI 10.1007/698_2020_545,
© Springer Nature Switzerland AG 2020, Published online: 22 June 2020
115
by Non-steroidal Anti-Inflammatory Drugs
in Aquatic Organisms
Itzayana Pérez-Alvarez, Hariz Islas-Flores,
Leobardo Manuel Gómez-Oliván, and Octavio Dublán García
Contents
1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 116
1.1 Diclofenac . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 118
1.2 Ibuprofen . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 121
1.3 Naproxen . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 122
1.4 Ketoprofen . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . 123
1.5 Celecoxib . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 124
1.6 Paracetamol . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . 124
1.7 Acetylsalicylic Acid . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 124
2 Conclusions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 125
References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 126
Abstract The continuous elimination of pharmaceutical products to water sources
has become a worldwide problem and has been getting considerable attention due to
the effects that this compounds have induced in aquatic organisms, specifically
non-steroidal anti-inflammatory drugs (NSAIDs), one of the most representative
group of medications and the most consumed around the world, highlighting the
teratogenic and embryotoxic effects induced by NSAIDs on early life stages of
different organisms being this the most vulnerable stages in development; the main
representants of NSAID group (diclofenac, ibuprofen, naproxen, ketoprofen, paracetamol, acetylsalicylic acid) have induced adverse embryonic effects, which can be
consider for the development of strategies for an appropriate disposal of pharmaceutical residues, as well as establish maximum permissible limits for its emission to
the environment.
I. Pérez-Alvarez, H. Islas-Flores (*), L. M. Gómez-Oliván, and O. D. García
Laboratorio de Toxicología Ambiental, Facultad de Química, Universidad Autónoma del
Estado de México, Toluca, Estado de México, Mexico
e-mail: hislasf@uaemex.mx
Leobardo Manuel Gómez-Oliván (ed.), Non-Steroidal Anti-Inflammatory Drugs
in Water: Emerging Contaminants and Ecological Impact,
Hdb Env Chem (2020) 96: 115–130, DOI 10.1007/698_2020_545,
© Springer Nature Switzerland AG 2020, Published online: 22 June 2020
115