DNA Alterations and Cellular Damage
Induced by Non-steroidal
Anti-inflammatories on Different Species
of Fish
Nely SanJuan-Reyes, Leobardo Manuel Gómez-Oliván, Ricardo PérezPastén Borja, Hariz Islas-Flores, Marcela Galar-Martínez,
and Sandra García-Medina
Contents
1 Non-steroidal Anti-inflammatory Drugs . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 106
2 Oxidative Stress, Geno- and Cytotoxicity . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 107
3 Biomarkers and Bioindicators . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 108
4 Studies of Oxidative Damage on Aquatic Organisms . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 109
5 Conclusions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 109
References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 112
Abstract Non-steroidal anti-inflammatory drugs (NSAIDs) are a group of drugs
used to reduce inflammation, pain, and fever by inhibiting the enzyme cyclooxygenase (COX 1 and COX 2). These drugs have been positioned among the most
consumed worldwide. After their biotransformation in the body, they are eliminated
as metabolites, and also in the environment they can undergo transformations,
N. SanJuan-Reyes (*) and R. Pérez-Pastén Borja
Laboratory of Molecular Toxicology, Escuela Nacional de Ciencias Biológicas, Instituto
Politécnico Nacional, Ciudad de México, Mexico
e-mail: nesajure0905@gmail.com
L. M. Gómez-Oliván and H. Islas-Flores
Laboratory of Environmental Toxicology, Facultad de Química, Universidad Autónoma del
Estado de México, Toluca, Mexico
M. Galar-Martínez and S. García-Medina
Laboratory of Aquatic Toxicology, Escuela Nacional de Ciencias Biológicas, Instituto
Politécnico Nacional, Ciudad de México, Mexico
Leobardo Manuel Gómez-Oliván (ed.), Non-Steroidal Anti-Inflammatory Drugs
in Water: Emerging Contaminants and Ecological Impact,
Hdb Env Chem (2020) 96: 105–114, DOI 10.1007/698_2020_544,
© Springer Nature Switzerland AG 2020, Published online: 22 June 2020
105
Induced by Non-steroidal
Anti-inflammatories on Different Species
of Fish
Nely SanJuan-Reyes, Leobardo Manuel Gómez-Oliván, Ricardo PérezPastén Borja, Hariz Islas-Flores, Marcela Galar-Martínez,
and Sandra García-Medina
Contents
1 Non-steroidal Anti-inflammatory Drugs . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 106
2 Oxidative Stress, Geno- and Cytotoxicity . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 107
3 Biomarkers and Bioindicators . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 108
4 Studies of Oxidative Damage on Aquatic Organisms . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 109
5 Conclusions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 109
References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 112
Abstract Non-steroidal anti-inflammatory drugs (NSAIDs) are a group of drugs
used to reduce inflammation, pain, and fever by inhibiting the enzyme cyclooxygenase (COX 1 and COX 2). These drugs have been positioned among the most
consumed worldwide. After their biotransformation in the body, they are eliminated
as metabolites, and also in the environment they can undergo transformations,
N. SanJuan-Reyes (*) and R. Pérez-Pastén Borja
Laboratory of Molecular Toxicology, Escuela Nacional de Ciencias Biológicas, Instituto
Politécnico Nacional, Ciudad de México, Mexico
e-mail: nesajure0905@gmail.com
L. M. Gómez-Oliván and H. Islas-Flores
Laboratory of Environmental Toxicology, Facultad de Química, Universidad Autónoma del
Estado de México, Toluca, Mexico
M. Galar-Martínez and S. García-Medina
Laboratory of Aquatic Toxicology, Escuela Nacional de Ciencias Biológicas, Instituto
Politécnico Nacional, Ciudad de México, Mexico
Leobardo Manuel Gómez-Oliván (ed.), Non-Steroidal Anti-Inflammatory Drugs
in Water: Emerging Contaminants and Ecological Impact,
Hdb Env Chem (2020) 96: 105–114, DOI 10.1007/698_2020_544,
© Springer Nature Switzerland AG 2020, Published online: 22 June 2020
105