8 Bioinformatics
Bioinformatics is an important part of modern biotechnology that combines biology
and information technology. Bioinformatics seek information and keep all the
biological data, helping to investigate and decide relationships among organic
molecules, such as macromolecular sequences, structures, biochemical pathways,
and expression profiles. Biology and computer systems are running parallel, which
might be collectively respecting, supporting, and influencing each other and synergistically merging as greater than ever (Fulekar 2008). Enormous amounts of data
and statistics from biology, especially within the form of DNA, RNA, and protein
sequences, are slowly accumulating, thus placing heavy demand on computers and
scientists. Bioinformatics has also led to finding possible cures for detoxification of
the environment. Scientists expert in analyzing biological data can use the computational tools to solve the problems of bioremediation (Westhead et al. 2003). The
important branches of bioinformatics are genomics, transcriptomics, proteomics,
organic databases, molecular phylogenetics, and microarray informatics, which are
crucial in understanding bioinformatics. These bioinformatics-associated tools are
very imporant for bioremediation of hazardous wastes.
8.1 Bioinformatics in Bioremediation-MetaRouter
MetaRouter is an application for laboratories working in bioremediation that need to
maintain public and private data, linked internally and with external databases, and
to extract new information from it. The system has a very versatile open and modular
architecture adaptable to different customers. It is a multiplatform program,
implemented in Postgre SQL (standard language for relational databases) and
using SRS as an indexing system (used to connect and query Molecular Biology
databases). MetaRouter uses a client/server architecture that allows the program to
run on the user station or on the company server, so it can be accessed from any place
in a secure way just by having a web browser.
Bioinformatics will facilitate and quicken the analysis of cellular processes and
also the investigation of the cellular mechanisms used to treat wastes. Coming
decades will yield greater understanding of molecular mechanisms and cellular
metabolism coupled with bioinformatics.
8.2 Bioinformatics Resources
Many bioinformatic resources are available today exclusively for bioremediation
studies and analyses. In 1955 University of Minnesota Biocatalysis/Biodegradation
Database (UM-BBD, http://umbbd.msi.umn.edu/) was developed and has been
18 Molecular Technologies for Assessment of Bioremediation and. . .
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