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Ribas A (2010) Evidence of RNAi in humans from systemically administered siRNA via
targeted nanoparticles. Nature 464:1067–1070
43. Gonzalez H, Hwang SJ, Davis ME (1999) New class of polymers for the delivery of
macromolecular therapeutics. Bioconjug Chem 10:1068–1074
44. Koopmans C, Ritter H (2008) Formation of physical hydrogels via hostÀguest interactions of
β-cyclodextrin polymers and copolymers bearing adamantyl groups. Macromolecules
41:7418–7422
45. Yan HJ, He LL, Ma C, Li JS, Yang JF, Yang RH, Tan WH (2014) Poly β-cyclodextrin
inclusion-induced formation of two-photon fluorescent nanomicelles for biomedical imaging.
Chem Commun 50:8398–8840
46. Yan HJ, He LL, Zhao W-J, Li JS, Xiao Y, Yang RH, Tan WH (2014) Poly β-Cyclodextrin/
TPdye Nanomicelle-based two-photon nanoprobe for caspase-3 activation imaging in live
cells and tissues. Anal Chem 86:11440–11450
47. Harada A, Kamachi M (1990) Complex formation between poly(ethylene glycol) and αcyclodextrin. Macromolecules 23:2821–2823
48. Harada A, Takashima Y, Yamaguchi H (2009) Cyclodextrin-based supramolecular polymers.
Chem Soc Rev 38:875–882
49. Harada A, Okada M (1999) Complex formation between hydrophobic polymers and methylated cyclodextrins. Oligo(ethylene) and poly(propylene). Polym J 31:1095–1098
50. Kawaguchi Y, Nishiyama T, Okada M, Kamachi M, Harada A (2000) Complex formation of
poly(ε-caprolactone) with cyclodextrins. Macromolecules 33:4472–4477
51. Harada A, Kamachi M (1990) Complex formation between cyclodextrin and poly(propylene
glycol). J Chem Soc Chem Commun:1322–1323
52. Harada A, Suzuki S, Okada M, Kamachi M (1996) Preparation and characterization of
inclusion complexes of polyisobutylene with cyclodextrins. Macromolecules 29:5611–5614
53. Harada A, Li J, Kamachi M (1993) Cyclodextrin-based polymeric materials: synthesis,
properties, and pharmaceutical/biomedical applications. Chem Lett 22:237–240
54. Harada A, Li J, Suzuki S, Okada M, Kamachi M (1993) Complex formation between
polyisobutylene and cyclodextrins: inversion of chain-length selectivity between.beta.-cyclodextrin and.gamma.-cyclodextrin. Macromolecules 26:5267–5268
55. Okumura H, Kawaguchi Y, Harada A (2001) Preparation and characterization of inclusion
complexes of poly(dimethylsiloxane)s with cyclodextrins. Macromolecules 34:6338–6343
56. Okumura H, Kawaguchi Y, Harada A (2003) Preparation and characterization of the inclusion
complexes of poly(dimethylsilane)s with cyclodextrins. Macromolecules 36:6422–6429
57. Tamura A, Tokunaga M, Iwasaki Y, Yui N (2014) Spontaneous assembly into pseudopolyrotaxane between cyclodextrins and biodegradable polyphosphoester ionomers. Macromol Chem Phys 215:648–653
58. Tamura A, Yui N (2013) A supramolecular endosomal escape approach for enhancing gene
silencing of siRNA using acid-degradable cationic polyrotaxanes. J Mater Chem B 1:3535–3544
59. Tachaboonyakiat W, Furubayashi T, Katoh M, Ooya T, Yui N (2004) Novel biodegradable
cholesterol-modified polyrotaxane hydrogels for cartilage regeneration. J Biomater Sci Polym
Edn 15:1389–1404
60. Choi HS, Ooya T, Sasaki S, Yui N, Ohya Y, Nakai T, Ouchi T (2003) Preparation and
characterization of polypseudorotaxanes based on biodegradable poly(L-lactide)/poly(ethylene glycol) triblock copolymers. Macromolecules 36:9313–9318
61. Ooya T, Arizono K, Yui N (2000) Synthesis and characterization of an oligopeptide-terminated
polyrotaxane as a drug carrier. Polym Adv Technol 11:642–651
62. Eguchi M, Ooya T, Yui N (2004) Controlling the mechanism of trypsin inhibition by the
number of α-cyclodextrins in carboxyethylester-polyrotaxanes. J Control Release 96:301–307
63. Ooya T, Eguchi M, Ozaki A, Yui N (2002) Carboxyethylester-polyrotaxanes as a new calcium
chilating polymer: synthesis, calcium binding and mechanism of trypsin inhibition. Int J
Pharm 242:47–54
556
Y.-H. Liu et al.
Ribas A (2010) Evidence of RNAi in humans from systemically administered siRNA via
targeted nanoparticles. Nature 464:1067–1070
43. Gonzalez H, Hwang SJ, Davis ME (1999) New class of polymers for the delivery of
macromolecular therapeutics. Bioconjug Chem 10:1068–1074
44. Koopmans C, Ritter H (2008) Formation of physical hydrogels via hostÀguest interactions of
β-cyclodextrin polymers and copolymers bearing adamantyl groups. Macromolecules
41:7418–7422
45. Yan HJ, He LL, Ma C, Li JS, Yang JF, Yang RH, Tan WH (2014) Poly β-cyclodextrin
inclusion-induced formation of two-photon fluorescent nanomicelles for biomedical imaging.
Chem Commun 50:8398–8840
46. Yan HJ, He LL, Zhao W-J, Li JS, Xiao Y, Yang RH, Tan WH (2014) Poly β-Cyclodextrin/
TPdye Nanomicelle-based two-photon nanoprobe for caspase-3 activation imaging in live
cells and tissues. Anal Chem 86:11440–11450
47. Harada A, Kamachi M (1990) Complex formation between poly(ethylene glycol) and αcyclodextrin. Macromolecules 23:2821–2823
48. Harada A, Takashima Y, Yamaguchi H (2009) Cyclodextrin-based supramolecular polymers.
Chem Soc Rev 38:875–882
49. Harada A, Okada M (1999) Complex formation between hydrophobic polymers and methylated cyclodextrins. Oligo(ethylene) and poly(propylene). Polym J 31:1095–1098
50. Kawaguchi Y, Nishiyama T, Okada M, Kamachi M, Harada A (2000) Complex formation of
poly(ε-caprolactone) with cyclodextrins. Macromolecules 33:4472–4477
51. Harada A, Kamachi M (1990) Complex formation between cyclodextrin and poly(propylene
glycol). J Chem Soc Chem Commun:1322–1323
52. Harada A, Suzuki S, Okada M, Kamachi M (1996) Preparation and characterization of
inclusion complexes of polyisobutylene with cyclodextrins. Macromolecules 29:5611–5614
53. Harada A, Li J, Kamachi M (1993) Cyclodextrin-based polymeric materials: synthesis,
properties, and pharmaceutical/biomedical applications. Chem Lett 22:237–240
54. Harada A, Li J, Suzuki S, Okada M, Kamachi M (1993) Complex formation between
polyisobutylene and cyclodextrins: inversion of chain-length selectivity between.beta.-cyclodextrin and.gamma.-cyclodextrin. Macromolecules 26:5267–5268
55. Okumura H, Kawaguchi Y, Harada A (2001) Preparation and characterization of inclusion
complexes of poly(dimethylsiloxane)s with cyclodextrins. Macromolecules 34:6338–6343
56. Okumura H, Kawaguchi Y, Harada A (2003) Preparation and characterization of the inclusion
complexes of poly(dimethylsilane)s with cyclodextrins. Macromolecules 36:6422–6429
57. Tamura A, Tokunaga M, Iwasaki Y, Yui N (2014) Spontaneous assembly into pseudopolyrotaxane between cyclodextrins and biodegradable polyphosphoester ionomers. Macromol Chem Phys 215:648–653
58. Tamura A, Yui N (2013) A supramolecular endosomal escape approach for enhancing gene
silencing of siRNA using acid-degradable cationic polyrotaxanes. J Mater Chem B 1:3535–3544
59. Tachaboonyakiat W, Furubayashi T, Katoh M, Ooya T, Yui N (2004) Novel biodegradable
cholesterol-modified polyrotaxane hydrogels for cartilage regeneration. J Biomater Sci Polym
Edn 15:1389–1404
60. Choi HS, Ooya T, Sasaki S, Yui N, Ohya Y, Nakai T, Ouchi T (2003) Preparation and
characterization of polypseudorotaxanes based on biodegradable poly(L-lactide)/poly(ethylene glycol) triblock copolymers. Macromolecules 36:9313–9318
61. Ooya T, Arizono K, Yui N (2000) Synthesis and characterization of an oligopeptide-terminated
polyrotaxane as a drug carrier. Polym Adv Technol 11:642–651
62. Eguchi M, Ooya T, Yui N (2004) Controlling the mechanism of trypsin inhibition by the
number of α-cyclodextrins in carboxyethylester-polyrotaxanes. J Control Release 96:301–307
63. Ooya T, Eguchi M, Ozaki A, Yui N (2002) Carboxyethylester-polyrotaxanes as a new calcium
chilating polymer: synthesis, calcium binding and mechanism of trypsin inhibition. Int J
Pharm 242:47–54
556
Y.-H. Liu et al.