CD hydrogels combine the advantages of both gels’ micro-fluidity and elasticity,
and CDs’ good water solubility, biocompatibility, and specific bonding ability have
been applied as biosensors, detection sensors, adsorption removal sponges, and
smart materials. Although CD gels play a pivotal role in numerous fields, they are
also facing enormous challenges. For example, in the field of drug delivery, how to
increase the loading rate of drugs on CD gels, prevent the drug leakage during the
delivery process, and achieve more effective killing of diseased cells and zero
damage to normal cells still remain a major difficulty. In the field of chemical
detection, how to further reduce detection limit of small molecules such as sugars,
herbicides, insecticides, etc. and achieve rapid visual inspection also need to be
further investigated. In the field of environmental protection, how to achieve more
rapid and effective removal of pollutants and provide effective means for the control
of water, air, and soil pollution are still urgent. In the field of new materials, how to
fabricate smart CD hydrogel material is also a great challenge. With the fast
improvement of basic research, it is hopeful that supramolecular CD gels will play
an invaluable role in the future.
Acknowledgments We thank NNSFC (21432004, 21672113, 21772099, 21861132001) for the
financial support.
References
1. Lai W-F, Rogach AL, Wong W-T (2017) Chemistry and engineering of cyclodextrins for
molecular imaging. Chem Soc Rev 46:6379–6419
2. Prochowicz D, Kornowicz A, Lewiński J (2017) Interactions of native cyclodextrins with metal
ions and inorganic nanoparticles: fertile landscape for chemistry and materials science.
Chem Rev 117:13461–13501
3. Varan G, Varan C, Erdoğar N, Hıncal AA, Bilensoy E (2017) Amphiphilic cyclodextrin
nanoparticles. Int J Pharm 531:457–469
4. Harada A, Nakahata M, Takashima Y (2017) Supramolecular polymeric materials containing
cyclodextrins. Chem Pharm Bull 65:330–335
5. Kolesnichenko IV, Anslyn EV (2017) Practical applications of supramolecular chemistry.
Chem Soc Rev 46:2385–2390
6. Liu B-W, Zhou H, Zhou S-T, Yuan J-Y (2015) Macromolecules based on recognition between
cyclodextrin and guest molecules: synthesis, properties and functions. Eur Polym J 65:63–81
7. Schmidt BVKJ, Barner-Kowollik C (2017) Dynamic macromolecular material design—the
versatility of cyclodextrin-based host–guest chemistry. Angew Chem Int Ed 56:8350–8369
8. Szente L, Fenyvesi É (2017) Cyclodextrin-lipid complexes: cavity size matters. Struct Chem
28:479–492
9. Hu X, Gao J, Luo Y, Wei T, Dong Y, Chen G, Chen H (2017) One-pot multicomponent
synthesis of glycopolymers through a combination of host–guest interaction, thiol-ene, and
copper-catalyzed click reaction in water. Macromol Rapid Commun 38:1700434–1700441
10. Ma X, Zhou N, Zhang T, Hu W, Gu N (2017) Self-healing pH-sensitive poly[(methyl vinyl
ether)-alt-(maleic acid)]-based supramolecular hydrogels formed by inclusion complexation
between cyclodextrin and adamantane. Mater Sci Eng C 73:357–365
11. Wang J, Li Q, Yi S, Chen X (2017) Visible-light/temperature dual-responsive hydrogel
constructed by α-cyclodextrin and an azobenzene linked surfactant. Soft Matter 13:6490–6498
17 Cyclodextrin-Based Supramolecular Hydrogel
505
and CDs’ good water solubility, biocompatibility, and specific bonding ability have
been applied as biosensors, detection sensors, adsorption removal sponges, and
smart materials. Although CD gels play a pivotal role in numerous fields, they are
also facing enormous challenges. For example, in the field of drug delivery, how to
increase the loading rate of drugs on CD gels, prevent the drug leakage during the
delivery process, and achieve more effective killing of diseased cells and zero
damage to normal cells still remain a major difficulty. In the field of chemical
detection, how to further reduce detection limit of small molecules such as sugars,
herbicides, insecticides, etc. and achieve rapid visual inspection also need to be
further investigated. In the field of environmental protection, how to achieve more
rapid and effective removal of pollutants and provide effective means for the control
of water, air, and soil pollution are still urgent. In the field of new materials, how to
fabricate smart CD hydrogel material is also a great challenge. With the fast
improvement of basic research, it is hopeful that supramolecular CD gels will play
an invaluable role in the future.
Acknowledgments We thank NNSFC (21432004, 21672113, 21772099, 21861132001) for the
financial support.
References
1. Lai W-F, Rogach AL, Wong W-T (2017) Chemistry and engineering of cyclodextrins for
molecular imaging. Chem Soc Rev 46:6379–6419
2. Prochowicz D, Kornowicz A, Lewiński J (2017) Interactions of native cyclodextrins with metal
ions and inorganic nanoparticles: fertile landscape for chemistry and materials science.
Chem Rev 117:13461–13501
3. Varan G, Varan C, Erdoğar N, Hıncal AA, Bilensoy E (2017) Amphiphilic cyclodextrin
nanoparticles. Int J Pharm 531:457–469
4. Harada A, Nakahata M, Takashima Y (2017) Supramolecular polymeric materials containing
cyclodextrins. Chem Pharm Bull 65:330–335
5. Kolesnichenko IV, Anslyn EV (2017) Practical applications of supramolecular chemistry.
Chem Soc Rev 46:2385–2390
6. Liu B-W, Zhou H, Zhou S-T, Yuan J-Y (2015) Macromolecules based on recognition between
cyclodextrin and guest molecules: synthesis, properties and functions. Eur Polym J 65:63–81
7. Schmidt BVKJ, Barner-Kowollik C (2017) Dynamic macromolecular material design—the
versatility of cyclodextrin-based host–guest chemistry. Angew Chem Int Ed 56:8350–8369
8. Szente L, Fenyvesi É (2017) Cyclodextrin-lipid complexes: cavity size matters. Struct Chem
28:479–492
9. Hu X, Gao J, Luo Y, Wei T, Dong Y, Chen G, Chen H (2017) One-pot multicomponent
synthesis of glycopolymers through a combination of host–guest interaction, thiol-ene, and
copper-catalyzed click reaction in water. Macromol Rapid Commun 38:1700434–1700441
10. Ma X, Zhou N, Zhang T, Hu W, Gu N (2017) Self-healing pH-sensitive poly[(methyl vinyl
ether)-alt-(maleic acid)]-based supramolecular hydrogels formed by inclusion complexation
between cyclodextrin and adamantane. Mater Sci Eng C 73:357–365
11. Wang J, Li Q, Yi S, Chen X (2017) Visible-light/temperature dual-responsive hydrogel
constructed by α-cyclodextrin and an azobenzene linked surfactant. Soft Matter 13:6490–6498
17 Cyclodextrin-Based Supramolecular Hydrogel
505