sugars and CDs. This discovery could also be applicable for functionalization on the
primary rim of CDs, resulting in the introduction of two or more different functions
on the primary-rim regioselectively [11, 12] (Scheme 3).
Furthermore, they found that the double debenzylation reaction occurred by a
stepwise process, which meant it was possible to stop the reaction at the monohydroxy cyclodextrin (23) stage if the reaction time was controlled well. After being
treated with DIBAL-H, 23 would give cyclodextrin diol 25 with an excellent yield,
Fig. 1 First reference to a
capped cyclodextrin [7]
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J. Liu et al.
primary rim of CDs, resulting in the introduction of two or more different functions
on the primary-rim regioselectively [11, 12] (Scheme 3).
Furthermore, they found that the double debenzylation reaction occurred by a
stepwise process, which meant it was possible to stop the reaction at the monohydroxy cyclodextrin (23) stage if the reaction time was controlled well. After being
treated with DIBAL-H, 23 would give cyclodextrin diol 25 with an excellent yield,
Fig. 1 First reference to a
capped cyclodextrin [7]
388
J. Liu et al.