9.3
Conclusion
In this chapter, we have described the recent advances of supermolecular
recognization-based biosensors and briefly summarized their applications for the
monitoring of metal ions, nucleic acids, antigens, proteins, and small molecules, by
means of several inspiring examples. These sensing strategies involving supermolecular recognization can offer some new approaches for the design of advanced
biosensors. Moreover, the newly emerging host molecules (e.g., pillararene) present
a huge potential in the development of easy-to-use biosensors. Thus, with the rapid
development of supermolecular chemistry, we believe that more biosensors will be
developed, which will play a greater role in clinical diagnosis, food safety, and
environmental monitoring.
Acknowledgments This work was financially supported by the National Natural Science Foundation of China (No. 21703199 and 21773203) and a project funded by the Priority Academic
Program Development of Jiangsu Higher Education Institutions.
References
1. Huang FH, Anslyn EV (2015) Introduction: supramolecular chemistry. Chem Rev 115:6999–7000
2. Li SL, Xiao TX, Lin C, Wang LY (2012) Advanced supramolecular polymers constructed by
orthogonal self-assembly. Chem Soc Rev 41:5950–5968
3. Agasti SS, Liong M, Tassa C, Chung HJ, Shaw SY, Lee H, Weissleder R (2012) Supramolecular
host-guest interaction for labeling and detection of cellular biomarkers. Angew Chem Int Ed
51:450–454
4. Beatty MA, Borges-Gonzalez J, Sinclair NJ, Pye AT, Hof F (2018) Analyte-driven disassembly
and turn-on fluorescent sensing in competitive biological media. J Am Chem Soc 140:3500–3504
5. Webber MJ, Langer R (2017) Drug delivery by supramolecular design. Chem Soc Rev
46:6600–6620
6. Ellis RJ, Meridiano Y, Muller J, Berthon L, Guilbaud P, Zorz N, Antonio MR, Demars T, Zemb
T (2014) Complexation-induced supramolecular assembly drives metal-ion extraction. Chem
Eur J 20:12796–12807
7. Bockus AT, Smith LC, Grice AG, Ali OA, Young CC, Mobley W, Leek A, Roberts JL,
Vinciguerra B, Isaacs L, Urbach AR (2016) Cucurbit[7]uril-tetramethylrhodamine conjugate
for direct sensing and cellular imaging. J Am Chem Soc 138:16549–16552
8. Guo YJ, Guo SJ, Ren JT, Zhai YM, Dong SJ, Wang EK (2010) Cyclodextrin functionalized
graphene nanosheets with high supramolecular recognition capability: synthesis and host-guest
inclusion for enhanced electrochemical performance. ACS Nano 4:4001–4010
9. Ul Alam A, Qin YH, Catalano M, Wang LH, Kim MJ, Howlader MMR, Hu NX, Deen MJ
(2018) Tailoring MWCNTs and beta-cyclodextrin for sensitive detection of acetaminophen and
estrogen. ACS Appl Mater Interfaces 10:21411–21427
10. Liu ZG, Zhang A, Guo YJ, Dong C (2014) Electrochemical sensor for ultrasensitive determination of isoquercitrin and baicalin based on DM-beta-cyclodextrin functionalized graphene
nanosheets. Biosens Bioelectron 58:242–248
11. Yang L, Zhao H, Li YC, Li CP (2015) Electrochemical simultaneous determination of hydroquinone and p-nitrophenol based on host-guest molecular recognition capability of dual betacyclodextrin functionalized Au@graphene nanohybrids. Sensors Actuators B Chem 207:1–8
9 Preparation of Biosensor Based on Supermolecular Recognization
247
Conclusion
In this chapter, we have described the recent advances of supermolecular
recognization-based biosensors and briefly summarized their applications for the
monitoring of metal ions, nucleic acids, antigens, proteins, and small molecules, by
means of several inspiring examples. These sensing strategies involving supermolecular recognization can offer some new approaches for the design of advanced
biosensors. Moreover, the newly emerging host molecules (e.g., pillararene) present
a huge potential in the development of easy-to-use biosensors. Thus, with the rapid
development of supermolecular chemistry, we believe that more biosensors will be
developed, which will play a greater role in clinical diagnosis, food safety, and
environmental monitoring.
Acknowledgments This work was financially supported by the National Natural Science Foundation of China (No. 21703199 and 21773203) and a project funded by the Priority Academic
Program Development of Jiangsu Higher Education Institutions.
References
1. Huang FH, Anslyn EV (2015) Introduction: supramolecular chemistry. Chem Rev 115:6999–7000
2. Li SL, Xiao TX, Lin C, Wang LY (2012) Advanced supramolecular polymers constructed by
orthogonal self-assembly. Chem Soc Rev 41:5950–5968
3. Agasti SS, Liong M, Tassa C, Chung HJ, Shaw SY, Lee H, Weissleder R (2012) Supramolecular
host-guest interaction for labeling and detection of cellular biomarkers. Angew Chem Int Ed
51:450–454
4. Beatty MA, Borges-Gonzalez J, Sinclair NJ, Pye AT, Hof F (2018) Analyte-driven disassembly
and turn-on fluorescent sensing in competitive biological media. J Am Chem Soc 140:3500–3504
5. Webber MJ, Langer R (2017) Drug delivery by supramolecular design. Chem Soc Rev
46:6600–6620
6. Ellis RJ, Meridiano Y, Muller J, Berthon L, Guilbaud P, Zorz N, Antonio MR, Demars T, Zemb
T (2014) Complexation-induced supramolecular assembly drives metal-ion extraction. Chem
Eur J 20:12796–12807
7. Bockus AT, Smith LC, Grice AG, Ali OA, Young CC, Mobley W, Leek A, Roberts JL,
Vinciguerra B, Isaacs L, Urbach AR (2016) Cucurbit[7]uril-tetramethylrhodamine conjugate
for direct sensing and cellular imaging. J Am Chem Soc 138:16549–16552
8. Guo YJ, Guo SJ, Ren JT, Zhai YM, Dong SJ, Wang EK (2010) Cyclodextrin functionalized
graphene nanosheets with high supramolecular recognition capability: synthesis and host-guest
inclusion for enhanced electrochemical performance. ACS Nano 4:4001–4010
9. Ul Alam A, Qin YH, Catalano M, Wang LH, Kim MJ, Howlader MMR, Hu NX, Deen MJ
(2018) Tailoring MWCNTs and beta-cyclodextrin for sensitive detection of acetaminophen and
estrogen. ACS Appl Mater Interfaces 10:21411–21427
10. Liu ZG, Zhang A, Guo YJ, Dong C (2014) Electrochemical sensor for ultrasensitive determination of isoquercitrin and baicalin based on DM-beta-cyclodextrin functionalized graphene
nanosheets. Biosens Bioelectron 58:242–248
11. Yang L, Zhao H, Li YC, Li CP (2015) Electrochemical simultaneous determination of hydroquinone and p-nitrophenol based on host-guest molecular recognition capability of dual betacyclodextrin functionalized Au@graphene nanohybrids. Sensors Actuators B Chem 207:1–8
9 Preparation of Biosensor Based on Supermolecular Recognization
247