Preparation of Biosensor Based on
Supermolecular Recognization
9
Jingjing Jiang, Xinyi Lin, and Guowang Diao
Contents
9.1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 231
9.2 Biosensing Applications Based on Supermolecular Recognization . . . . . . . . . . . . . . . . . . . . . 232
9.2.1 Metal Ion Detection . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 232
9.2.2 Nucleic Acid Analysis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 234
9.2.3 Immunoassay . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 236
9.2.4 Protein Biosensing . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 238
9.2.5 Small Molecule Determination . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 243
9.3 Conclusion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 247
References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 247
9.1
Introduction
Supermolecular chemistry, also known as “chemistry beyond the molecule,” is an
emerging interdisciplinary research, which focuses on the study of complex and
ordered assemblies formed by noncovalent interactions, such as metal coordination,
hydrogen bonding, π-π stacking, van der Waals force, and hydrophobic interaction
[1, 2]. As an important research content in supermolecular chemistry, host-guest
molecular recognization refers to the process in which a receptor molecule (host)
specifically binds with a ligand molecule (guest) through noncovalent interactions and
subsequently produces a certain function. The electronic properties and geometry
structures of host molecules play an extremely significant role in host-guest
recognization. The former enables the interactions between various molecules to
obtain effective utilization, and the latter helps to match their geometric configurations
with molecular sizes. The unique properties of supermolecular recognization hold
J. Jiang · X. Lin · G. Diao (*)
School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, Jiangsu, China
e-mail: gwdiao@yzu.edu.cn
© Springer Nature Singapore Pte Ltd. 2020
Y. Liu et al. (eds.), Handbook of Macrocyclic Supramolecular Assembly,
https://doi.org/10.1007/978-981-15-2686-2_10
231
Supermolecular Recognization
9
Jingjing Jiang, Xinyi Lin, and Guowang Diao
Contents
9.1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 231
9.2 Biosensing Applications Based on Supermolecular Recognization . . . . . . . . . . . . . . . . . . . . . 232
9.2.1 Metal Ion Detection . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 232
9.2.2 Nucleic Acid Analysis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 234
9.2.3 Immunoassay . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 236
9.2.4 Protein Biosensing . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 238
9.2.5 Small Molecule Determination . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 243
9.3 Conclusion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 247
References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 247
9.1
Introduction
Supermolecular chemistry, also known as “chemistry beyond the molecule,” is an
emerging interdisciplinary research, which focuses on the study of complex and
ordered assemblies formed by noncovalent interactions, such as metal coordination,
hydrogen bonding, π-π stacking, van der Waals force, and hydrophobic interaction
[1, 2]. As an important research content in supermolecular chemistry, host-guest
molecular recognization refers to the process in which a receptor molecule (host)
specifically binds with a ligand molecule (guest) through noncovalent interactions and
subsequently produces a certain function. The electronic properties and geometry
structures of host molecules play an extremely significant role in host-guest
recognization. The former enables the interactions between various molecules to
obtain effective utilization, and the latter helps to match their geometric configurations
with molecular sizes. The unique properties of supermolecular recognization hold
J. Jiang · X. Lin · G. Diao (*)
School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, Jiangsu, China
e-mail: gwdiao@yzu.edu.cn
© Springer Nature Singapore Pte Ltd. 2020
Y. Liu et al. (eds.), Handbook of Macrocyclic Supramolecular Assembly,
https://doi.org/10.1007/978-981-15-2686-2_10
231