70
This work has been co-financed by the European Union and
Greek national funds through the program “Support for
Researchers with Emphasis on Young Researchers” (call code:
EDBM34, ΚΕ 14995) and under the research title “Preparation
and study of innovative forms of administration of pharmaceutical
molecules targeting at improved pharmacological properties.”
References
1. Gleiter CH, Mörike KE (2002) Clinical
pharmacokinetics
of
candesartan.
Clin
Pharmacokinet 41(1):7–17
2. Gidwani B, Vyas A (2015) A comprehensive
review on cyclodextrin-based carriers for delivery of chemotherapeutic cytotoxic anticancer
drugs. Biomed Res Int 2015:15
3. Al Omari A, Al Omari M, Badwan AA et al
(2011) Effect of cyclodextrins on the solubility and stability of candesartan cilexetil in
solution and solid state. J Pharm Biomed Anal
54:503–509
4. Ntountaniotis D, Kellici TF, Gkeka P et al.
(2019) Drug-membrane interactions in the
renin angiotensin system: applications and
practical considerations. p. 339–364
5. Gould S, Scott RC (2005) 2-Hydroxypropyl-βcyclodextrin (HP-β-CD): a toxicology review.
Food Chem Toxicol 43(10):1451–1459
6. Hanumegowda UM, Wu Y, Adams SP (2014)
Potential impact of cyclodextrin-containing
formulations in toxicity evaluation of novel
compounds in early drug discovery. Conference
Proceedings
7. Hub JS, de Groot BL, van der Spoel D (2010)
g_wham—a free weighted histogram analysis
implementation including robust error and
autocorrelation estimates. J Chem Theory
Comput 6(12):3713–3720
8. Berendsen HJC, van der Spoel D, van Drunen
R (1995) GROMACS: a message-passing
parallel molecular dynamics implementation.
Comput Phys Commun 91(1):43–56
9. 20192, SR Maestro (2019) Schrödinger. LLC,
New York, NY
10. Pettersen EF, Goddard TD, Huang CC et al
(2004) UCSF Chimera—A visualization system for exploratory research and analysis. J
Comput Chem 25:1605–1612
11. Zoete V, Cuendet MA, Grosdidier A et al
(2011) SwissParam: a fast force field generation
tool for small organic molecules. J Comput
Chem 32(11):2359–2368
12. Halgren TA (1996) Merck molecular force
field. I. Basis, form, scope, parameterization,
and performance of MMFF94. J Comput
Chem 17(5–6):490–519
13. Best RB, Zhu X, Shim J et al (2012)
Optimization of the additive CHARMM allatom protein force field targeting improved
sampling of the backbone φ, ψ and side-chain
χ(1) and χ(2) dihedral angles. J Chem Theory
Comput 8(9):3257–3273
14. Humphrey W, Dalke A, Schulten K (1996)
VMD - visual molecular dynamics. J Mol
Graph 14:33–38
Sofia Kiriakidi and Thomas Mavromoustakos
This work has been co-financed by the European Union and
Greek national funds through the program “Support for
Researchers with Emphasis on Young Researchers” (call code:
EDBM34, ΚΕ 14995) and under the research title “Preparation
and study of innovative forms of administration of pharmaceutical
molecules targeting at improved pharmacological properties.”
References
1. Gleiter CH, Mörike KE (2002) Clinical
pharmacokinetics
of
candesartan.
Clin
Pharmacokinet 41(1):7–17
2. Gidwani B, Vyas A (2015) A comprehensive
review on cyclodextrin-based carriers for delivery of chemotherapeutic cytotoxic anticancer
drugs. Biomed Res Int 2015:15
3. Al Omari A, Al Omari M, Badwan AA et al
(2011) Effect of cyclodextrins on the solubility and stability of candesartan cilexetil in
solution and solid state. J Pharm Biomed Anal
54:503–509
4. Ntountaniotis D, Kellici TF, Gkeka P et al.
(2019) Drug-membrane interactions in the
renin angiotensin system: applications and
practical considerations. p. 339–364
5. Gould S, Scott RC (2005) 2-Hydroxypropyl-βcyclodextrin (HP-β-CD): a toxicology review.
Food Chem Toxicol 43(10):1451–1459
6. Hanumegowda UM, Wu Y, Adams SP (2014)
Potential impact of cyclodextrin-containing
formulations in toxicity evaluation of novel
compounds in early drug discovery. Conference
Proceedings
7. Hub JS, de Groot BL, van der Spoel D (2010)
g_wham—a free weighted histogram analysis
implementation including robust error and
autocorrelation estimates. J Chem Theory
Comput 6(12):3713–3720
8. Berendsen HJC, van der Spoel D, van Drunen
R (1995) GROMACS: a message-passing
parallel molecular dynamics implementation.
Comput Phys Commun 91(1):43–56
9. 20192, SR Maestro (2019) Schrödinger. LLC,
New York, NY
10. Pettersen EF, Goddard TD, Huang CC et al
(2004) UCSF Chimera—A visualization system for exploratory research and analysis. J
Comput Chem 25:1605–1612
11. Zoete V, Cuendet MA, Grosdidier A et al
(2011) SwissParam: a fast force field generation
tool for small organic molecules. J Comput
Chem 32(11):2359–2368
12. Halgren TA (1996) Merck molecular force
field. I. Basis, form, scope, parameterization,
and performance of MMFF94. J Comput
Chem 17(5–6):490–519
13. Best RB, Zhu X, Shim J et al (2012)
Optimization of the additive CHARMM allatom protein force field targeting improved
sampling of the backbone φ, ψ and side-chain
χ(1) and χ(2) dihedral angles. J Chem Theory
Comput 8(9):3257–3273
14. Humphrey W, Dalke A, Schulten K (1996)
VMD - visual molecular dynamics. J Mol
Graph 14:33–38
Sofia Kiriakidi and Thomas Mavromoustakos