43
Acknowledgments
This work has been co-financed by the European Union and Greek
national funds through the program “Support for Researchers
with Emphasis on Young Researchers” (call code: EDBM34, ΚΕ
14995) and under the research title “Preparation and study of
innovative forms of administration of pharmaceutical molecules
targeting at improved pharmacological properties.”
References
1. Loftsson T, Saokham P, Sá Couto AR (2019)
Self-association of cyclodextrins and cyclodextrin complexes in aqueous solutions. Int J
Pharm 560:228–234
2. He X (2009) Chapter 18. Integration of physical, chemical, mechanical, and biopharmaceutical properties in solid oral dosage form
development. In: Qiu Y et al (eds) Developing
solid oral dosage forms. Academic Press, San
Diego, CA
3. Jansook P, Kurkov SV, Loftsson T (2010)
Cyclodextrins
as
solubilizers:
formation of complex aggregates. J Pharm Sci
99(2):719–729
4. Messner M, Kurkov SV, Brewster ME
et al (2011) Self-assembly of cyclodextrin complexes: aggregation of hydrocortisone/cyclodextrin complexes. Int J Pharm
407(1–2):174–183
5. Messner M, Kurkov SV, Palazón MM et al
(2011) Self-assembly of cyclodextrin complexes: effect of temperature, agitation and
media composition on aggregation. Int J
Pharm 419(1):322–328
6. Sá Couto AR, Ryzhakov A, Loftsson T (2018)
2-Hydroxypropyl-β-cyclodextrin aggregates:
identification and development of analytical techniques. Materials (Basel, Switzerland)
11(10):1971
7. Saokham P, Loftsson T (2015) A new
approach for quantitative determination of
γ-cyclodextrin in aqueous solutions: application in aggregate determinations and solubility in hydrocortisone/γ-cyclodextrin inclusion
complex. J Pharm Sci 104(11):3925–3933
8. Sá Couto AR, Ryzhakov A, Loftsson T
(2018) Self-assembly of α-cyclodextrin and
β-cyclodextrin: identification and development of analytical techniques. J Pharm Sci
107(8):2208–2215
9. Saokham P, Sá Couto A, Ryzhakov A et al
(2016) The self-assemble of natural cyclodextrins in aqueous solutions: application of
miniature permeation studies for critical aggregation concentration (cac) determinations. Int
J Pharm 505(1–2):187–193
10. Stappaerts J, Do Thi T, Dominguez-Vega E
et al (2017) The impact of guest compounds
on cyclodextrin aggregation behavior: a series
of structurally related parabens. Int J Pharm
529(1):442–450
11. Saokham P, Do TT, Van den Mooter
G et al (2018) Inclusion complexes
of p- hydroxybenzoic acid esters and
γ-cyclodextrin. J Incl Phenom Macrocycl
Chem 90(1):111–122
12. Jansook P, Loftsson T (2009) CDs as solubilizers: effects of excipients and competing drugs.
Int J Pharm 379(1):32–40
13. Jansook P, Ritthidej GC, Ueda H et al (2010)
γCD/HPγCD mixtures as solubilizer: solidstate characterization and sample dexamethasone eye drop suspension. J Pharm Pharm Sci
13(3):336–350
14. Muankaew C, Jansook P, Loftsson T (2017)
Evaluation of γ-cyclodextrin effect on permeation of lipophilic drugs: application of cellophane/fused octanol membrane. Pharm Dev
Technol 22(4):562–570
Aggregate Determination by Permeation Technique
Acknowledgments
This work has been co-financed by the European Union and Greek
national funds through the program “Support for Researchers
with Emphasis on Young Researchers” (call code: EDBM34, ΚΕ
14995) and under the research title “Preparation and study of
innovative forms of administration of pharmaceutical molecules
targeting at improved pharmacological properties.”
References
1. Loftsson T, Saokham P, Sá Couto AR (2019)
Self-association of cyclodextrins and cyclodextrin complexes in aqueous solutions. Int J
Pharm 560:228–234
2. He X (2009) Chapter 18. Integration of physical, chemical, mechanical, and biopharmaceutical properties in solid oral dosage form
development. In: Qiu Y et al (eds) Developing
solid oral dosage forms. Academic Press, San
Diego, CA
3. Jansook P, Kurkov SV, Loftsson T (2010)
Cyclodextrins
as
solubilizers:
formation of complex aggregates. J Pharm Sci
99(2):719–729
4. Messner M, Kurkov SV, Brewster ME
et al (2011) Self-assembly of cyclodextrin complexes: aggregation of hydrocortisone/cyclodextrin complexes. Int J Pharm
407(1–2):174–183
5. Messner M, Kurkov SV, Palazón MM et al
(2011) Self-assembly of cyclodextrin complexes: effect of temperature, agitation and
media composition on aggregation. Int J
Pharm 419(1):322–328
6. Sá Couto AR, Ryzhakov A, Loftsson T (2018)
2-Hydroxypropyl-β-cyclodextrin aggregates:
identification and development of analytical techniques. Materials (Basel, Switzerland)
11(10):1971
7. Saokham P, Loftsson T (2015) A new
approach for quantitative determination of
γ-cyclodextrin in aqueous solutions: application in aggregate determinations and solubility in hydrocortisone/γ-cyclodextrin inclusion
complex. J Pharm Sci 104(11):3925–3933
8. Sá Couto AR, Ryzhakov A, Loftsson T
(2018) Self-assembly of α-cyclodextrin and
β-cyclodextrin: identification and development of analytical techniques. J Pharm Sci
107(8):2208–2215
9. Saokham P, Sá Couto A, Ryzhakov A et al
(2016) The self-assemble of natural cyclodextrins in aqueous solutions: application of
miniature permeation studies for critical aggregation concentration (cac) determinations. Int
J Pharm 505(1–2):187–193
10. Stappaerts J, Do Thi T, Dominguez-Vega E
et al (2017) The impact of guest compounds
on cyclodextrin aggregation behavior: a series
of structurally related parabens. Int J Pharm
529(1):442–450
11. Saokham P, Do TT, Van den Mooter
G et al (2018) Inclusion complexes
of p- hydroxybenzoic acid esters and
γ-cyclodextrin. J Incl Phenom Macrocycl
Chem 90(1):111–122
12. Jansook P, Loftsson T (2009) CDs as solubilizers: effects of excipients and competing drugs.
Int J Pharm 379(1):32–40
13. Jansook P, Ritthidej GC, Ueda H et al (2010)
γCD/HPγCD mixtures as solubilizer: solidstate characterization and sample dexamethasone eye drop suspension. J Pharm Pharm Sci
13(3):336–350
14. Muankaew C, Jansook P, Loftsson T (2017)
Evaluation of γ-cyclodextrin effect on permeation of lipophilic drugs: application of cellophane/fused octanol membrane. Pharm Dev
Technol 22(4):562–570
Aggregate Determination by Permeation Technique