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SupramoleculeS in Drug DiScovery anD Drug Delivery: methoDS anD protocolS
Index
Poly(N-isopropylacrylamide)-b-poly(lauryl acrylate)
(PNIPAM-b-PLA) ��223–230
Polyacrylates (PA) ��203
Polyalacticle (PL) ��203
Polydispersities ��79, 80, 136, 148, 204, 227–230
Polyethylene glycol (PEG) �� 28, 30, 199–217, 259, 261
Polymer therapeutics ��71
Polymeric micelles �� 76–79, 86
Polymeric nanocarriers �� 80, 86
Polymerizations ��73, 87, 129, 130, 132, 135,
140, 142, 143, 153, 229
Polymers �� 42, 73–75, 77, 81, 85, 86, 88,
127, 129, 137, 139, 141, 143–145, 147–149, 152,
163, 203–206, 221, 222, 225–227, 229–232, 247,
251, 252, 258, 260, 264, 267, 269–272, 277–279,
299, 300, 305, 307, 308
Polymersomes ��139–149
Polypeptides �� 132–133, 135–137
Polyphenols �� 5, 265, 266
Poorly water-soluble molecules ��248
Precipitation ��37, 76, 80, 81, 130, 132, 258
Pretransition ��226, 303, 304, 308
Proliferation �� 91–93, 184, 200, 202, 255
p-sulfonatocalix[4]arene �� 176, 177, 179, 237,
241, 242, 244
PTFE membrane filters �� 17, 19–21
Q
Quantum mechanics ��110
Quercetin (QUE) ��4, 5, 8, 235, 236, 241–244,
264, 265, 287–289, 293–296
R
Recrystallizations �� 131, 143, 249
Redox �� 86, 88, 137, 285–288, 292, 294, 295
Release �� 14–15, 22, 30, 38, 46, 48, 71,
86–90, 96, 99–101, 110, 136, 139, 148–149, 152,
155, 190, 203, 205, 206, 209–213, 222, 249–260,
264–266, 268–274, 276, 278, 279, 303, 308, 316,
317, 329
Ring opening polymerization �� 73, 143
Rosin esters��199–217
Rosmarinic acid (RA) �� 4, 7
S
Sartans �� 110, 164–171
Scanning electron microscopy
(SEM) �� 129, 156–158, 160, 249
Scratch �� 93, 94, 163
Secondary structure �� 128, 136
Self-assembly properties ��71
Self-healing hydrogel ��136
Silibinin (SLB) �� 4, 7, 9
Size distributions �� 79–81, 204, 207, 227, 229
Size exclusion chromatography (SEC) �� 129, 141, 148
Sleep disorders ��270
Slurry complexation ��3
Sodium dodecyl sulfate
(SDS) ��29, 99, 101, 102, 105, 316–322
Solid state NMR and solution state NMR �� 258, 305, 318
Solubility �� 4, 5, 9, 13, 42, 45, 72, 99, 100, 109,
110, 165, 175–185, 187, 188, 190, 191, 200,
202–205, 207, 235, 236, 238, 248, 249, 251,
254–256, 258, 259, 261–266, 268, 269, 271, 272,
276, 278, 279, 287, 316, 327, 330, 337
Solvent evaporation ��77, 206, 207, 268
Solvents ��4, 17, 21, 152
Sonication �� 20, 33, 88, 105, 155, 160, 210,
216, 227, 231, 259, 301, 318
Spectroscopic �� 22, 188
Sphingolipids (SPL) ��200–202
Spin labels ��101, 102, 106, 107
Stabilizers ��277
Steered MD ��45–69
Steroids ��273–276
Stimuli responsive �� 221, 252
Stoichiometry ��191, 195, 196, 314
Structural properties ��318
Supramolecular carriers ��238
Supramolecular chemistry ��176
Synthesis of polypeptides ��134
T
Targeted Drug Delivery��86
Temozolomide (TMZ) �� 176, 177, 179–185, 236,
237, 241, 242, 244, 250, 251
Temperatures �� 4, 5, 16–20, 31, 32, 36, 37, 39,
42, 55, 57, 73–75, 86–90, 96, 102, 107, 117, 118,
129, 132, 133, 135–137, 139, 141, 146, 148, 152,
154, 163, 164, 167, 169, 170, 179, 183, 185, 188,
189, 192, 195, 196, 206, 207, 210, 217, 222, 227,
229–232, 241, 245, 252, 253, 259, 267, 271, 274,
277, 289–291, 302–305, 319, 320, 333–336
ε-tert-butoxycarbonyl-l-lysine ��130, 132, 135, 142
Theranostics �� 85–87, 221
Therapies ��100, 151, 205, 221, 254, 255,
262, 268, 269
Thermal analysis (TA) �� 9, 163, 164
Thermo ��28, 29, 32, 86
Thermodynamic parameters �� 168, 171, 188, 194,
195, 225, 302, 303
Thermodynamics ��2, 46, 165, 168, 170, 187–196,
221–232
Thermograms ��164, 165, 167–169, 225, 302,
303, 309, 310
Thermoresponsive �� 221–232, 306
Thermotropic behavior �� 225, 299–310
Thin film hydration ��72, 73, 81, 224, 227, 300, 303

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