338
9. Vrettos EI, Sayyad N, Mavrogiannaki
EM, Stylos E, Kostagianni AD, Papas S,
Mavromoustakos T, Theodorou V, Tzakos
AG (2017) Unveiling and tackling guanidinium peptide coupling reagent side reactions
towards the development of peptide-drug conjugates. RSC Adv 7:50519–50526
10. Gründker C, Emons G (2017) The role of
gonadotropin-releasing hormone in cancer cell
proliferation and metastasis. Front Endocrinol
(Lausanne) 8:187–187
11. de Sousa Cavalcante L, Monteiro G (2014)
Gemcitabine: metabolism and molecular
mechanisms of action, sensitivity and chemoresistance in pancreatic cancer. Eur J Pharmacol
741:8–16
12. Sayyad N, Vrettos EI, Karampelas T,
Chatzigiannis CM, Spyridaki K, Liapakis
G, Tamvakopoulos C, Tzakos AG (2019)
Development of bioactive gemcitabineD- Lys(6)-GnRH prodrugs with linkercontrollable drug release rate and enhanced
biopharmaceutical profile. Eur J Med Chem
166:256–266
13. Karampelas T, Argyros O, Sayyad N,
Spyridaki K, Pappas C, Morgan K, Kolios
G, Millar RP, Liapakis G, Tzakos AG,
Fokas D, Tamvakopoulos C (2014) GnRHGemcitabine conjugates for the treatment
of androgen- independent prostate cancer:
pharmacokinetic enhancements combined
with targeted drug delivery. Bioconjug Chem
25:813–823
14. Spears RJ, Fascione MA (2016) Site-selective
incorporation and ligation of protein aldehydes. Org Biomol Chem 14(32):7622–7638
Eirinaios I. Vrettos and Andreas G. Tzakos
9. Vrettos EI, Sayyad N, Mavrogiannaki
EM, Stylos E, Kostagianni AD, Papas S,
Mavromoustakos T, Theodorou V, Tzakos
AG (2017) Unveiling and tackling guanidinium peptide coupling reagent side reactions
towards the development of peptide-drug conjugates. RSC Adv 7:50519–50526
10. Gründker C, Emons G (2017) The role of
gonadotropin-releasing hormone in cancer cell
proliferation and metastasis. Front Endocrinol
(Lausanne) 8:187–187
11. de Sousa Cavalcante L, Monteiro G (2014)
Gemcitabine: metabolism and molecular
mechanisms of action, sensitivity and chemoresistance in pancreatic cancer. Eur J Pharmacol
741:8–16
12. Sayyad N, Vrettos EI, Karampelas T,
Chatzigiannis CM, Spyridaki K, Liapakis
G, Tamvakopoulos C, Tzakos AG (2019)
Development of bioactive gemcitabineD- Lys(6)-GnRH prodrugs with linkercontrollable drug release rate and enhanced
biopharmaceutical profile. Eur J Med Chem
166:256–266
13. Karampelas T, Argyros O, Sayyad N,
Spyridaki K, Pappas C, Morgan K, Kolios
G, Millar RP, Liapakis G, Tzakos AG,
Fokas D, Tamvakopoulos C (2014) GnRHGemcitabine conjugates for the treatment
of androgen- independent prostate cancer:
pharmacokinetic enhancements combined
with targeted drug delivery. Bioconjug Chem
25:813–823
14. Spears RJ, Fascione MA (2016) Site-selective
incorporation and ligation of protein aldehydes. Org Biomol Chem 14(32):7622–7638
Eirinaios I. Vrettos and Andreas G. Tzakos